A5031533063- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Phytoestrogen effects and research
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Endoplasmic Reticulum Stress and Disease
- Sexual Differentiation and Disorders
- Lipid metabolism and disorders
- Sperm and Testicular Function
- Urologic and reproductive health conditions
Universidade de São Paulo
2022-2025
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with cardiometabolic risk. Although studies have shown that estradiol positively contributes to energy metabolism via estrogen receptor alpha (ERα), its role specifically in the not defined. Therefore, this study aimed evaluate effects of ERα overexpression, mice fed a high-fat diet (HFD). Methods: Male C57BL/6J were divided into four groups, vehicle regular chow (RC) (RC-Vehicle); an HFD...
Menopause is characterized by a reduction in sex hormones women and associated with metabolic changes, including fatty liver insulin resistance. Lifestyle balanced diet physical exercise, are necessary to prevent these undesirable changes. Strength training (ST) has been widely used because of the muscle benefits it provides. Our study aims evaluate effects ST on hepatic steatosis resistance ovariectomized mice fed high-fat (HFD) divided into four groups as follows: simulated sedentary...
The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe form, steatohepatitis (NASH), is higher in men than women reproductive age, postmenopausal are especially susceptible to developing the disease. Aim: we evaluated if female apolipoprotein E (ApoE) KO mice were protected against Western-diet (WD)-induced NASH. Methods: Female ovariectomized (OVX) ApoE or sham-operated (SHAM) fed either a WD regular chow (RC) for 7 weeks. Additionally, OVX treated with estradiol (OVX +...
Male patients suffering from oligoasthenoteratozoospermia typically failed to achieve pregnancy, even with assisted reproductive technologies. Growth hormone and insulin-like growth factor 1 have been shown regulate sperm quality parameters; therefore, the supplement could improve parameters. Here, we determine effect has on parameters in a patient oligoasthenoteratozoospermia. A 47-year-old male was administered once day 1.5 IU of by intradermal injection for 2 months. Seminogram analysis...
Lifestyle and increased consumption of high fat diets contribute greatly to the development obesity, insulin resistance, type 2 diabetes (DM2), cardiovascular diseases, which are less prevalent in young women than men same age or postmenopausal women. One consequences Western lifestyle diet is Nonalcoholic Fatty Liver Disease (NAFLD) its aggressive form, Steatohepatitis (NASH), can progress cirrhosis hepatocellular cancer (HCC) rapidly becoming leading cause for end-stage liver disease...