A5054771007- Diabetes, Cardiovascular Risks, and Lipoproteins
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Diet and metabolism studies
- Prenatal Screening and Diagnostics
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Thyroid Cancer Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Health and Lifestyle Studies
- Nutritional Studies and Diet
- Paraoxonase enzyme and polymorphisms
- Folate and B Vitamins Research
- Cancer-related Molecular Pathways
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Cardiovascular Disease and Adiposity
- Assisted Reproductive Technology and Twin Pregnancy
- Dietary Effects on Health
- Gut microbiota and health
Benemérita Universidad Autónoma de Puebla
2019-2024
Mexican Social Security Institute
2014-2023
Instituto Politécnico Nacional
2017-2023
Regenerative Medicine Institute
2022
Center for Research and Advanced Studies of the National Polytechnic Institute
2017-2021
The Ohio State University
2006-2009
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2006-2009
The Ohio State University Wexner Medical Center
2008
American Association of Colleges of Pharmacy
2007
p21-Activated kinases (PAKs) are regulators of cell motility and proliferation. PAK activity is regulated in part by phosphoinositide-dependent kinase 1 (PDK1). We hypothesized that reduced was involved the effects 2-amino-<i>N</i>-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a previously characterized PDK1 inhibitor derived from celecoxib. In three human thyroid cancer lines, OSU-03012 inhibited proliferation with AKT phosphorylation...
Background The aim was to evaluate the effect different types of abdominal fat have on NAFLD development and effects has association between Metabolic Syndrome (MetS) NALFD. Methods Data collected from cross-sectional NHANES dataset (2017–2018 cycle). Using controlled attenuation parameter (USG CAP, dB/m), which measures level steatosis, cohort stratified into two groups: NAFLD(+) (≥274 dB/m) NAFLD(-). complex samples analyses, associations liver steatosis or area [Total (TAFA), subcutaneous...
Background Visceral obesity (VATob) increases the risk for many diseases. Central has been associated with an augmented prescription use; however, there is a paucity of research focused on VATob. Here, aim was to evaluate association between VATob and use. Methods Data collected from NHANES dataset (2011–2018). adipose tissue measured using dual x-ray absorptiometry, defined as ≥100 cm 2 . Prescription use RXQ_RX files classified according Vademecum. Association determined logistic...
Metabolic Syndrome (MetS) is associated with elevated risk for developing diabetes and cardiovascular disease. A key component of MetS the development insulin resistance (IR). The homeostatic model assessment (HOMA) can determine IR by using or C-peptide concentrations; however, efficiency to has not been compared. aim study was compare in Mexicans.Anthropometrics, glucose, insulin, C-peptide, triglycerides, high-density lipoproteins were determined 156 nonpregnant females 114 males....
Objective: This review aims to summarize the association between insulin resistance (IR) and symptoms of Polycystic Ovary Syndrome (PCOS) while explaining how nutritional interventions, specifically ketogenic diets, help manage PCOS. Mechanism: The effect IR on diagnostic criteria for PCOS is first described, followed by a standard diet exacerbates IR. Afterward, women with PCOS, are described. Findings in Brief: associated ovulatory dysfunction, hyperandrogenism, polycystic ovarian...
Metabolic syndrome (MetS) is considered a public health problem worldwide. Recently, oxidative stress (OS) has been proposed as factor related with the genesis of MetS. Different studies have reported decreased antioxidant defense, such superoxide dismutase (SOD), glutathione peroxidase (GPx), reductase (GRed) activities, and reduced (GSH) concentration, and, on other hand, an increase in nitrotyrosine concentration MetS patients. However, it not known whether there direct association...
Metastatic tumors are the primary cause of death in patients with breast cancer. Recent data indicate that peroxisome proliferator-activated receptor gamma (PPARgamma) ligands, thiazolidinediones (TZDs), possess anti-invasive activities on human cancer cells. However, effects TZDs other metastatic properties cells such as adhesion, spreading, and migration not well established. In this study, we show troglitazone (TG), a member TZD family, inhibits lamellipodia formation or membrane ruffling...
Current methods for determining superior embryo quality (morphological assessment) are unable to compensate poor pregnancy outcomes. Due the importance of cumulus-oocyte complex and value cumulus cells (CCs) as markers health, we determined association between CCs gene expression Prostaglandin-Endoperoxide Synthase 2 (PTGS2) Versican (VCAN) with pregnancy.One hundred forty-nine women, suffering from infertility undergoing IVF, were included in this study (age: 29-46 years; BMI = 25.5 ± 5.0...
Male patients suffering from oligoasthenoteratozoospermia typically failed to achieve pregnancy, even with assisted reproductive technologies. Growth hormone and insulin-like growth factor 1 have been shown regulate sperm quality parameters; therefore, the supplement could improve parameters. Here, we determine effect has on parameters in a patient oligoasthenoteratozoospermia. A 47-year-old male was administered once day 1.5 IU of by intradermal injection for 2 months. Seminogram analysis...
Background: Many BRCA1 and BRCA2 mutations have been characterized in breast cancer subjects; however, the overall prevalence Latin American remains elusive. The aim of study was to determine common subjects. Methods: Pubmed, EBSCO, OVID databases, bibliographies were systematically searched for observational studies that examined until March 2015. pooled obtained using inverse double arcsine square root method. Publication bias assessed by Begg Mazumdar’s test Egger’s test. sensitivity...
Introduction. The COVID-19 pandemic caused the cessation of academic activities from face-to-face format to confinement and virtual classes, in which little is studied about its effect on mental health. Objective. Determine levels depression, anxiety, stress medical students Mexico Colombia during pandemic. Furthermore, were compared by gender, education status, country. Method. A cross-sectional study was carried out with 426 students. Data collected using an online survey containing...
Background: Type 2 diabetes mellitus (T2DM) is characterized as a disease continuum that marked by metabolic changes are present for several years, sometimes well before frank diagnosis of T2DM. Genetic predisposition, ethnicity, geography, alterations in BMI, and lipid profile considered important markers the pathogenesis T2DM through mechanisms remain unresolved controversial. The aim this study was to investigate relationship between triglycerides (TGs) β-cell function, insulin resistance...