A5062265079- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Lymphoma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Genital Health and Disease
- Urologic and reproductive health conditions
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Endometrial and Cervical Cancer Treatments
- Soft tissue tumor case studies
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Lung Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Breast Implant and Reconstruction
- TGF-β signaling in diseases
- Urinary and Genital Oncology Studies
- AI in cancer detection
Université Libre de Bruxelles
2011-2025
Institut Jules Bordet
2025
Centre Hospitalier Universitaire de Tivoli
2016-2024
Centre Hospitalier Interrégional Edith Cavell
2020-2024
Erasmus Hospital
2011-2023
Centre Hospitalier Universitaire de Liège
2020
Institute of Pathology and Genetics
2013-2015
Australia New Zealand Gynaecological Oncology Group
2012
Mie University Hospital
2007
Abstract Chemo-immunotherapy is the first-line standard of care for patients with PD-L1 positive metastatic triple-negative breast cancer (mTNBC). SYNERGY (NCT03616886) a dose-finding phase I and randomized II, open-label trial evaluating if targeting immunosuppressive adenosine pathway can enhance antitumor activity chemo-immunotherapy. The part included 6 untreated locally-advanced or mTNBC to determine safety recommended II dose anti-CD73 antibody oleclumab in combination anti-PD-L1...
Primary retroperitoneal mucinous carcinomas (PRMCa) are exceedingly rare and poorly understood neoplasms, with <80 cases documented in the medical literature molecular profiling hardly ever performed. Recent theories suggest that PRMCa might develop from mature cystic teratomas or Brenner tumors, mirroring their ovarian counterparts. However, only 2 of primary tumors associated teratoma have been reported to support this idea. In paper, we detail an exceptional case: a 66-yr-old woman...
The efficacy of immune checkpoint inhibitors is limited in patients with high-grade serous ovarian cancer (HGSC). predictive and prognostic value tumor-stroma proportion (TSP) was assessed HGSC treated platinum-based chemotherapy pembrolizumab the NeoPembrOV trial. TSP quantified as relative stromal tissue to tumor cells (low if <30% or high ≥30%). RNA sequencing multiplex immunofluorescence were conducted. on 85 pre-treatment samples. Patients a low had prolonged progression-free survival...
In breast carcinoma, the stromal loss of CD34 expression and acquisition SMA myofibroblastic features may constitute a prerequisite for tumor invasiveness. However, this hypothesis remains controversial, with some authors describing fibrocytes in absence myofibroblastic-like cells stroma invasive carcinoma. Others have also described disappearance from situ To clarify issue, we compared distribution reactive myofibroblasts between areas tumor-free mammary tissue, ductal carcinoma (DCIS)...
The microenvironment modulates tissue specificity in the normal breast and cancer. stromal loss of CD34 expression acquisition SMA myofibroblastic features may constitute a prerequisite for tumor invasiveness carcinoma. aim present study is to examine cases invasive ductal carcinoma try demonstrate role played by TGF-ß 1 et R1 pathway transformation fibrocytes into myofibroblasts. We carried out an immunohistochemical CD34, SMA, on series 155 patients with also treated cell line TGF-ß1....
Summary Recently, considerable attention has been focused on the identification of clinically relevant prognostic markers for primary central nervous system lymphomas (PCNSL). The present study investigated whether three morphological features, i.e. necrosis, reactive perivascular T‐cell infiltrate and endothelial hyperplasia, galectin‐1 galectin‐3 immunohistochemical expression have roles in a series 58 PCNSL samples from 44 immunocompetent 14 immunocompromised patients. presence...
Objectives . In Belgium, very few studies have focused on cervical high-risk human papillomaviruses (hrHPV) prevalence and the relationship between HPV cytological abnormalities. The aim of this study was to investigate hrHPV its with screening histological results in French-speaking community Belgium (Brussels Wallonia). Methods A total 58,265 liquid-based cytology tests were performed during period. All cases ASC-US, ASC-H, LSIL, HSIL tested by Hybrid Capture 2 for screening. Results...
Cancer progression results from a complex interplay between tumor cells and the extracellular milieu. In breast carcinoma, stromal microenvironment has been suggested to play major role in promoting growth, progression, invasion. The stroma of 154 resected specimens invasive carcinoma no special type was quantified using digital image analyzer. Statistical analyses were performed quantity survival, as well progression-free survival clinicopathological data. Levels myofibroblastic varied...
Female genital schistosomiasis (FGS) is an isolated chronic form of schistosomiasis. Although most infections occur in residents endemic areas, it has been clearly documented that brief freshwater exposure sufficient to establish infection; thus, travellers may also be infected. The clinical manifestations FGS are nonspecific, and lesions mimic any neoplastic or infectious process the female tract. It important take a careful history physical examination, making sure consider travel areas....
The peritumoral stroma and cancer-associated fibroblasts (CAFs) have been suggested to play an important role in breast tumorigenesis. specific immunohistochemical characteristics of the stromal component according carcinoma subtype surrogates molecular classes is poorly understood. In present study, staining was used evaluate expression matrix metalloproteinase 2 (MMP2), which one most proteins considered facilitate tumor invasion, a series invasive carcinomas subtype: luminal A, B,...
Cancer- associated fibroblasts (CAFs) are actively involved in breast carcinoma. Our previous study demonstrated that the majority of these CAFs were smooth muscle actin (SMA) positive and therefore termed peritumoral myofibroblast (PMY). Glucocorticoid, linked or not with its receptor (GR), has been postulated to serve a major role normal carcinoma; however, their remains poorly understood. The aim present was assess presence GR particularly PMY 56 cases invasive carcinoma correlation...
Background: The challenge of breast-conserving surgery (BCS) is to remove the entire tumour with free margins and avoid secondary excision that may adversely affect cosmetic outcome. Consequently, intraoperative evaluation surgical critical. aims this study were multiple. First, analyse our methodology examination resection evaluate radiological pathological methods in assessment margins. Second, factors associated positive patient population. M&m: data on margin status 290 patients who...
The modification of stromal components with the disappearance CD34 positive fibrocytes and by contrast acquisition smooth-muscle actin myofibroblasts is a frequent event in breast carcinomas but has been little studied its metastatic sites. Therefore, aim present study to examine expression SMA lymph node liver metastases which are two most cancer sites.The distribution immunohistochemistry 41 36 from patients invasive carcinoma no special type.No CD 34 were noted stroma metastasis. By...
Background In the era of “precision medicine,” availability high-quality tumor biomarker tests is critical and proliferation evaluated by Ki-67 antibody one most important prognostic factors in breast cancer. But evaluation index has been shown to suffer from some interobserver variability. The goal study develop an easy, automated, reliable assessment approach for invasive carcinoma routine practice. Patients Methods A total 151 biopsies were analyzed. was 2 pathologists with MIB-1 as a...
Lymphoepithelioma-like carcinoma of the endometrium is a very rare variant endometrial characterized by syncytial nests pleomorphic epithelial cells and heavy infiltration stroma lymphocytes (in particular CD8 cytotoxic T-lymphocytes) plasma cells. Until now, only five cases have been in this location. This report describes clinicopathological molecular features unusual tumor. In particular, using next generation sequencing (NGS) technique, we demonstrated that tumor could be associated with...
Adenolipoleiomyoma is a very rare lesion of the uterus. Only four cases were reported. We describe one case adenolipoleiomyoma presenting as polyp in postmenopausal woman with menorrhagia. and histogenesis remains unclear. discuss origin differential diagnosis this lesion.
Primary ovarian intestinal-type mucinous carcinomas associated with mature teratoma are rare and represent less than 3% of all primary neoplasms. The molecular profile these tumors is still controversial. We report here the first case tumor in which mutation PIK3CA P53 genes could be demonstrated by next generation sequencing technique without KRAS or HER2 amplification. Our data suggest that carcinoma variants probably present an extremely complex biology should known future to stratify...
<b><i>Objective:</i></b> To investigate the feasibility of technique cell blocks (CBs) from residual fluids Papanicolaou (Pap) smears diagnosed as low-grade abnormalities in detection high-grade lesions on biopsies. <b><i>Study Design:</i></b> In present pilot study, we evaluated sensitivity and specificity 70 CBs liquid-based cervicovaginal women with atypical squamous cells (ASCs) undetermined significance (ASCUS; n = 39), ASCs that cannot...
Recently, several trials demonstrated the safety of omitting axillary lymph node dissection in clinically N0 patients with positive sentinel nodes select subgroups. However, this fact is still troublesome to clarify surgeons and clinicians, as they used perform intraoperative examination for many years. Hence, we decided review our practice. This firstly highlight predictive factors metastasis secondly, evaluate effectiveness node. There were 406 total procedures. The rate final diagnosis...