A5046392248- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Bone health and treatments
- Cystic Fibrosis Research Advances
- Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Cardiovascular Function and Risk Factors
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related cognitive impairment studies
- Phosphodiesterase function and regulation
- Inhalation and Respiratory Drug Delivery
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac electrophysiology and arrhythmias
- Advanced biosensing and bioanalysis techniques
- Biochemical and Molecular Research
- Membrane Separation Technologies
- Pharmacological Receptor Mechanisms and Effects
- Antimicrobial Peptides and Activities
- Veterinary Pharmacology and Anesthesia
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Ischemia and Reperfusion
University of Palermo
2017-2025
University of Turin
2017-2024
Policlinico Universitario di Catania
2021
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2013-2018
University of Messina
2013
Background/Objectives: The prognostic value of baseline clinical parameters in predicting the survival prolonging effect Radium-223-dichloride (223RaCl2) for metastatic castration resistant prostate cancer (mCRPC) patients has been object intensive research and remains an open issue. This national multicenter study aimed to corroborate evidence ten years experience with 223RaCl2 by collecting data from eight Italian Nuclear Medicine Units. Methods: Data 581 consecutive mCRPC treated were...
Expiratory CT scan is usually obtained as supplement to normal inspiratory recognize air-trapping, which expression of small airways obstruction. In some patients the air-trapping may be only sign an early-stage disease in otherwise lung.The purpose this article illustrate pathologic conditions, namely obliterative bronchiolitis, expiratory can abnormal despite examination, and highlight indications for technique with clinical functional suspect bronchiolar
Cyclic adenosine 3′,5′-monophosphate (cAMP)–elevating agents, such as β 2 -adrenergic receptor (β -AR) agonists and phosphodiesterase (PDE) inhibitors, remain a mainstay in the treatment of obstructive respiratory diseases, conditions characterized by airway constriction, inflammation, mucus hypersecretion. However, their clinical use is limited unwanted side effects because unrestricted cAMP elevation airways distant organs. Here, we identified A-kinase anchoring protein phosphoinositide...
Prostate cancer frequently causes bone metastases and skeletal events that impair quality of life (QoL) survival. The alpha emitter radium-223 is a new drug improves treatment in men with castration-resistant prostate (CRPC) metastases. Our aim was to evaluate the effectiveness radium-223.In this retrospective study we enrolled 48 subjects. Pain reduction, alkaline phosphatase (ALP), time first symptomatic event, QoL were variables evaluated.Radium-223 well tolerated, manageable toxicity...
Cystic fibrosis (CF), the most common genetic disease among Caucasian population, is caused by mutations in gene encoding for CF transmembrane conductance regulator (CFTR), a chloride epithelial channel whose dysfunction results severe airway obstruction and inflammation, eventually leading to respiratory failure. The discovery of CFTR 1989 provided new insights into basic defect allowed study potential therapies targeting aberrant protein. In recent years, approval “CFTR modulators”, first...
Treatment with radium-223 has been shown to increase survival and delay skeletal events related bone metastases of patients metastatic Castration Resistant Prostate Cancer (mCRPC). This treatment also proved be well tolerated, hematological toxicity, in particular anemia, represents the most represented adverse event.We evaluated hematologic toxicity Ra-223 a real-life experience 38 from two Italian cancer centers, mCRPC. The main endpoint study was evaluation efficacy tolerability...
Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic Phase 1 2 trials documented a clinical efficacy also breast cancer predominately disease, highlighting reduction alkaline phosphatase other biomarkers. In our institution, patient affected by osteolytic was treated off-label use Ra223. Our had good treatment compliance up...
Expiratory CT scan is usually obtained as supplement to normal inspiratory recognize air-trapping, which expression of small airways obstruction. In some patients the air-trapping may be only sign an early-stage disease in otherwise lung. The purpose this article illustrate pathologic conditions, namely obliterative bronchiolitis, expiratory can abnormal despite examination, and highlight indications for technique with clinical functional suspect bronchiolar
Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic In our institution, a patient breast cancer affected by osteolytic was treated off-label use Ra223. The evaluation deposit areas Ra223 showed perfect overlap regions osteolysis previously detected scintigraphy, indicating possible therapeutic effect. This case report...
Abstract Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting compromise in body's osseous healing mechanisms unique to craniofacial region. Radium 223 dichloride (Ra223) only targeted alpha therapy able extend survival patients with metastases from prostate cancer. Mechanism action data currently available focused mainly on osteoblastic In 2018, Caucasian 54-year-old woman presented our institution for breast cancer metastases. Since patient refused any...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Doctoral fellowship Introduction Phosphoinositide 3-kinase C2α (PI3KC2α) is a ubiquitously expressed class II PI3K isoform, which has been previously shown to be involved in the control vesicular trafficking. However, its role myocardium not investigated. The primary aim this study elucidate mechanism by PI3KC2α controls cardiac pathophysiology. Methods Cardiomyocyte-specific...