A5023490611- Receptor Mechanisms and Signaling
- Estrogen and related hormone effects
- Signaling Pathways in Disease
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Protein Degradation and Inhibitors
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- RNA Research and Splicing
University of Alabama at Birmingham
2023-2025
Civitan International
2023
Drugs of abuse increase extracellular concentrations dopamine in the nucleus accumbens (NAc), resulting transcriptional alterations that drive long-lasting cellular and behavioral adaptations. While decades research have focused on mechanisms by which drugs influence neuronal physiology function, few studies comprehensively defined NAc cell type heterogeneity responses to abuse. Here, we used single RNA-seq (snRNA-seq) characterize transcriptome over 39,000 cells from male female adult...
Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function guide enduring plasticity. activation promotes expression an immediate early gene (IEG) program comprised primarily activity-dependent transcription factors, thought regulate a second set late response genes (LRGs). However, while the mechanisms governing IEG have been well studied, molecular interplay between IEGs LRGs remain poorly...
Pregnancy and postpartum experiences represent transformative physiological states that impose lasting demands on the maternal body brain, resulting in lifelong neural adaptations. However, precise molecular mechanisms driving these persistent alterations remain poorly understood. Here, we used brain-wide transcriptomic profiling to define landscape of parity-induced plasticity, identifying dorsal hippocampus (dHpc) as a key site transcriptional remodeling. Combining single-cell RNA...
Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function guide enduring plasticity. activation promotes expression an immediate early gene (IEG) program comprised primarily activity-dependent transcription factors, thought regulate a second set late response genes (LRGs). However, while the mechanisms governing IEG have been well studied, molecular interplay between IEGs LRGs remain poorly...
Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function guide enduring plasticity. activation promotes expression an immediate early gene (IEG) program comprised primarily activity-dependent transcription factors, thought regulate a second set late response genes (LRGs). However, while the mechanisms governing IEG have been well studied, molecular interplay between IEGs LRGs remain poorly...
Drugs of abuse increase extracellular concentrations dopamine in the nucleus accumbens (NAc), resulting transcriptional alterations that drive long-lasting cellular and behavioral adaptations. While decades research have focused on mechanisms by which drugs influence neuronal physiology function, few studies comprehensively defined NAc cell type heterogeneity responses to abuse. Here, we used single RNA-seq (snRNA-seq) characterize transcriptome over 39,000 cells from male female adult...
Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function guide enduring plasticity. activation promotes expression an immediate early gene (IEG) program comprised primarily activity-dependent transcription factors, thought regulate a second set late response genes (LRGs). However, while the mechanisms governing IEG have been well studied, molecular interplay between IEGs LRGs remain poorly...
Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function guide enduring plasticity. activation promotes expression an immediate early gene (IEG) program comprised primarily activity-dependent transcription factors, thought regulate a second set late response genes (LRGs). However, while the mechanisms governing IEG have been well studied, molecular interplay between IEGs LRGs remain poorly...