A5017155670- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Sarcoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Memory and Neural Mechanisms
- Hematological disorders and diagnostics
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
Allen Institute for Brain Science
2019-2025
Icahn School of Medicine at Mount Sinai
2019-2025
Medical College of Wisconsin
2018-2025
University of Wisconsin–Madison
2015-2022
UW Health University Hospital
2022
University of Colorado Boulder
2018-2019
New York Psychoanalytic Society and Institute
2018-2019
Columbia University
2018-2019
ProHealth Oconomowoc Memorial Hospital
2019
Community Information, Empowerment and Transparency
2016
Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates represent a substantial public health crisis that exacts tremendous personal financial costs on patients society. Sharp increases in cocaine drive the urgent need for better mechanistic insight into this chronic relapsing brain currently lacks effective treatment options. To investigate transcriptomic changes involved, we conducted RNA sequencing two striatal regions are heavily implicated CUD, nucleus...
Abstract Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles permissive gene expression 1–3 . We previously demonstrated serotonylation 4–10 and dopaminylation 9,11–13 histone (H3Q5ser H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), alter both local global chromatin states. Here we found TG2 additionally functions as eraser exchanger monoaminylations, including H3Q5 histaminylation (H3Q5his), which displays...
Emerging magnetic resonance imaging (MRI) biomarkers of hepatic steatosis have demonstrated tremendous promise for accurate quantification triglyceride concentration. These methods quantify the proton density fat‐fraction (PDFF), which reflects concentration triglycerides in tissue. Previous vivo studies compared MRI‐PDFF with histologic grading assessment steatosis. However, correlation underlying content remained unknown. The aim this ex study was to validate accuracy as an biomarker Using...
Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful rewarding. Perturbations, especially during this have been shown alter behavior in adulthood. Social isolation rearing one such perturbation. This review highlights the long-term consequences of adolescent social rodents specific focus on anxiety- addiction-related behaviors. Sex-specific effects discussed where data available. We...
Opioid use disorder (OUD) looms as one of the most severe medical crises facing society. More effective therapeutics will require a deeper understanding molecular changes supporting drug-taking and relapse. Here, we develop brain reward circuit-wide atlas opioid-induced transcriptional regulation by combining RNA sequencing (RNA-seq) heroin self-administration in male mice modeling multiple OUD-relevant conditions: acute exposure, chronic intake, context-induced drug-seeking following...
Brain development requires appropriate regulation of serotonin (5-HT) signaling from distinct tissue sources across embryogenesis. At the maternal-fetal interface, placenta is thought to be an important contributor offspring brain 5-HT and critical overall fetal health. Yet, how placental acquired, mechanisms through which influences functions, are not well understood. Recently, our group identified a novel epigenetic role for 5-HT, in can added histone proteins regulate transcription,...
Abstract We assessed differences in survival between non-Hispanic black (NHB) and white (NHW) patients with multiple myeloma (MM), the sequential effects of patient characteristics, diagnosis treatment-related factors on disparity using data from 3319 NHB 20,831 NHW MM SEER-Medicare (1999–2017) database. Four sets NHWs were matched sequentially to same set NHBs, based demographics (age, sex, year diagnosis, marital status, SEER site), socioeconomic status (SES, plus SES), presentation (SES...
Pregnancy and postpartum experiences represent transformative physiological states that impose lasting demands on the maternal body brain, resulting in lifelong neural adaptations. However, precise molecular mechanisms driving these persistent alterations remain poorly understood. Here, we used brain-wide transcriptomic profiling to define landscape of parity-induced plasticity, identifying dorsal hippocampus (dHpc) as a key site transcriptional remodeling. Combining single-cell RNA...
PURPOSE Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy characterized by t(11;14) and bright CD20 expression. To improve outcomes from single targeted CD19 chimeric antigen receptor (CAR) T cells, we used dual lentiviral anti-CD20/anti-CD19 (LV20.19) CAR cells as part of a phase I/II clinical trial in relapsed, refractory (R/R) MCL (ClinicalTrials.gov identifier: NCT04186520 ). METHODS Patients with who had failed two lines therapy or relapsed post-transplant were eligible....
Paternal stress can induce long-lasting changes in germ cells potentially propagating heritable across generations. To date, no studies have investigated differences transmission patterns between stress-resilient and stress-susceptible mice. We tested the hypothesis that transcriptional alterations sperm during chronic social defeat (CSDS) transmit increased susceptibility to phenotypes next generation. demonstrate offspring from stressed fathers depend on paternal category (resilient vs...
Opioid use disorder (OUD) looms as one of the most severe medical crises currently facing society. More effective therapeutics for OUD requires in-depth understanding molecular changes supporting drug-taking and relapse. Recent efforts have helped advance these aims, but studies been limited in number scope. Here, we develop a brain reward circuit-wide atlas opioid-induced transcriptional regulation by combining RNA sequencing (RNAseq) heroin self-administration male mice modeling multiple...
The serotonin 1A receptor (5-HT1A) system has been extensively implicated in modulating mood and behavior. Notably, 5-HT1A levels humans display remarkable variation, differences have linked with a variety of psychiatric disorders. Further, reduction by 30–50% mice suggests that changes model existing human variation are sufficient to drive behavioral alterations. As result, genetic mechanisms modulate may be important for explaining individual behavior, representing potential source disease...
ABSTRACT Adolescence is a sensitive window for reward- and stress-associated behavior. Although stress during this period causes long-term changes in behavior males, how females respond relatively unknown. Here we show that social isolation adolescence, but not adulthood, induces persistent opposite effects on anxiety- cocaine-related behaviors male vs. female mice, these are reflected transcriptional profiles within the adult medial amygdala (meA). By integrating differential gene...