A5069790998- Genetics and Neurodevelopmental Disorders
- Glycogen Storage Diseases and Myoclonus
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Microtubule and mitosis dynamics
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Resilience and Mental Health
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Migration, Health and Trauma
- Ion Transport and Channel Regulation
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Neuroscience and Neuropharmacology Research
- Genomics and Rare Diseases
- Identity, Memory, and Therapy
- Hormonal Regulation and Hypertension
- Posttraumatic Stress Disorder Research
Maastricht University
2015-2023
Maastricht University Medical Centre
2017-2023
European Graduate School of Neuroscience
2017-2023
University of California, Los Angeles
2019
University of Liège
2006-2018
Université du Québec à Montréal
2018
Temple University
2018
University of California, San Diego
2018
Tulane University
2018
University of California, San Francisco
2018
In order to determine the impact of epigenetic response traumatic stress on post-traumatic disorder (PTSD), this study examined longitudinal changes genome-wide blood DNA methylation profiles in relation development PTSD symptoms two prospective military cohorts (one discovery and one replication data set). first cohort consisting male Dutch servicemen (n=93), emergence over a deployment period combat zone was significantly associated with alterations levels at 17 genomic positions 12...
In juvenile myoclonic epilepsy, data are limited on the genetic basis of networks promoting convulsions with diffuse polyspikes electroencephalography (EEG) and subtle microscopic brain dysplasia called microdysgenesis.Using Sanger sequencing, we sequenced exomes six members a large family affected epilepsy confirmed cosegregation in all 37 members. We screened an additional 310 patients this disorder for variants DNA melting-curve analysis targeted real-time sequencing gene encoding...
Heterozygous mutations in Myoclonin1/EFHC1 cause juvenile myoclonic epilepsy (JME), the most common form of genetic generalized epilepsies, while homozygous F229L mutation is associated with primary intractable infancy. adolescent JME patients produce subtle malformations cortical and subcortical architecture, whereas infancy induces severe brain pathology death. However, underlying pathological mechanisms for these observations remain unknown. We had previously demonstrated that EFHC1 a...
Several cross-sectional studies have demonstrated the relevance of DNA methylation glucocorticoid receptor exon 1F region (GR-1F) for trauma-related psychopathology. We conducted a longitudinal study to examine GR-1F changes over time in relation trauma exposure and development post-deployment (52 loci) was quantified using pyrosequencing whole blood 92 military men 1 month before 6 months after 4-month deployment period Afghanistan. overall (mean number methylated functional (methylation at...
Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) is a common pharmaco-resistant referred for adult surgery. Though associated prolonged febrile seizures (FS) in childhood, the neurobiological basis this relationship not fully understood and currently no preventive or curative therapies are available. DNA methylation, an epigenetic mechanism catalyzed by methyltransferases (DNMTs), potentially plays pivotal role epileptogenesis FS. In attempt to start exploring notion, present...
Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function. However, mechanisms underlying these effects are largely unknown. To unravel mechanisms, we aimed treat APPswe/PS1dE9 mice fluoxetine. Unexpectedly, time, an increased number animals displayed seizure behavior died. Although spontaneous behavioral seizures have been reported previously in this mouse model, observation death consequential treatment new. Our...
Posttraumatic stress disorder (PTSD) is a psychiatric that can develop upon exposure to traumatic event. While most people are able recover promptly, others at increased risk of developing PTSD. However, the exact underlying biological mechanisms differential susceptibility unknown. Identifying biomarkers PTSD could assist in its diagnosis and facilitate treatment planning. Here, we identified serum microRNAs (miRNAs) subjects underwent event aimed assess their potential serve as diagnostic...