A5010570874- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Nuclear Receptors and Signaling
- Nicotinic Acetylcholine Receptors Study
- MicroRNA in disease regulation
- RNA Research and Splicing
- Attention Deficit Hyperactivity Disorder
- Epigenetics and DNA Methylation
- Mental Health Research Topics
- Identity, Memory, and Therapy
- Cannabis and Cannabinoid Research
Allen Institute for Brain Science
2017-2025
Icahn School of Medicine at Mount Sinai
2017-2025
University of Crete
2024
Texas A&M University
2024
Boston University
2024
Rockefeller University
2024
Albert Einstein College of Medicine
2019-2022
Washington University in St. Louis
2022
Institute of Cancer Research
2022
Florida State University
2008-2020
Abstract Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated pathophysiology of depression; however, afferent source this increased glutamate tone is not known. The NAc receives inputs from medial prefrontal cortex (mPFC), ventral hippocampus (vHIP) basolateral amygdala (AMY). Here, we demonstrate that vHIP afferents to regulate susceptibility chronic social defeat stress (CSDS). We observe reduced activity mice...
Abstract Psychosocial stress has profound effects on the body, including immune system and brain 1,2 . Although a large number of pre-clinical clinical studies have linked peripheral alterations to stress-related disorders such as major depressive disorder (MDD) 3 , underlying mechanisms are not well understood. Here we show that expression circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in serum humans with MDD stress-susceptible mice following...
Abstract Most people exposed to stress do not develop depression. Animal models have shown that resilience is an active state requires broad transcriptional adaptations, but how this homeostatic process regulated remains poorly understood. In study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator pro-resilient changes in nucleus accumbens (NAc), a key brain reward region implicated...
Opioid use disorder (OUD) looms as one of the most severe medical crises facing society. More effective therapeutics will require a deeper understanding molecular changes supporting drug-taking and relapse. Here, we develop brain reward circuit-wide atlas opioid-induced transcriptional regulation by combining RNA sequencing (RNA-seq) heroin self-administration in male mice modeling multiple OUD-relevant conditions: acute exposure, chronic intake, context-induced drug-seeking following...
Abstract Stress promotes negative affective states, which include anhedonia and passive coping. While these features are in part mediated by neuroadaptations brain reward circuitry, a comprehensive framework of how stress-induced affect may be encoded within key nodes this circuit is lacking. Here, we show mouse model for coping that phenomena associated with increased synaptic strength ventral hippocampus (VH) excitatory synapses onto D1 medium spiny neurons (D1-MSNs) the nucleus accumbens...
There is a rise in the concurrent use of methylphenidate (MPH) and fluoxetine (FLX) pediatric populations. However, long-term neurobiological consequences combined MPH FLX treatment (MPH + FLX) during juvenile periods are unknown. We administered saline (VEH), MPH, FLX, or to Sprague Dawley male rats from postnatal day 20 34, assessed their reactivity reward- mood-related stimuli 24 h 2 months after drug exposure. also mRNA protein levels within ventral tegmental area (VTA) determine effect...
The mechanisms underlying the enduring neurobiological consequences of antidepressant exposure during adolescence are poorly understood. Here, we assessed long-term effects to fluoxetine (FLX), a selective serotonin reuptake inhibitor, on behavioral reactivity emotion-eliciting stimuli. We administered FLX (10 mg/kg, bi-daily, for 15 d) male adolescent [postnatal day 35 (P35) P49] C57BL/6 mice. Three weeks after treatment (P70), aversive stimuli (i.e., social defeat stress, forced swimming,...
Stressful early life experiences are implicated in lifelong health. However, little is known about the consequences of emotional stress (ES) or physical (PS) on neurobiology. Therefore, following set experiments was designed to assess changes transcription and translation key proteins within nucleus accumbens (NAc). Male adolescent (postnatal day 35) adult (8-week-old) mice were exposed ES PS using a witness social defeat paradigm. Then, 24 h after last session, we measured levels specific...
Animal studies using chronic social defeat stress (CSDS) in mice showed that brain-derived neurotrophic factor (BDNF) signaling the mesolimbic dopamine (DA) circuit is important for development of aversion. However, downstream molecular targets after BDNF release from ventral tegmental area (VTA) DA terminals are unknown. Here, we show depressive-like behaviors induced by CSDS mediated part Gadd45b nucleus accumbens (NAc). We mRNA levels increased susceptible but not resilient mice....
Abstract Major depressive disorder (MDD) is one of the most important causes disability worldwide. While recent work provides insights into molecular alterations in brain patients with MDD, whether these signatures can be associated expression specific symptom domains remains unclear. Here, we identified sex-specific gene modules combining differential and co-expression network analyses six cortical subcortical regions. Our results show varying levels homology between males females across...