A5082252376- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- Signaling Pathways in Disease
- Graphene research and applications
- Advanced Glycation End Products research
- Pluripotent Stem Cells Research
- Cancer Risks and Factors
- Metabolism, Diabetes, and Cancer
University of Fribourg
2018-2020
École Polytechnique Fédérale de Lausanne
2020
Sapienza University of Rome
2015-2016
Obesity is a strong predictor of poor prognosis in breast cancer, especially postmenopausal women. In particular, tumors obese patients tend to seed more distant metastases, although the biology behind this observation remains poorly understood. To elucidate effects microenvironment on metastatic spread, we ovariectomized C57BL/6 J female mice and fed them either regular diet (RD) or high-fat (HFD) generate diet-induced obesity model. We then studied tumor progression metastasis Py230 EO771...
Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also the particular microenvironment supports their growth and modulates plasticity system. In search for microenvironmental factors supporting cell (CSC) tumour progression to metastasis, we here investigated role matricellular protein transforming factor beta induced (TGFBI) in breast cancer. We crossed MMTV-PyMT model mammary gland tumorigenesis with TgfbiΔ/Δ...
Since graphene nanoparticles are attracting increasing interest in relation to medical applications, it is important understand their potential effects on humans. In the present study, we prepared oxide (GO) nanoribbons by oxidative unzipping of single-wall carbon nanotubes (SWCNTs) and analyzed toxicity two human neuroblastoma cell lines. Neuroblastoma most common solid neoplasia children. The hallmark these tumors high number different clinical variables, ranging from highly metastatic,...
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm, and extracellular space. It important DAMP molecule allows communication between damaged or tumor cells immune system. Tumor exploit HMGB1’s ability to activate intracellular pathways lead cell growth migration. Papillary thyroid cancer a well-differentiated often used study relationships inflammatory microenvironment as latter characterized by high levels of cytokines. Anaplastic...
Tumor infiltration by dendritic cells (DCs) has been identified as a biomarker associated with favorable outcomes and improved responses to immunotherapies T cell immune checkpoint blockade. However, tumor induced immunosuppressive pathways contrive efficient DC infiltration. This calls for the development of DC-targeted interventions purposed stimulate local expansion. Here we deliver proof-of-concept cell-based immunotherapeutic approach promoting circulating progenitors in together their...
Cancer stem cells (CSCs) are defined by their ability to regenerate a tumor upon transplantation. However, it is not yet clear whether tumors contain single CSC population or different subsets of with mixed capacities for initiating primary and secondary tumors. Using two identification strategies, we studied the overlap between metastatic tumor-initiating (TICs) in MMTV-PyMT model. Our results show that model, Lin−CD90−ALDHhigh retained high potential (TIP) orthotopic transplants, contrast...
microRNA (miR/miRNA) are small non-coding RNAs that control gene expression at the post-transcriptional level by targeting mRNAs. Aberrant of miRNAs is often observed in different types cancer. Specific function as tumor suppressors or oncogenes and interfere with various aspects carcinogenesis, including differentiation, proliferation invasion. Upregulation 221 222 has been shown to induce a malignant phenotype numerous human cancers via inhibition phosphatase tensin homolog (PTEN)...