A5117176946- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
Immunité et Cancer
2025
Institut Pasteur
2025
<title>Abstract</title> The composition and diversity of tumor-infiltrating CD8<sup>+</sup> T cell populations have important consequences on the development anti-tumor immunity. In a murine model lung cancer, we addressed role dendritic subsets generation various types cells. We show that CD44<sup>+</sup>PD1<sup>-</sup> effector PD1<sup>+</sup>TIM3<sup>+ </sup>exhausted, cells require XCR1<sup>+</sup> DCs but not IRF4-dependent DCs. By contrast, CD103<sup>+</sup>CXCR6<sup>+</sup>...
Tumor infiltration by dendritic cells (DCs) has been identified as a biomarker associated with favorable outcomes and improved responses to immunotherapies T cell immune checkpoint blockade. However, tumor induced immunosuppressive pathways contrive efficient DC infiltration. This calls for the development of DC-targeted interventions purposed stimulate local expansion. Here we deliver proof-of-concept cell-based immunotherapeutic approach promoting circulating progenitors in together their...