A5019366364- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Research on Leishmaniasis Studies
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Parasitic infections in humans and animals
- Trypanosoma species research and implications
- Congenital Anomalies and Fetal Surgery
- Parasites and Host Interactions
- Gut microbiota and health
- Parasite Biology and Host Interactions
- Amoebic Infections and Treatments
- Pancreatic and Hepatic Oncology Research
- Malaria Research and Control
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Metabolomics and Mass Spectrometry Studies
- Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Rabies epidemiology and control
Ege University
2016-2025
Izmir University
2024
The University of Texas MD Anderson Cancer Center
2018-2023
Tabriz University of Medical Sciences
2022
Egerton University
2021
Ege Üniversitesi Tıp Fakültesi Hastanesi
2019-2021
Baylor College of Medicine
2020
TÜBİTAK Marmara Research Center
2019
Boğaziçi University
2010-2016
Singleton Hospital
2008-2012
Breast cancer is the second most common in women. The roles of SIRT and FoxO proteins tumor progression are known, but their metastasis have not yet been clearly elucidated. In our study, we investigated downstream pathways, p21 p53, metastasis. We evaluated these vitro using metastatic 4TLM 67NR cell lines, as well expression levels tumor-bearing mice. addition, regulatory role different transduction cascades was examined by IPA core analysis, clinicopathological evidence TCGA database....
Currently, some Toxoplasma gondii genotypes are being associated with serious clinical presentations. A recent report showing the Africa 1 genotype in two local congenital toxoplasmosis cases acquired Turkey formed basis of this study because atypical is most frequently detected animals and patients from sub-Saharan Africa. Since stray cats considered as linkage between wild life urban T. transmission, present aimed to isolate characterize strains circulating İzmir (Western Turkey)....
Impact of Cytomegalovirus (CMV) co-infection pneumonia in non-HIV patients with Pneumocystis jirovecii (PCP) is unclear.The aim our study was to determine whether CMV associated an increased risk mortality.Our conducted at Ege University Hospital, Turkey. We used molecular assays diagnose respiratory samples, and both blood samples. compared morbidity mortality stratified by status.Between 2009 2015, 43 (mean age: 56.7 ± 15.3 years) were diagnosed PCP. Only 3 had received PCP prophylaxis....
This study investigated the influence of perceived teacher acceptance, children’s self-concept, and attitude toward school on academic achievement. The sample included 223 fifth-grade students in Istanbul, Turkey. Teacher Acceptance-Rejection/Control Questionnaire, Piers-Harris Self-Concept Scale, School Attitude Assessment Survey-Revised were utilized data collection. Achievement was assessed by grade point average (GPA). Results showed that perception acceptance significantly correlated...
Toxoplasma gondii causes congenital toxoplasmosis in newborns resulting with fetal anomalies. Determining the initiation time of infection is very important for pregnant women and current serological assays have drawbacks distinguishing recently acute toxoplasmosis. Diagnosis may be improved by using stage specific antigens assays. In present study, diagnostic value sporozoite SporoSAG, bradyzoite BAG1 proteins GRA1 protein expressed all forms parasite been evaluated ELISA sera...
Cutaneous Leishmaniasis (CL), a neglected vector-borne disease caused by protozoan parasite Leishmania major (L. major), is public health concern, and the development of new strategies to reduce incidence has become top priority. Advances in immunoinformatics in-silico epitope prediction could be promising approach designing finest vaccine candidate. In this study, we aimed design peptide-based against CL using computational tools identified ten B-cell-derived T-cell epitopes from...
KRAS is one of the most frequently mutated proto-oncogenes in pancreatic ductal adenocarcinoma (PDAC) and aberrantly activated triple-negative breast cancer (TNBC). A profound role microRNAs (miRNAs) pathogenesis human being uncovered, including therapy. Using silico prediction algorithms, we identified miR-873 as a potential regulator KRAS, investigated its PDAC TNBC. We found that reduced expression associated with shorter patient survival both cancers. significantly repressed TNBC cell...
Cryptosporidium spp. is an opportunistic protozoan parasite that primarily affects immunocompromised individuals, including those with colorectal cancer (CRC). This study investigates the prevalence and clinical significance of in CRC patients, both gastrointestinal respiratory systems. A total 108 patients 102 healthy controls were enrolled, stool, sputum, saliva samples analyzed using microscopy qPCR methods. detected 13% patients’ stool samples, compared to 2% control group, demonstrating...
The pancreas, previously considered a sterile organ, has recently been shown to harbor its own microbiota that may influence tumor biology and patient outcomes. Despite increasing interest in the impact of microbiome on cancer, relationship between pancreatic tissue oral microbiomes ductal adenocarcinoma (PDAC) remains limited. In this study, pancreas patients with PDAC were compared other periampullary cancers (DC/AC) healthy control group using 16S rRNA gene sequence analysis. results...
Tumor-associated macrophages (TAMs) significantly influence tumor progression and patient responses to conventional chemotherapy. However, the interplay between anti-cancer drugs, immune in microenvironment, their implications for cancer treatment remains poorly understood. This study investigates effects of vinorelbine on M2 lung its capacity modulate TAMs toward an M1 phenotype. Peripheral blood mononuclear cells (PBMCs) were polarized into macrophages, subsequent phenotype alterations...
Intestinal protozoan parasites are common causes of infectious diarrhea in children receiving anticancer therapy or undergoing transplantation. Additionally, immunosuppression such patients may exacerbate the symptoms related to these parasitic infections. The aim this study was evaluate prevalence and diagnostic importance infections treated for malignancies transplantation, highlight control intestinal immunosuppressed at a hospital İzmir, Turkey. In total, 82 stool samples from 62 were...
Routine laboratory diagnosis of Pneumocystis jirovecii is currently achieved by PCR in almost all laboratories with sufficient equipment due to its high sensitivity and specificity compared staining methods. A current issue that limits the reliability degree inhibition caused inhibitory substances respiratory samples. The present study aimed analyse frequency real-time detecting P. specimens submitted a pneumonia (PcP) Ege University Medical School, Turkey. Between July 2009 December 2010,...
Acquisition of acute toxoplasmosis during the first trimester pregnancy can have catastrophic consequences for foetus. Diagnosis is routinely based on detection maternal Toxoplasma gondii--antibodies using whole parasite extracts as antigen. While such assays are sensitive, they show no specificity stage infection. We hypothesized diagnosis might be improved recombinant antigens detection, particularly if antibodies to certain antigen(s) were associated with early or late stages To address...
Toxoplasmosis is a serious and potentially life-threatening disease in liver transplant recipients while they are immunosuppressed. We report the clinical laboratory findings related to active toxoplasma infection associated with 40 immunosuppressed procedures that took place over 12-month period at major unit Izmir, Turkey. Twenty-seven (67.5%) of were found be seropositive for therefore risk reactivated infection. From serological status donors, which was ascertained 38 cases, we...
Aim: To investigate the role of EF2K in BRCA1-mutated breast cancer. Materials & methods: We developed silica coated cobalt-ferrite (CoFe) nanoparticles for vivo delivery small interfering RNAs (siRNAs) into Results: Expression is highly upregulated majority (78.5%) patients and significantly associated with poor patient survival metastasis. Silencing reduced cell proliferation, migration invasion cancer cells. In therapeutic targeting by CoFe-siRNA-nanoparticles leads to sustained gene...