A5086182493- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Social and Educational Sciences
- Education, Healthcare and Sociology Research
- RNA and protein synthesis mechanisms
- Empathy and Medical Education
- Plant Virus Research Studies
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
Linköping University
2002-2008
Innsbruck Medical University
2008
Methylation of the N-terminal region histones was first described more than 35 years ago, but its biological significance has remained unclear. Proposed functions range from transcriptional regulation to higher order packing chromatin in progress mitotic condensation. Primarily because recent discovery SET domain-depending H3-specific histone methyltransferases SUV39H1 and Suv39h1, which selectively methylate lysine 9 H3 N terminus, this posttranslational modification regained scientific...
Posttranslational modification of histones is a common means regulating chromatin structure and thus diverse nuclear processes. Using hydrophilic interaction liquid chromatographic separation method in combination with mass spectrometric analysis, the present study investigated alterations histone H4 methylation/acetylation status interplay between methylation acetylation during vitro differentiation mouse erythroleukemia cells how these modifications affect structure. Independently type...
The replacement linker histones H1<sup>0</sup> and H5 are present in frog chicken erythrocytes, respectively, their accumulation coincides with cessation of proliferation compaction chromatin. These cells have been analyzed for the affinity chromatin cytochemical biochemical methods. Our results show a stronger association between erythrocyte nuclei than nuclei. Analyses from erythrocytes using capillary electrophoresis showed to be subtype strongest associated corresponding analyses...
Histone H1 is a family of nucleosomal proteins that exist in number subtypes. These subtypes can be modified after translation various ways, above all by phosphorylation. Increasing levels phosphorylation has been correlated with cell cycle progression, while both and dephosphorylation histone have linked to the apoptotic process. Such conflicting results may depend on which apoptosis-inducing agents cause apoptosis via different pathways often interfere proliferation. Therefore, we...