A5008729657- Neurological Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Nutrition, Genetics, and Disease
- Biomarkers in Disease Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Diet, Metabolism, and Disease
- Cardiac Ischemia and Reperfusion
- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Wound Healing and Treatments
- Photoreceptor and optogenetics research
- Diet and metabolism studies
- Cancer Research and Treatments
- Redox biology and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Horticultural and Viticultural Research
- CRISPR and Genetic Engineering
- Medicinal Plants and Bioactive Compounds
- BRCA gene mutations in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced biosensing and bioanalysis techniques
- Atherosclerosis and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Insect Resistance and Genetics
- Lipid metabolism and biosynthesis
V.I. Vernadsky Crimean Federal University
2017-2023
Research Institute of Agriculture of Crimea
2016-2022
Crimea State Medical University named after S. I. Georgievsky
2020-2021
Stavropol State Medical University
2021
At the population level, virus-host relationship is not set up to end with complete elimination of either or both. Pathogen-resistant individuals will always remain in host population. In turn, virus can never completely eliminate population, because evolutionarily such an event a dead for as obligate intracellular parasite. A certain existential balance exists relationship. Against this backdrop, viral epidemics and pandemics only become manifest egregious human beings when tens hundreds...
During the current COVID-19 pandemic, global ratio between dead and survivors is approximately 1 to 10, which has put humanity on high alert provided strong motivation for intensive search vaccines drugs. It already clear that if we follow most likely scenario, similar used create seasonal influenza vaccines, then will need develop improved vaccine formulas every year control spread of new, highly mutable coronavirus SARS-CoV-2. In this article, using well-known RNA viruses (HIV, viruses,...
Having observed how botanicals and other natural compounds are used by nature to control pests in the environment, we began investigating polymers, DNA RNA, as promising tools for insect pest management. Over last decade, unmodified short antisense oligonucleotides have shown a clear potential use insecticides. Our research has concentrated mainly on Lymantria dispar larvae using an oligoRING sequence from its inhibitor-of-apoptosis gene. In this article, propose novel biotechnology protect...
Abstract Background The development of persistent endoplasmic reticulum (ER) stress is one the cornerstones prostate carcinogenesis; however, mechanism missing. Also, alcohol a physiological ER inducer, and link between alcoholism progression cancer (PCa) well documented but not characterized. According to canonical model, mediator stress, ATF6, cleaved sequentially in Golgi by S1P S2P proteases; thereafter, genes responsible for unfolded protein response (UPR) undergo transactivation....
Baculovirus IAP (inhibitor-of-apoptosis) genes originated by capture of host genes. Unmodified short antisense DNA oligonucleotides (oligoDNAs) from baculovirus can down-regulate specific gene expression profiles in both baculovirus-free and baculovirus-infected insects. In this study, gypsy moth (Lymantria dispar) larvae infected with multiple nucleopolyhedrovirus (LdMNPV), LdMNPV-free larvae, were treated oligoDNA to the RING (really interesting new gene) domain LdMNPV IAP-3 gene. The...
Current experimental research has proven the efficacy of transplantation bone marrow-derived mesenchymal stem cells (MSC) in treatment myocardial infarction (MI). The one main purposes was to evaluate comparative data MSC with (5-azacytidine) and without commitment assess post effects.The efficiency intravenous cardiomyoplasty by infusion evaluated female Wistar-Kyoto rats model using echocardiography, morphological study, morphometry, immunohistostaining, from situ hybridization,...
The urgency of the search for inexpensive and effective drugs with localized action treatment rheumatoid arthritis continues unabated. In this study, first time we investigated Cytos-11 antisense oligonucleotide suppression TNF-α gene expression in a rat model induced by complete Freund’s adjuvant. has been shown to effectively reduce peripheral blood concentrations TNF-α, joint inflammation, pannus development. results achieved following were similar those adalimumab (Humira®); they also...
In recent years, as cardiovascular mortality is increasing, the interest in studying influence of polyphenol-rich grape products (PRGP) on risks constantly growing.The estimation a safe and effective dose PRGP deserves special attention, because an excessive consumption can lead to endothelial dysfunction oxidative stress.The hygienic curative properties young branches grapevine, leaves, berries, juice wine are used traditional medicine for long time.The grapes known be due presence...
The role played by hereditary factors in the development of diabetes mellitus type 2 (DM2) has not yet been fully established. Therefore, purpose our study was to investigate prevalence adiponectin and polymorphism its gene receptors connection with primary symptoms DM2 pathogenesis. Genomic DNA isolated from whole blood 94 patients an established diagnosis using phenol-chloroform method. Gene polymorphisms were determined real-time polymerase chain reaction (PCR). most common polymorphic...
Purpose: to evaluate the interrelationships of proinflammatory cytokines serum levels with development acute myocardial infarction (MI) complications. Materials and methods. Eighty two patients AMI were studied. Prospective short-term study included, uncomplicated non-Q wave MI (n = 27), Q-wave complicated by left ventricular insufficiency Killip class I–II 30), III–IV 17), non-survivors due cardiogenic shock 8) age gender matched healthy controls 12). Serum IL-1β, IL-6 TNF-α had been...
Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in development of metabolic syndrome (MS). The purpose this study was to analyse frequency which polymorphic loci adiponectin (ADIPOQ) and leptin (LEP) genes occur patients MS association between symptoms these polymorphisms. DNA isolated from whole blood 207 100 healthy individuals (control group) using phenol-chloroform method. Gene polymorphisms were determined real-time polymerase chain reaction...
SARS-CoV-2 is a new representative of the world virology related to coronaviruses and can cause wide range diseases respiratory system: from colds acute distress-syndrome with severe failure. The pathogenesis coronavirus infection (COVID-19) associated ability bind ACE receptors subsequently activate IL-6, main stimulator “cytokine storm”. Due such features viral pathogenesis, early accurate detection active forms, as well virus carriage are needed. In review, whole spectrum diagnostic...
A wide range of anti-inflammatory properties the solution nanosilver has found its application in medical practice. In this work, nano-silver was used treatment burn wounds combination with a proteinase inhibitor. An experimental model second-degree use therapy is accompanied by decrease inhibitory potential at local level and stimulation regeneration processes, which indicates effects particles. There also morphological signs inflammation burned areas skin therapeutic nano-silver. The...
кЛИНИЧЕСкИЙ СЛУЧАЙ пЕРВИЧНО-мНОЖЕСтВЕННОГО мЕтАХРОННОГО Brca-АССОЦИИРОВАННОГО РАкА Г. м
Type 2 diabetes mellitus (DM2) is the ninth leading cause of worldwide mortality. To predict likelihood disease and its unfavorable clinical course with developing complications, it necessary to consider genetic molecular factors DM2 pathogenesis. Therefore, aim this review was analyze role that belongs in mechanisms development establish most significant single nucleotide polymorphisms (SNP) The authors have analyzed literature sources found such databases as CYBERLENINKA, E-library,...