A5064873024- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Biomarkers in Disease Mechanisms
- Cardiovascular Disease and Adiposity
- Medicinal Plants and Bioactive Compounds
- Neurological Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammation biomarkers and pathways
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Apelin-related biomedical research
- Digestive system and related health
- Chemical Reactions and Isotopes
- Cardiac Ischemia and Reperfusion
- Synthesis and Characterization of Heterocyclic Compounds
- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Acute Myocardial Infarction Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Antioxidant Activity and Oxidative Stress
- Cardiac Imaging and Diagnostics
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
V.I. Vernadsky Crimean Federal University
2017-2023
Research Institute of Agriculture of Crimea
2017-2022
Oral mucosa atrophy is a widespread phenomenon both in prosthetics and the maxillofacial pathology, having apoptosis as fundamental mechanism. Modeling of processes will allow to study its pathogenesis optimize therapeutic measures. The aim was investigate development oral an experimental model. performed on 50 Wistar male rats, undergone 37% orthophosphoric acid applications. After 30 seconds’ exposure defect integumentary epithelium found. 40-second 45-second additionally provoked...
In recent years, as cardiovascular mortality is increasing, the interest in studying influence of polyphenol-rich grape products (PRGP) on risks constantly growing.The estimation a safe and effective dose PRGP deserves special attention, because an excessive consumption can lead to endothelial dysfunction oxidative stress.The hygienic curative properties young branches grapevine, leaves, berries, juice wine are used traditional medicine for long time.The grapes known be due presence...
The role played by hereditary factors in the development of diabetes mellitus type 2 (DM2) has not yet been fully established. Therefore, purpose our study was to investigate prevalence adiponectin and polymorphism its gene receptors connection with primary symptoms DM2 pathogenesis. Genomic DNA isolated from whole blood 94 patients an established diagnosis using phenol-chloroform method. Gene polymorphisms were determined real-time polymerase chain reaction (PCR). most common polymorphic...
Highlights . The article presents a review of literature data on the diagnostic role endothelial dysfunction biomarkers. provides an overview main indicators, their significance in various pathologies, and possible therapeutic strategies for preventing dysfunction. Abstract Endothelial is characteristic feature each stage cardiovascular continuum – series events from hypertension to development atherosclerosis coronary heart disease, thrombus formation, myocardial infarction, failure. Due...
Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in development of metabolic syndrome (MS). The purpose this study was to analyse frequency which polymorphic loci adiponectin (ADIPOQ) and leptin (LEP) genes occur patients MS association between symptoms these polymorphisms. DNA isolated from whole blood 207 100 healthy individuals (control group) using phenol-chloroform method. Gene polymorphisms were determined real-time polymerase chain reaction...
Tuberculosis (TB) remains one of the most dangerous infections with high mortality in whole world. The leading problems modern course TB are both long-term therapy and appearance multiplying wide resistant forms, as well rise comorbid pathology (e.g. AIDS-associated TB). Nonefficient antibiotic forces search alternative ways treatment. Prospective among existent ones is "target therapy" aimed on key links a host organism. aim our study was to determine morphofunctional characteristics VEGF-A...
Aim of this study was to evaluate the effects total thyroid resection on exocrine pancreatic ultrastructure in both early and late stages hypothyroidism experiment. Material Methods — The experimental carried out 40 mature white male rats weight 180 200 g divided into two groups: group I – intact rats, which were kept normal vivarium conditions (control group) II with modelled by thyroidectomy. At 14th 100th day after thyroidectomy animals groups sacrificed under thiopental sodium anesthesia...
Introduction. Coronary heart disease is a common pathology, playing key role in cardiovascular mortality. Damage of circulatory system affects people all ages, including the active population, which provides an adverse impact on socio-economic state society. In this research, we analyzed processes cardiomyocyte apoptosis and their effects myocardial ischemic damage. Aim was to identify development coronary disease. Materials Methods. A meta-analysis 50 literary sources performed PubMed...
Type 2 diabetes mellitus (DM2) is the ninth leading cause of worldwide mortality. To predict likelihood disease and its unfavorable clinical course with developing complications, it necessary to consider genetic molecular factors DM2 pathogenesis. Therefore, aim this review was analyze role that belongs in mechanisms development establish most significant single nucleotide polymorphisms (SNP) The authors have analyzed literature sources found such databases as CYBERLENINKA, E-library,...
Objective — Biological effects of grape processing products (GPP) rich in polyphenols are still not studied completely. The aim the investigation was to study co-interactions between peroxidation lipid oxidation (PLO) and nonspecific proteases their inhibitors activity animals with model metabolic syndrome (MS) corrected GPP. Material Methods performed on 54 white male rats weight 180-200 g. experimental groups were fed by standard menu given 10% fructose solution instead drinking water...
The article presents the results of study effect polyphenol-rich materials obtained from grapes on clinical symptoms, activity non-specific proteases, and parameters lipid peroxidation (LPO) blood rats with fructose model metabolic syndrome (MS). White male (n=54, initial body weight 190-210 g) were randomly divided into five groups: control 4 experimental groups. Body weight, circumference abdomen, serum level glucose, total cholesterol, triglycerides high density (HDL) lipoproteins...
The aim of the work was to study influence sparkling wines on main markers hypoxia. Material and methods. experiment carried out 25 white male rats weighing 180–200 grams (age 10–12 weeks.). Animals group 1 were control animals received drinking water. second water subjected bloodletting 1st week. 3rd week diluted wine as 4 not throughout experiment. Sparkling given at a dose 300 ml per 70 kg body weight. In blood serum, free radical oxidation inflammation formed in hypoxic damage studied....
На 82 белых крысах линии Wistar получены данные о связи воспалительных изменений в крови и ткани головного мозга крыс с уровнем экспрессии мозгового нейротрофического фактора (BDNF), распределением нейрональной NO-синтазы (nNOS) головном мозге степенью
BACKGROUND: Metabolic syndrome (MS) causes the risk of serious diseases development e.g. type 2 diabetes mellitus and cardiovascular disasters. Timely adequate correction MS can reduce heart disease AIM: To investigate drugs for its on morphofunctional state muscle large blood vessels. MATERIALS AND METODS: A comparative analysis disorders in system fructose model adult (n=32) young (n=50) Wistar rats was performed. The duration feeding 24 weeks animals 16 Mature due to their different...
An experimental study was carried out on 30 white male rats using the fructose model of metabolic syndrome (MS).For 12 weeks, animals from group (n=10) received in addition to diet polyphenolic product grape processing «Fanocor».It found that size adipocytes abdominal fatty tissue with (MS) exceeded those control by 2.1 times (p<0.05).The distribution curve MS characterized significant variability and a shift towards general increase size.The correction «Fanocor» resulted decrease fat cells...
ИзуЧЕНИЕ РОЛИ ДИСМЕТАБОЛИЧЕСКИХ МЕХАНИзМОВ В РАзВИТИИ НЕйРОДЕГЕНЕРАТИВНЫХ пРОЦЕССОВ пРИ ЭКСпЕРИМЕНТАЛЬНОМ МОДЕЛИРОВАНИИ МЕТАБОЛИКО-КОГНИТИВНОГО СИНДРОМА В. И. петренко 1 , А. Шевандова Кубышкин Фомочкина Ю. Шрамко Т. п.Макалиш Огай 2 Д. Р. Хусаинов 3 Медицинская академия им.С. Георгиевского Крымского федерального университета им.В. Вернадского, Симферополь, Российская Федерация Всероссийский национальный научно-исследовательский институт виноградарства и виноделия, Ялта, Таврическая им
Purpose. The aim of the review is to analyze modern data on molecular mechanisms stomach and intestinal carcinogenesis, which can be basis for managing malignant intestine neoplasms mortality risks’ reduction.
 Materials methods. includes from foreign domestic studies published in electronic bibliographic databases PubMed, Cyberleninka, Elibrary over past 10 years.
 Results. It given analysis Wnt β-catenin gene family role pathogenesis colon tumors carcinogenic potential...
Introduction. Endothelial dysfunction is a key link in the atherosclerotic process and therefore study of specific markers may provide new opportunities for development therapeutic strategies its correction. Aim this work was to role biomarkers endothelial (endocan endoglin) early detection prognosis cardiovascular pathology. Material methods. Meta-analysis literature sources scientific electronic bibliographic databases PubMed Social Sciences Citation Index carried out. Results discussion....
мОРФОФУНКЦИОНАЛЬНЫЕ ИЗмЕНЕНИЯ ПЕЧЕНИ И СОСТОЯНИЕ СИСТЕмЫ КОАГУЛЯЦИИ КРОВИ КРЫСЫ ПРИ РАЗВИТИИ РЕПЕРФУЗИОННОГО СИНДРОмА А. Писарев 1 , Л. В. Анисимова И. Фомочкина Кубышкин Д. С. Кузичкин 2 Ю. Шрамко З. Харченко Е. П. Голубинская медицинская академия им.С. Георгиевского Крымского федерального университета им.В. Вернадского, Симферополь, Российская Федерация Институт медико-биологических проблем РАН, москва, ФедерацияDisseminated intravascular coagulation leads to the development of multiple...
Adipose tissue in obesity produces more active oxygen forms and inflammatory cytokines, which results the development of a systemic response syndrome (SIRS) metabolic (MS). Recently, there has been growing interest natural products for oxidative stress remodeling. Therefore, it is relevant to study grape polyphenols (GPs) develop certain techniques prevention treatment. The goal paper examine antioxidant profiles MS, efficacy its pathogenetic correction with GPs. Materials Methods. authors...
For all tumors, regardless of type and tissue, there are a number common features. These include high proliferative activity, disturbances in the mechanisms apoptosis "invisibility" for cells immune system. At basis these disorders lies malfunction interaction between signaling proteins inside cell, due to violation expression genes responsible their synthesis. The aim review is study molecular biological carcinogenesis, characteristics features tumor that affect development disease,...
Adipose tissue in abdominal obesity produces various cytokines, the most important of which is adiponectin (AN). Polymorphism AN receptor genes associated with risk metabolic syndrome (MS) and type 2 diabetes mellitus (DM2) development. The aim study was to investigate association receptors’ polymorphism development MS DM2 Republic Crimea as well possibility named pathology correction polyphenolic functional foods. included 100 patients confirmed diagnosis MS. Genomic DNA isolated from whole...