A5090520820- Mast cells and histamine
- Gastrointestinal motility and disorders
- Animal Nutrition and Physiology
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Stress Responses and Cortisol
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Barrier Structure and Function Studies
- Animal Behavior and Welfare Studies
- Neuroendocrine regulation and behavior
- Meat and Animal Product Quality
- Food Allergy and Anaphylaxis Research
- Tryptophan and brain disorders
- Birth, Development, and Health
- Animal Virus Infections Studies
- Diet and metabolism studies
- Agriculture Sustainability and Environmental Impact
- Clinical Nutrition and Gastroenterology
- Urticaria and Related Conditions
- Infant Health and Development
- Ion Transport and Channel Regulation
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
Michigan State University
2016-2025
Michigan Department of Agriculture and Rural Development
2020-2022
Michigan United
2017
North Carolina State University
2007-2016
Early life stress is a predisposing factor for the development of chronic intestinal disorders in adult life. Here, we show that associated with early weaning pigs leads to impaired mucosal barrier function. (15- 21-day age) resulted sustained impairment function, as indicated by reductions jejunal transepithelial electrical resistance and elevations mucosal-to-serosal flux paracellular probes [ 3 H]mannitol 14 C]inulin measured at 5 9 wk age, compared shown late-weaned (23- 28-day age)....
ABSTRACT Swine are an important source of proteins worldwide but subject to frequent viral outbreaks and numerous infections capable infecting humans. Modern farming conditions may also increase transmission potential zoonotic spread. We describe here the metagenomics-derived virome in feces 24 healthy 12 diarrheic piglets on a high-density farm. An average 4.2 different mammalian viruses were shed by piglets, reflecting high level asymptomatic infections. Diarrheic pigs 5.4 viruses....
Background and Aims The clinical onset severity of intestinal disorders in humans animals can be profoundly impacted by early life stress. Here we investigated the impact weaning stress pigs on physiology, disease, immune response to subsequent challenge with enterotoxigenic F18 E. coli (ETEC). Methodology Pigs weaned from their dam at 16 d, 18 20 d age were given a direct oral ETEC 26 age. monitored days 0 4 post-infection for signs disease. On Day post-ETEC challenge, ileal barrier...
Weaning in the piglet is a stressful event associated with gastrointestinal disorders and increased disease susceptibility. Although stress thought to play role postweaning intestinal disease, mechanisms by which influences pathophysiology weaned pig are not understood. The objectives of these experiments were investigate impact weaning on health assess signaling pathways this response. Nineteen-day-old pigs weaned, mucosal barrier function ion transport assessed jejunal colonic tissues...
Our previous work has demonstrated that weaning at 19 days of age deleterious effects on mucosal barrier function in piglet intestine are mediated through peripheral CRF receptor signaling pathways. The objectives the present study were to assess impact weaning-associated intestinal dysfunction and determine role mast cells play weaning-induced breakdown function. Nursing Yorkshire-cross piglets either weaned (early-weaned, n = 8) or 28 (late-weaned, housed nursery pens. Twenty-four hours...
Background and Aims Psychological stress is a predisposing factor in the onset exacerbation of important gastrointestinal diseases including irritable bowel syndrome (IBS) inflammatory (IBD). The pathophysiology stress-induced intestinal disturbances known to be mediated by corticotropin releasing (CRF) but precise signaling pathways remain poorly understood. Utilizing porcine ex vivo model, aim this study was investigate mechanisms which CRF mediates epithelial barrier disturbances....
Early life adversity (ELA) is a risk factor for development of gastrointestinal disorders later in life. The underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood.Utilizing porcine early weaning stress (EWS) model mimic ELA, we investigated the long-term effects EWS on functional diarrhea, ileal permeability, mast cell activity relationship with enteric ganglia.Juvenile adult pigs exhibited chronic, diarrhea (EWS 43.6% vs late...
Intake of colostrum after birth is essential to stimulate intestinal growth and function, provide systemic immunological protection via absorption Immunoglobulin G (IgG). The order weight 745 piglets (from 75 litters) were recorded during a one-week period farrowing. Only pigs weighing greater than 0.68 kg chosen for the trial. Sow was collected parturition, bled between 48 72 hours post-birth. Piglet serum IgG colostral concentrations determined by radial immunodiffusion.Sow parity had...
Creep feeding is used to stimulate piglet post-weaning feed consumption. L-Glutamine (GLN) an important source of fuel for intestinal epithelial cells. The objective this study was determine the impact creep and adding GLN or AminoGut (AG; containing glutamine + glutamate) pre- diets on pig performance health. Litters (N = 120) were allotted four treatments during 14-21 d lactation: 1) No (NC, n 45); 2) fed control diet (CFCD, 3) 1% (CFGLN, 15); 4) .88% AG (CFAG, 15). After weaning, NC CFCD...
Biological sex plays a prominent role in the prevalence and severity of number important stress-related gastrointestinal immune-related diseases including IBS allergy/anaphylaxis. Despite establishment differences these diseases, underlying mechanisms contributing to remain poorly understood. The objective this study was define biological on mast cells (MCs), an innate immune cell central pathophysiology many GI allergic disorders. Twelve-week-old C57BL/6 male female mice were exposed...
Abstract The objective of this study was to investigate the effect increasing degrees lipid peroxidation on structure and function small intestine nursery pigs. A total 216 pigs (mean body weight 6·5 kg) were randomly allotted within blocks sex fed one five experimental diets for 35 d (eleven pens per treatment with three four pen). Treatments included a control diet without added lipid, supplemented 6 % soyabean oil that exposed heat (80°C) constant oxygen flow (1 litre/min) 0, 6, 9 12 d....
Psychosocial stress is a major factor driving gastrointestinal (GI) pathophysiology and disease susceptibility in humans animals. The mechanisms governing to stress-induced GI remain poorly understood. In the present study, we investigated influence of chronic social (CSS) pigs, induced by 7 d mixing/crowding stress, on intestinal barrier nutrient transport function, corticotropin releasing (CRF) signaling immunological responses. Results from this study showed that CSS resulted significant...
Abstract Immune cells play a critical role in the transition from acute to chronic pain. However, of mast pain remains underinvestigated. Here, we demonstrated that resolution inflammatory is markedly delayed cell–deficient mice. In response complete Freund adjuvant, mice showed greater levels nitric oxide, leukocyte infiltration, and altered cytokine/chemokine profile inflamed skin both sexes. wild-type mice, number cell cell–derived chymases, chymase 1 (CMA1) protease 4 (MCPT4), increased...
Previous studies utilizing an ex vivo porcine model of intestinal ischemic injury demonstrated that prostaglandin (PG)E 2 stimulates repair mucosal barrier function via a mechanism involving Cl − secretion and reductions in paracellular permeability. Further experiments revealed the signaling for PGE -induced recovery was mediated type-2 channels (ClC-2). Therefore, objective present study to directly investigate role ClC-2 by evaluating ischemia-injured mucosa treated with selective agonist...