A5048713524- Botulinum Toxin and Related Neurological Disorders
- Neurotransmitter Receptor Influence on Behavior
- Viral Infections and Immunology Research
- Diabetic Foot Ulcer Assessment and Management
- Forensic Toxicology and Drug Analysis
- Healthcare during COVID-19 Pandemic
- Animal Virus Infections Studies
- Musculoskeletal pain and rehabilitation
- Peripheral Neuropathies and Disorders
- Public Health in Brazil
- Nutrition and Health in Aging
- Youth, Drugs, and Violence
- Extracellular vesicles in disease
- Carcinogens and Genotoxicity Assessment
- Social and Political Issues
- Spine and Intervertebral Disc Pathology
- Migration, Aging, and Tourism Studies
- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Frailty in Older Adults
- Neurological and metabolic disorders
- Pain Management and Opioid Use
- Cannabis and Cannabinoid Research
- Health Education and Validation
- Pain Mechanisms and Treatments
Universidade Federal da Bahia
2025
Hospital Regional de Presidente Prudente
2025
Hospital Israelita Albert Einstein
2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024-2025
Hospital de São João
2004-2024
Universidade Federal do Pará
2024
Pontifícia Universidade Católica de Minas Gerais
2024
Universidade do Porto
2014-2023
National Institute of Health Dr. Ricardo Jorge
2018-2023
Physiologie de la Reproduction et des Comportements
2002-2023
The Salmonella Rck outer membrane protein binds to the cell surface, which leads bacterial internalization via a Zipper mechanism. This invasion process requires induction of cellular signals, including phosphorylation tyrosine proteins, and activation c-Src PI3K, arises as result an interaction with host surface receptor. In this study, epidermal growth factor receptor (EGFR) was identified signaling required for Rck-mediated adhesion internalization. First, were shown be altered when EGFR...
The aging population presents numerous challenges and the design management of living environments are not an exception. This literature review analysis brings together topics related to environment concept sustainability. article existing concepts that applied planning for elderly, including (i) all, (ii) universal design, (iii) inclusive design. Furthermore, this highlights aspects sustainability peculiarities should be taken into account in their environment. Key points sustainable...
Integrating alternative medicine into palliative care presents unique opportunities and challenges for healthcare providers. This article examines two clinical cases that illustrate the complexities of navigating patient preferences therapies within evidence-based care. The first case involves a 50-year-old woman with metastatic breast cancer who prioritized use herbal poultices natural remedies following her faith as Seventh-day Adventist. Despite initial resistance to conventional...
Objective: To report two newborn cases, one with retinal vascular changes and both sensorineural hearing loss, which development factor could be neonatal polycythemia. Case Description. 01. A full-term newborn, without signs of perinatal asphyxia, developed symptomatic polycythemia on the second day life was treated parenteral hydration. After 02 days, it occlusion left vein failed screening test, persisted in subsequent evaluations. 02. life, Neonatal normal, however, when repeated after...
Baclofen is a medication that helps manage muscle spasticity by targeting gamma-aminobutyric acid B receptors in the nervous system. Discontinuing baclofen therapy generally leads to recurrence of baseline and rigidity; however, abrupt cessation may also result neurological, autonomic, psychiatric symptoms. withdrawal syndrome one most serious complications therapy, with potential for rapid progression significant morbidity mortality. Prompt recognition effective treatment are crucial. We...
Objetivo: Avaliar a segurança e eficácia da duodenopancreatectomia parcial ampliada (DPPA) no tratamento de úlceras duodenais perfuradas recidivantes, investigando principalmente taxa recidiva morbimortalidade pós-operatória. Métodos: Foram incluídos 6 estudos retrospectivos prospectivos (n = 613 pacientes) que compararam DPPA com técnicas cirúrgicas convencionais (por exemplo, patch Graham antrectomia). A busca sistemática ocorreu em PubMed, Scopus, Web of Science outras fontes, sem...
Objetivo: Comparar a eficácia da cirurgia metabólica com o uso isolado de agonistas do GLP-1 (por exemplo, liraglutida e semaglutida) para remissão sustentada diabetes tipo 2 em indivíduos obesidade grau I ou II. Métodos: Nove ensaios clínicos randomizados (ECRs), totalizando 1.842 pacientes, foram incluídos após busca bases como PubMed, Embase Cochrane Library. A principal medida desfecho foi taxa DM2, definida por hemoglobina glicada (HbA1c) < 6,5% sem medicação hipoglicemiante...
Objetivo: Avaliar comparativamente a sobrevida e qualidade de vida em pacientes com pé diabético complicado submetidos amputações maiores (acima do tornozelo) versus menores (digital, transmetatarsiana ou abaixo tornozelo). Métodos: Foi realizada uma meta-análise incluindo 12 estudos (observacionais ensaios clínicos) envolvendo 4.185 estágios avançados. A busca abrangente contemplou as bases dados PubMed, Scopus, Web of Science Biblioteca Virtual Saúde, sem restrição data. As medidas efeito...
Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity specificity clinical score predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing. Methods Thirty‐seven with NORSE from Autoimmune Encephalitis Network were investigated brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, complementary testing tissue‐based assays...
Tetanus remains a serious problem in public health, particularly developing countries, despite efficient prevention programs. A retrospective study was conducted at an infectious diseases intensive care unit during 1998-2003 involving patients admitted with grade III tetanus. The aim of the to evaluate efficacy and safety intrathecal baclofen for treatment Lumbar puncture performed, subarachnoid catheter inserted drug administration. An bolus followed by continuous infusion 20 microg/h,...
Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity low doses minimal side effects but are not free from complications. We aimed to evaluate the efficacy safety intrathecal as well patients' satisfaction.Retrospective cohort study including all placed up December 2015. Demographic characteristics, clinical diagnoses, date placement or withdrawal/replacement pumps, dosage...
Ageing is accompanied with a decline in several physiological systems. Frailty an age-related syndrome correlated to the loss of homeostasis and increased vulnerability stressors, which associated increase risk disability, comorbidity, hospitalisation, death older adults. The aim this study was understand relationship between frailty syndrome, immune activation, oxidative stress. Serum concentrations vitamins A E were also evaluated, as well inflammatory biomarkers (CRP IL-6) DNA levels....
Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, major component human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has associated impaired immune function risk mortality older population. The objective this study was to analyze relation between viremia, physical frailty, cognitive impairment.TTV measured 1,131 nonfrail, 45 physically frail, 113...