A5039679340- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- Injury Epidemiology and Prevention
- RNA regulation and disease
- Agricultural and Food Sciences
- Williams Syndrome Research
Universidade Federal do Recôncavo da Bahia
2016-2024
Escola Bahiana de Medicina e Saúde Pública
2018-2023
Complexo Hospitalar Universitário Professor Edgard Santos
2015-2023
Universidade Federal da Bahia
2014-2017
Broad Institute
2016
Brigham and Women's Hospital
2016
Universidade do Estado da Bahia
2013
Hospital das Clínicas da Universidade Federal de Minas Gerais
2003
Abstract Despite treatment with valproic acid and neuroleptics, a significant proportion of patients Sydenham chorea (SC) remain chorea. We evaluated the effect intravenous methyl‐prednisolone followed by oral prednisone in SC refractory to conventional treatment. Patients were enrolled study if they failed improve treatment, despite development side effects. Chorea was rated on 0 4 score. Five patients, 3 them women, included study. The median pretreatment rating score (range, 3–4) dropped...
Balance confidence and fear of falling are factors associated with recurrent falls in people Parkinson disease (PD). However, the accuracy for predicting on basis self-report measures has not been widely investigated.The study objectives were: (1) to compare Activities-specific Confidence Scale (ABC) Falls Efficacy Scale-International (FES-I) that Berg (BBS), Dynamic Gait Index (DGI), Functional Reach Test (FRT), Timed "Up & Go" (TUG) PD (2) explore ability combinations up 3 tests predict...
Background:Predictors of falls in people with Parkinson's disease (PD) who have not previously fallen are yet to be identified. Objectives:We aimed identify predictors all and recurrent PD had the previous year explore timing a 12-month follow-up period. Methods:Participants (n = 130) were assessed by disease-specific, self-report balance measures. Falls recorded prospectively for 12 months. Univariate multivariate analyses performed. Kaplan-Meier survival analysis was used investigate time...
Recently, we have shown that the Parkinson's disease (PD) susceptibility locus MAPT (microtubule associated protein tau) is with parkinsonism in older adults without a clinical diagnosis of PD. In this study, investigated relationship between parkinsonian signs and transcripts by assessing effect haplotypes on alternative splicing expression levels most common isoforms two prospective clinicopathologic studies aging.using regression analysis, controlling for age, sex, study neuropathology,...
Freezing of gait is a disabling feature Parkinson's disease, and it has been shown that nonmotor symptoms, such as anxiety cognitive impairment, may be involved in the pathophysiology phenomenon. However, association between freezing severity symptoms yet to determined. Therefore, overall aim this study was determine factors contribute people with disease. Participants (N=78) were assessed by disease-specific self-report measures, including Hospital Anxiety Depression Scale (HADS), Montreal...
Background: Falls are a debilitating problem for people with Parkinson's disease (PD). Objectives: To compare clinical and functional characteristics of non-fallers, single recurrent fallers (≥2 falls); to determine predictors time second fall; develop predictive tool identif ying PD at different categories falls risk. Methods: Participants (n = 229) were assessed by disease-specific, self-report balance measures followed up 12 months. Area under the receiver operating characteristic curves...
Falls can be considered a disabling feature in Parkinson's disease. We aimed to identify risk factors for falling, testing simultaneously the ability of disease-specific and balance-related measures. evaluated 171 patients, collecting demographic clinical data, including standardized assessments with Unified Disease Rating Scale (UPDRS), activities daily living (ADL) motor sections, modified Hoehn Yahr Scale, Schwab England, eight-item Questionnaire, Activities-specific Balance Confidence...
ABSTRACT Objective Parkinson’s disease (PD) management is usually successfully reached with proper pharmacological treatment. However, PD patients can manifest neuropsychiatric symptoms secondary to medical therapy, including impulse control disorders (ICD), presenting as pathological gambling, hypersexuality, compulsive buying, drinking or eating disorders. We translated and validated the Portuguese version of gold-standard questionnaire Disease Impulsive-Compulsive Disorders Questionnaire,...
Falls are frequent in Parkinson's disease (PD), but there is lack of information about predictors injurious falls.To determine falls with injuries people PD; to compare circumstances and consequences single recurrent fallers.Participants (n = 225) were assessed by disease-specific, self-report, balance measures, followed-up for 12 months a diary record falls, their circumstances, injuries. Univariate multivariate analyses performed. Circumstances presented fallers compared.A total 805...
Purpose To verify the psychometric properties of Brazilian-Portuguese version Falls Behavioral (FaB-Brazil) Scale in Parkinson's disease (PD).Material and Methods Participants (n = 96) were assessed by disease-specific, self-report functional mobility measures. Internal consistency FaB-Brazil scale was evaluated using Cronbach's alpha inter-rater test–retest reliability intraclass correlation coefficients (ICC). The standard error measurement (SEM), minimal detectable change (MDC), ceiling...
To develop and cross-culturally adapt a Brazilian-Portuguese version of the Falls Behavioral Scale (FaB-Brazil) to verify its psychometric properties.The translation cross-cultural adaptation process scale followed standard guidelines. The FaB-Brazil was applied 93 community-dwelling older people. Cronbach's alpha calculated evaluate internal consistency intraclass correlation coefficient (ICC) interrater test-retest reliability. error measurement (SEM), minimal detectable change (MDC),...