A5020404735- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Ion Channels and Receptors
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Mast cells and histamine
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Electrochemical Analysis and Applications
Institute of Evolutionary Physiology and Biochemistry
2017-2022
University of Helsinki
2020-2021
Abstract Early life stress (ELS) is a well-characterized risk factor for mood and anxiety disorders. GABAergic microcircuits in the amygdala are critically implicated anxiety; however, whether their function altered after ELS not known. Here we identify novel mechanism by which kainate receptors (KARs) modulate feedforward inhibition lateral (LA) show that this downregulated induced maternal separation (MS). Specifically, control rats but MS, endogenous activity of GluK1 subunit containing...
Perturbed information processing in the amygdala has been implicated developmentally originating neuropsychiatric disorders. However, little is known on mechanisms that guide formation and refinement of intrinsic connections between amygdaloid nuclei. We demonstrate rodents glutamatergic connection from basolateral to central (BLA-CeA) develops rapidly during first 10 postnatal days, before external inputs underlying amygdala-dependent behaviors emerge. During this restricted period synaptic...
Acid-sensing ion channels (ASICs) participate in synaptic transmission due to the acidic content of vesicles, but their contribution postsynaptic currents is small. This has stimulated attempts find endogenous ASIC potentiators that could enhance ASIC-mediated physiologically relevant values. Here we demonstrate glutamate, which serves as a neurotransmitter, potentiates recombinant ASIC1a submillimolar concentration range. The effect glutamate especially interesting ASIC's presence been...
Acid-sensing ion channel 3 (ASIC3) is an important member of the acid-sensing channels family, which widely expressed in peripheral nervous system and contributes to pain sensation. ASICs are targeted by various drugs toxins. However, mechanisms structural determinants ligands’ action on ASIC3 not completely understood. In present work we studied modulation a series “hydrophobic monoamines” their guanidine analogs, were previously characterized affect other ASIC via multiple mechanisms....