A5037987786- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Musculoskeletal pain and rehabilitation
- Pharmacological Effects and Assays
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Diet and metabolism studies
- Motor Control and Adaptation
- Dermatoglyphics and Human Traits
- Tryptophan and brain disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Musicians’ Health and Performance
- Muscle activation and electromyography studies
- Child Nutrition and Water Access
- Heart Rate Variability and Autonomic Control
- Science and Education Research
- Indigenous Health and Education
University of Zurich
2023
Universidade de Itaúna
2021
Instituto Gulbenkian de Ciência
2017-2020
Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on physiological context. It is currently unknown how mediate these opposing effects. Utilizing virus-based strategies Tph2-Cre transgenic mice, we identified two anatomically separated populations of hindbrain located the lateral paragigantocellularis (LPGi) medial hindbrain, which respectively innervate superficial deep spinal dorsal horn have...
Anti-obesity drugs in the amphetamine (AMPH) class act brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any vivo evidence, is attributed a direct sympathomimetic action heart. Here, we show that cardiac side AMPH originate from can be circumvented PEGylation (PEGyAMPH) exclude its central action. PEGyAMPH does not enter facilitates SNS activity via theβ2-adrenoceptor, protecting mice against...
Corticospinal tract (CST) neurons innervate the deep spinal dorsal horn to sustain chronic neuropathic pain. The majority of targeted by CST are interneurons expressing transcription factor c-Maf. Here, we used intersectional genetics decipher function these in sensory circuits. We find that excitatory c-Maf (c-MafEX) receive input mainly from myelinated fibers and target parabrachial projection superficial neurons, thereby connecting non-nociceptive nociceptive output structures. Silencing...
Background: the aim of present study was to compare prevalence metabolic syndrome in Brazilian children aged 6-10 years using three different international criteria. Methods: systolic and diastolic blood pressure (SBP DBP), high-density lipoprotein (HDL) cholesterol, low-density (LDL) triglycerides, fasting glucose, insulin levels were measured 290 schoolchildren, presence analyzed according criteria established by Cook, Boney, Ferreira. Results: 2.27 % (Boney Ferreira criteria) 7.58 (Cook...
Objective: to verify the prevalence and factors associated with overweight body mass index (BMI) in schoolchildren. Methods: this was a cross-sectional epidemiological study which 60 children from six 10 years of age were evaluated three public schools Itauna-MG. They classified by BMI/age, their parents answered questionnaire about demographic data, medical family history, lifestyle, semi-quantitative food frequency. The data aid Excel SPSS software. Statistical tests for logistic linear...
A Síndrome Metabólica (SM) é um transtorno representado por conjunto de fatores risco cardiovasculares, relacionados à deposição central gordura e resistência insulina. Representa a combinação pelo menos três componentes cinco (hipertensão, hiperglicemia, HDL colesterol baixo, nível triglicérides elevado, circunferência abdominal) alterados, definição recomendada pela I Diretriz Brasileira Diagnóstico Tratamento da (SM). O objetivo deste trabalho foi determinar prevalência SM o Índice Massa...
Abstract Spinally-projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on physiological context. It is currently unknown how mediate these opposing effects. Utilizing virus-based strategies, we identified two anatomically separated populations of hindbrain located the lateral paragigantocellularis (LPGi) medial hindbrain, which respectively innervate superficial deep spinal dorsal horn have contrasting...