A5004226970- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Dysphagia Assessment and Management
- Cutaneous Melanoma Detection and Management
- Layered Double Hydroxides Synthesis and Applications
- Vascular Anomalies and Treatments
- Folate and B Vitamins Research
- Lung Cancer Diagnosis and Treatment
University Hospitals Birmingham NHS Foundation Trust
2008-2024
Queen Elizabeth Hospital Birmingham
2008-2023
Queen Elizabeth University Hospital
2010-2015
Queen Elizabeth Hospital Birmingham Charity
2013
NIHR Surgical Reconstruction and Microbiology Research Centre
2012
University Hospital of Wales
2005
Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor clinical outlook. Responses to immune checkpoint blockade are suboptimal and much more detailed understanding of the tumor microenvironment is needed if this situation be improved. Here, we characterized tumor-infiltrating T-cell populations in patients with PDAC using cytometry by time flight (CyTOF) single-cell RNA sequencing. T cells were predominant cell subset observed within tumors. Over 30% CD4+ expressed CCR6+CD161+ Th17...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common tumor subtypes and remains associated with very poor survival. T cell infiltration into tissue improved clinical outcome but little known regarding potential role NK cells in disease control. Here we analyze phenotype function blood from patients PDAC. Peripheral are present normal numbers display a CD16hiCD57hi marked downregulation NKG2D. Importantly, these demonstrate reduced cytotoxic activity low levels IFN-γ expression...
Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts dominant but heterogenous population within the tumor microenvironment therapeutic targeting of stromal subsets may have utility. Here, we combine spatial transcriptomics scRNA-Seq datasets define transcriptome tumor-proximal tumor-distal cancer-associated (CAFs) link this outcome. Tumor-proximal comprise large populations myofibroblasts, strongly expressed...
<b>Background and study aim:</b> Mucosal neoplasia arising in Barrett's esophagus can be successfully treated with endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA). The aim of the was to compare clinical outcomes patients high grade dysplasia (HGD) or intramucosal cancer (IMC) at baseline from United Kingdom RFA registry. <b>Patients methods:</b> Prior RFA, visible lesions nodularity were removed entirely EMR. Thereafter, underwent every 3 months until all mucosa...
Background and aim: Endoscopic ultrasound-guided drainage is a minimally invasive first-line modality for the of pancreatic fluid collection (PFC) resulting in shorter hospital stay less morbidity compared with surgical cystogastrostomy. Our aim to evaluate potential differences outcomes endoscopic ultrasound (EUS) guided transmural (EUS-TD) pseudocyst (PP) walled-off necrosis (WON).Method: We retrospectively reviewed 100 consecutive EUS-guided drainages PFC utilising EUS reports; clinical...
Bleeding from parastomal varices causes significant morbidity and mortality. Treatment options are limited, particularly in high-risk patients with underlying liver disease other comorbidities. The use of EUS-guided embolisation coils combined thrombin injection gastric has been shown to be safe effective. Our institution applied the same technique treatment varices.A retrospective review was performed 37 procedures on 24 assess efficacy safety thrombin, or without for bleeding varices. All...
An endoscopic ultrasound scan is a common procedure used to diagnose conditions of the upper gastrointestinal tract. We present case hypopharyngeal perforation complicating treated with primary surgical repair.A 62-year-old woman underwent an for investigation pancreatic lesion. A high esophageal occurred during procedure. She emergency repair this via external approach. Unfortunately her recovery was complicated by pleural effusion which required chest drain. made complete recovery,...
Abstract Background Gastrointestinal stromal tumours (GIST) frequently occur in patients with neurofibromatosis type 1 (NF-1). It has been reported that GIST may co-exist pancreatic endocrine tumors but this only association NF-1. Case presentation A 76 year old woman presented a 12 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated 13 mm insulinoma localized the tail her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation when small...
Acute spontaneous compartment syndrome is a rare orthopaedic emergency that usually presents to general physicians as an acute medical admission. Most cases reported date, in patients with diabetes, are those long-standing disease or evidence of diabetic complications. An girl recent diagnosis type 1 diabetes here. Awareness the condition allows early recognition and diagnosis, thereby preventing more severe muscle necrosis disability.
<h3>Introduction</h3> Gastric varices are present in 5%–33% of patients with portal hypertension incidence bleeding around 25% 2 years.<sup>1</sup> If gastric identified as the source bleeding, therapeutic options include endoscopic Methods, TIPSS, surgery and non-selective beta blockade.<sup>2</sup> There reports EUS guided coiling combined cyanoacrylate glue<sup>3</sup> but limited literature on safety efficacy coil embolisation human thrombin injection. We report our experience....