A5080356805- CAR-T cell therapy research
- Multiculturalism, Politics, Migration, Gender
- Monoclonal and Polyclonal Antibodies Research
- Migration, Identity, and Health
- Photosynthetic Processes and Mechanisms
- Immune Cell Function and Interaction
- Healthcare Systems and Practices
- T-cell and B-cell Immunology
- Photoreceptor and optogenetics research
- French Urban and Social Studies
- Hematopoietic Stem Cell Transplantation
- Hormonal Regulation and Hypertension
- Urological Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- Aging, Elder Care, and Social Issues
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Renal and Vascular Pathologies
- Histone Deacetylase Inhibitors Research
- Parkinson's Disease Mechanisms and Treatments
- Spectroscopy and Quantum Chemical Studies
Klinikum Leverkusen
2022-2024
University of Birmingham
2024
Starnberg Hospital
2023
University of Cologne
2020-2022
Centre National de la Recherche Scientifique
1997-2022
Délégation Centre-Est
2016-2022
Université de Versailles Saint-Quentin-en-Yvelines
2022
Johannes Gutenberg University Mainz
2017-2021
University Hospital Cologne
2020-2021
Helios Kliniken
2020-2021
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of proinflammatory cytokine interleukin-1β implicated in many inflammatory diseases. Here we show that several clinically approved widely used NSAIDs fenamate class are effective selective inhibitors via inhibition volume-regulated anion channel macrophages, independently COX Flufenamic acid mefenamic...
Recent reports have challenged the notion that retroviruses and retroviral vectors integrate randomly into host genome. These pointed to a strong bias toward integration in near gene coding regions and, for gammaretroviral vectors, around transcription start sites. Here, we report results obtained from large-scale mapping of 572 sites (RISs) isolated cells 9 patients with X-linked SCID (SCID-X1) treated retrovirus-based therapy protocol. Our data showed two-thirds insertions occurred or very...
The chemokine CCL5 plays a critical role as neutrophil and macrophage activator do in atherosclerosis myocardial infarction. Thus, we investigated whether the treatment with neutralizing monoclonal antibody (mAb) to mouse would provide therapeutic benefit when provoking coronary-associated ischaemic event.C57Bl/6 mice were submitted left coronary artery permanent ligature. Then, various parameters monitored for up 21 days. At5 min 3 days after occlusion, received one intravenous injection of...
Abstract A key pathological process in Parkinson's disease (PD) is the transneuronal spreading of α‐synuclein. Alpha‐synuclein (α‐syn) a presynaptic protein that, PD, forms inclusions. Other hallmarks PD include neurodegeneration and microgliosis susceptible brain regions. Whether it primarily α‐syn particles, inclusion formation, or other mechanisms, such as inflammation, that cause unclear. We used model induced by striatal injection preformed fibrils into mouse striatum to address this...
In cirrhosis, splanchnic vasodilation contributes to portal hypertension, subsequent renal sodium retention, and formation of ascites. Urotensin II(U-II) is a constrictor large conductive vessels. Conversely, it relaxes mesenteric vessels, decreases glomerular filtration, increases retention. patients with U-II plasma levels are increased. Thus, we investigated hemodynamic effects its receptor antagonist, palosuran, in cirrhotic bile duct-ligated rats (BDL). BDL sham-operated rats, studied...
This study aimed to compare the diagnostic performance of [18F]PSMA-1007 positron emission tomography/computed tomography (PET/CT) (18F-PSMA) and [68Ga]Ga-PSMA-11 PET/CT (68Ga-PSMA) by identifying prostate-specific antigen (PSA) threshold levels for optimal detecting recurrent prostate cancer (PC) both methods. Retrospectively, included 264 patients. The performances 18F-PSMA 68Ga-PSMA in relation pre-scan PSA were assessed receiver operating characteristic (ROC) curve. showed PC-lesions...
The terminal part of the electron pathway within photosystem I (PSI) complex includes two [4Fe-4S] centers, FA and FB, which are coordinated by PsaC subunit. To gain new insights into transfer mechanisms through PsaC, we have generated three mutant strains alga Chlamydomonas reinhardtii in positively charged residues, K52 R53, near center been altered different ways. mutations K52S/R53D K52P/R53D lead to a strong destabilization PSI. third K52S/R53A accumulates PSI 30% wild-type levels...
Atelectasis because of anesthesia is a recognized problem but may be affected by the anesthetic technique. We compared magnetic resonance images atelectasis in children undergoing two types anesthesia.Children requiring for imaging (MRI) had additional lung sequences at beginning and end anesthesia. Children either i.v. propofol infusion (PI) without an artificial airway (n = 26) or positive pressure ventilation (PPV) via tracheal tube 20); technique was chosen clinical reasons. The extent...
Virtual reality exposure therapy (VRET) has been shown to be as effective traditional forms of in vivo for the treatment specific phobias. However, with exposure, VRET still involves relatively high costs and limited accessibility which makes it prohibitive a large part population. Innovative methods using smartphone applications (apps) may improve scalability VRET. The aim this study is evaluate 0Phobia, gamified self-guided acrophobia that delivered through app combination rudimentary...
Routine [68Ga]Ga-PSMA-11 PET/CT (one hour post-injection) has been shown to accurately detect prostate cancer (PCa) lesions. The goal of this study is evaluate the benefit a dual-time point imaging modality for staging and restaging PCa patients. Biphasic 233 patients, who underwent early late scans (one/three hours post-injection), were retrospectively studied. Tumor uptake biphasic lesion detection 215 biochemically recurrent patients previously treated localized (prostatectomized...
In order to contain the coronavirus disease 2019 (COVID-19) pandemic, Germany has implemented drastic restrictions on public or social life, while health institutions are invoked postpone elective procedures. Although urologists less involved in direct treatment of COVID-19 patients, current situation strongly affects urological work routine.
Hybrid imaging with prostate-specific membrane antigen (PSMA) is gaining importance as an increasingly meaningful tool for prostate cancer (PC) diagnostics and a guide therapy decisions. This study aims to investigate compare the performance of [18F]PSMA-1007 (18F-PSMA) [68Ga]Ga-PSMA-11 positron emission tomography/computed tomography (68Ga-PSMA) in initial staging PC patients.The data 88 biopsy-proven patients were retrospectively evaluated. PSMA-avid lesions compared histopathologic...
The two [4Fe-4S] clusters F<sub>A</sub>and F<sub>B</sub> are the terminal electron acceptors of photosystem I (PSI) that bound by stromal subunit PsaC. Soluble ferredoxin (Fd) binds to PSI via electrostatic interactions and is reduced outermost iron-sulfur cluster We have generated six site-directed mutants green alga <i>Chlamydomonas reinhardtii</i> in which residues located close PsaC changed. acidic Asp<sup>9</sup> Glu<sup>46</sup>, one residue upstream first cysteine liganding...
68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC) in European clinical practice. The goal of this study to determine the optimum time performing these PET/CT scans a large cohort patients by identifying prostate-specific-antigen (PSA) and PSA kinetics thresholds detecting localizing PC. This retrospective analysis includes 581 with biochemical recurrence (BC) definition. performance relation value at scan as...
PsaJ is a small hydrophobic subunit of the photosystem I complex (PSI) whose function not yet fully understood. Here we describe mutants green alga Chlamydomonas reinhardtii, in which psaJ chloroplast gene has been inactivated either wild-type or PsaF-deficient nuclear background. Cells lacking one both subunits grow photoautotrophically and contain normal levels PSI. Flash-absorption spectroscopy performed with isolated PSI particles from PsaJ-deficient strain indicates that only 30%...
Atherosclerosis, caused in part by monocytes plaques, continues to be a disease that afflicts the modern world. Whilst significant steps have been made treating this chronic inflammatory disease, questions remain on how prevent monocyte and macrophage accumulation atherosclerotic plaques. Junctional Adhesion Molecule C (JAM-C) expressed vascular endothelium directs transendothelial migration unidirectional manner leading increased inflammation. Here we show interfering with JAM-C allows...