A5089709417- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Heart Failure Treatment and Management
- BRCA gene mutations in cancer
- Cardiac electrophysiology and arrhythmias
- Statistical Methods in Clinical Trials
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Biomedical Text Mining and Ontologies
- Cardiovascular Function and Risk Factors
- Genomics and Rare Diseases
- Fungal Infections and Studies
- Pharmacology and Obesity Treatment
- Innovations in Medical Education
- Peroxisome Proliferator-Activated Receptors
- Potassium and Related Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
Research & Development Institute
2020-2023
University of Florida
2014-2021
Florida College
2014-2020
University of Illinois Chicago
2015
Therapeutic concentrations of voriconazole in invasive fungal infections (IFIs) are ensured using a drug monitoring approach, which relies on attainment steady‐state pharmacokinetics. For voriconazole, time to reach steady state can vary from 5–7 days, not optimal for critically ill patients. We developed population pharmacokinetic/pharmacodynamic model‐based approach predict doses that maximize the net benefit (probability efficacy‐probability adverse events) and ensure therapeutic...
Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical decisions. This article describes the development of an outpatient, pharmacist-led, pharmacogenetics consult clinic within internal medicine, its workflow, and early results, along with successes challenges. A pharmacogenetics-trained pharmacist encouraged primary care physicians (PCPs) refer patients who were experiencing side effects/ineffectiveness from certain antidepressants, opioids, and/or proton pump...
There have been significant advancements in precision medicine and approaches to medication selection based on pharmacogenetic results. With the availability of direct‐to‐consumer genetic testing growing awareness interindividual variability, patient demand for more precise, individually tailored drug regimens is increasing. The University Florida (UF) Health Precision Medicine Program (PMP) was established 2011 improve integration genomic data into clinical practice. In ensuing years, UF...
Pharmacogenetic testing can help identify primary care patients at increased risk for medication toxicity, poor response or treatment failure and inform drug therapy. While availability is increasing, providers are unprepared to routinely use pharmacogenetic clinical decision-making. Practice-based resources needed overcome implementation barriers in care.The NHGRI's IGNITE I Network (Implementing GeNomics In pracTicE; www.ignite-genomics.org) explored practice models, challenges...
Abstract Heart failure with preserved ejection fraction (HFpEF) patients who develop pulmonary hypertension (PH) have an increased risk of death, combined pre- and post-capillary PH (CpcPH) having the highest risk. However, mechanism behind development in HFpEF is poorly understood. We aimed to identify transcriptomic associations HFpEF. Blood was collected from 30 patients: 10 without PH, isolated CpcPH. Gene expression measurements were completed using transcriptome-wide RNA sequencing....
Clinical adoption of genomic medicine has lagged behind the pace scientific discovery. Practice-based resources can help overcome implementation challenges.In 2015, IGNITE (Implementing GeNomics In pracTicE) Network created an online resource toolbox that was expanded in 2017 to incorporate ability for users create targeted guides. This expansion led by a multidisciplinary team developed evidence-based, structured framework guides, oversaw technical process/build, and pilot tested first...
Thiazide diuretics have been associated with increased risk for new onset diabetes (NOD), but pharmacogenetic markers of thiazide-induced NOD are not well studied. Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent strongest and most reproducible genetic associations diabetes. We investigated association tag SNPs TCF7L2 NOD.We identified cases that developed age, sex, race/ethnicity-matched controls from INternational VErapamil SR-Trandolapril...
The biological mechanisms behind the development of pulmonary hypertension in setting left heart failure (HF‐PH), including combined pre‐ and post‐capillary (Cpc‐PH), remains unclear. This study aimed to use candidate polymorphisms nitric oxide synthase (NOS) genes explore role NOS HF‐PH. DNA samples from 118 patients with HF‐PH were genotyped for NOS3 rs1799983 NOS2 rs3730017 polymorphisms. A multiple regression model was used compare hemodynamic measurements between genotype groups....
(1) Background: Clinical decision support (CDS) is a vitally important adjunct to the implementation of pharmacogenomic-guided prescribing in clinical practice. A novel CDS was sought for APOL1, NAT2, and YEATS4 genes guide optimal selection antihypertensive medications among African American population cared at multiple participating institutions trial. (2) Methods: The committee, made up content experts, developed framework contributed creation using following guiding principles: 1....
ABSTRACT The risk-benefit ratio associated with the use of repurposed drugs to treat 2019 SARS-CoV-2 related infectious disease (COVID-19) is complicated since benefits are awaited, not proven. A thorough literature search was conducted source information on pharmacological properties 5 and 1 combination (azithromycin, chloroquine, favipiravir, hydroxychloroquine, remdesivir, lopinavir/ritonavir) COVID-19. risk assessment drug-induced Long QT Syndrome (LQTS) COVID-19 performed compared 23...
We compared patient cohorts selected for pharmacogenomic testing using a manual method or automated algorithm in university-based health insurance network. The medication list was compiled from claims data during 4th quarter 2018. patients by number of medications the system's testing. used YouScript's pharmacogenetic interaction probability (PIP) to select based on that would result detection one more clinically significant interactions. A total 6916 were included. Patient each differed...
The IGNITE network funds six genomic medicine projects. Though interventions varied, we hypothesized that synergies across projects could be leveraged to better understand the participant experiences with interventions. Therefore, performed cross-network analyses identify associations between demographics and attitudes toward intervention (attitude), plan share results (share), quality of life (QOL). Data collection for demographics, attitude, share, QOL surveys were standardized Recruitment...
Heart failure (HF) is highly prevalent and a major cause of death in the United States. The effect HF medications on survival has been predicted by validated models studied populations predominantly European descent. This study aimed to identify associated with racially diverse population. Patients were recruited followed from 2001 2015. Data collected electronic health records Social Security Death Index. primary analysis tested association between medication dose all-cause mortality,...
Abstract Introduction Although the majority of pharmacy schools are teaching pharmacogenetics in their curricula, there is limited coverage important clinical concepts and pharmacists report low comfortability utilizing pharmacogenetic results. Objectives To compare effectiveness a combined didactic patient case‐based, interactive approach (including optional personal genotyping) with traditional strategy on students' knowledge confidence ability to use data decision‐making. Methods The...
Abstract Introduction Clinical pharmacogenomics is a required element in the Doctor of Pharmacy (Pharm.D.) curriculum. However, not widely adopted into clinical practice and as such, considerable variability teaching learning activities within pharmacogenomic advanced pharmacy experiences (APPE) exist. Among other places University Florida's Pharm.D. curriculum, practical applications are covered during APPE year through an elective 6‐week Pharmacogenomics APPE. Objectives Describe our...
OBJECTIVES/SPECIFIC AIMS: Compare effectiveness of a patient case-based, interactive teaching approach that included optional student genotyping with traditional didactic strategies for increasing students’ knowledge and ability to effectively use pharmacogenomic data in clinical decision making. METHODS/STUDY POPULATION: The UF College Pharmacy offers required Personalized Medicine (PM) course pharmacy students as well an elective course, Clinical Applications (CAPM). Students dual enrolled...
Introduction: While African Americans (AAs) have the highest prevalence of heart failure (HF) and HF mortality, insufficient data exists regarding impact medication on mortality in AAs. This study aimed to identify use practices associated with survival a predominantly AA population. Methods: patients were prospectively recruited from, followed within, University Illinois Health System from 11/2001 11/2015, when vital status was determined. Data extracted electronic health records Social...