A5101837756- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Virus-based gene therapy research
- Global Financial Crisis and Policies
- Heart Failure Treatment and Management
- Mitochondrial Function and Pathology
- Hemoglobin structure and function
- Skin Protection and Aging
- Banking stability, regulation, efficiency
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Photosynthetic Processes and Mechanisms
- High Altitude and Hypoxia
- Cancer-related gene regulation
- CAR-T cell therapy research
- Pluripotent Stem Cells Research
- RNA regulation and disease
- Histone Deacetylase Inhibitors Research
- Viral Infectious Diseases and Gene Expression in Insects
- melanin and skin pigmentation
- Molecular Biology Techniques and Applications
- Neuroscience and Neural Engineering
- Epigenetics and DNA Methylation
University of Pennsylvania
2017-2024
Massachusetts General Hospital
2015-2016
Beth Israel Deaconess Medical Center
2012-2016
University of Southern California
2012-2013
Doheny Eye Institute
2012
University of California, Los Angeles
2008
University of Colorado Boulder
2008
Ono Pharmaceutical (United States)
2007
Summary We use LASSO methods to shrink, select, and estimate the high‐dimensional network linking publicly traded subset of world's top 150 banks, 2003–2014. characterize static connectedness using full‐sample estimation dynamic rolling‐window estimation. Statically, we find that global bank equity has a strong geographic component, whereas country sovereign bond does not. Dynamically, increases during crises, with clear peaks Great Financial Crisis each wave subsequent European Debt Crisis,...
<b><i>Objective:</i></b> To evaluate the feasibility of a new technique for implantation ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into subretinal space retina-degenerate Royal College Surgeon (RCS) rats. <b><i>Methods:</i></b> A platform device was used 4-µm-thick parylene monolayer human embryonic RPE (hESC-RPE). Normal Copenhagen rats (n = 6) and RCS 5) were study. Spectral-domain optical...
Recently, it has been reported that mitochondria possess a novel pathway for nitric oxide (NO) synthesis. This is induced when cells experience hypoxia, nitrite (NO(2)(-))-dependent, independent of NO synthases, and catalyzed by cytochrome c oxidase (Cco). It proposed this mitochondrially produced component hypoxic signaling the induction nuclear genes. In study, we examine NO(2)(-)-dependent production in yeast engineered to contain alternative isoforms, Va or Vb, Cco subunit V. Previous...
Duchenne muscle dystrophy (DMD) is one of the most common lethal genetic diseases children worldwide and 100% fatal. Steroids, only therapy currently available, are marred by poor efficacy a high side-effect profile. New therapeutic approaches urgently needed. Here, we leverage PGC-1α, powerful transcriptional coactivator known to protect against in mdx murine model DMD, search for novel mechanisms protection dystrophy. We identify heme oxygenase-1 (HO-1) as potential target treatment DMD....
Chinese hamster ovary (CHO) cells are conventionally used to generate therapeutic cell lines via random integration (RI), where desired transgenes stably integrated into the genome. Targeted (TI) approaches, which involve of a transgene specific locus in genome, increasingly utilized for CHO line development (CLD) recent years. None these CLD however, suitable expression toxic or difficult‐to‐express molecules, determining underlying causes poor some molecules. Here we introduce regulated...
Fundamental changes in nutrient metabolism underlie many disease processes, including obesity, diabetes, and cancer. Metabolic derangements are also a hallmark of heart disease, both the context failure ischemia, likely contributors to its etiology. For example, while healthy favors fats as fuel, failing hearts will consume more glucose; but it is unclear if this pathological or protective. It very that manipulation metabolic pathways can affect, possibly augment protect, function. Yet no...
Recent advances in mass spectrometry have led to in-depth characterization of both tissue and cellular acetylation profiles (or “acetylomes”). These studies reveal the abundance importance this post-translational modification not only transcriptional control, but also many signaling metabolic pathways. In heart, has been found play a role cardiac proliferation, differentiation, hypertrophy developmental pathological settings. To examine exercise-induced hypertrophy, we studied expression...