A5060317018- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Skin and Cellular Biology Research
- Central Venous Catheters and Hemodialysis
- Vascular Malformations and Hemangiomas
- Complementary and Alternative Medicine Studies
- Hidradenitis Suppurativa and Treatments
- Anorectal Disease Treatments and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Dupuytren's Contracture and Treatments
- RNA and protein synthesis mechanisms
- Transgenic Plants and Applications
- DNA Repair Mechanisms
- Infectious Diseases and Mycology
- Adrenal Hormones and Disorders
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- Exercise and Physiological Responses
- Medicine and Dermatology Studies History
- Teratomas and Epidermoid Cysts
- Ion channel regulation and function
- Polysaccharides and Plant Cell Walls
- Food Allergy and Anaphylaxis Research
Leiden University Medical Center
2025
Erasmus MC
2020-2024
Erasmus University Rotterdam
2021-2024
Erasmus MC - Sophia Children’s Hospital
2022-2024
Loyola University Medical Center
2024
Abstract Background The Recap of atopic eczema questionnaire (RECAP) was developed to measure control in patients with dermatitis (AD). measurement properties RECAP have not yet been validated caregivers children AD. Objectives To assess the construct validity, responsiveness, reliability and interpretability Dutch proxy version RECAP. Methods A prospective validation study conducted (aged < 12 years) AD their (in a tertiary hospital). At three timepoints (T0 = baseline; T1 after 1–7...
Netherton syndrome (NS) is a rare potential life-threatening disorder that causes severe defects to the skin barrier. No effective treatment options are available for patients with NS and current therapy mostly supportive. The effects of intravenous immunoglobulins (IVIGs), ixekizumab, dupilumab have scarcely been reported. Additionally, role anakinra in has never investigated.The objective was report our experiences IVIG, dupi-lumab, NS.A retrospective case series, including 5 NS, performed...
The Atopic Dermatitis Control Tool (ADCT) has not been validated in the Dutch population, and comparisons with Recap of atopic eczema (RECAP) questionnaire are still lacking. This prospective study was conducted at a tertiary hospital between June 2021 December 2022, to assess measurement properties ADCT adults dermatitis (AD) compare it RECAP. Participants completed ADCT, RECAP, reference instruments including Patient’s Global Assessment (PtGA), Patient-Oriented Eczema Measure (POEM),...
DNA double-strand breaks (DSBs) are highly toxic lesions that can lead to chromosomal instability, loss of genes and cancer. The MRE11/RAD50/NBN (MRN) complex is keystone involved in signaling processes inducing the repair DSB by, for example, activating pathways leading homologous recombination nonhomologous end joining. Additionally, MRN also plays an important role maintenance telomeres act as a stabilizer at replication forks. Mutations NBN MRE11 associated with Nijmegen breakage...
Limited research has been conducted on the measurement properties of Recap atopic eczema (RECAP) questionnaire, particularly in relation to interpretability.To investigate validity, reliability, responsiveness and interpretability Dutch RECAP adults with dermatitis (AD).We a prospective study tertiary hospital, recruiting AD between June 2021 December 2022. Patients completed reference instruments anchor questions at following three timepoints: baseline, after 1-3 days 4-12 weeks. Hypotheses...
The first wave of the coronavirus disease 2019 (COVID-19) pandemic had an enormous impact on health-care services, including care provision for children with atopic dermatitis (AD). We investigated COVID-19 moderate to severe AD at our tertiary outpatient clinic and examined satisfaction care. reviewed records, comparing total number types consultations during (March until July 2020) corresponding months 2018. In addition, we conducted a questionnaire-based study investigating clinical...
Reliable assessment of atopic dermatitis (AD) severity is necessary for clinical practice and research. Valid reliable remote essential to facilitate care research.Assess the validity reliability Eczema Area Severity Index (EASI) based on images patient-assessed Self-Administered EASI (SA-EASI).Whole-body were taken during consultation from children with AD. After consultations, caregivers completed SA-EASI provided home. Four raters assessed all twice using EASI.A total 1534 425...
Background Pathogenic germline variants in T ransient R eceptor P otential V anilloid 4 C ation hannel ( TRPV4 ) lead to channelopathies, which are phenotypically diverse and heterogeneous disorders grossly divided neuromuscular skeletal dysplasia. We recently reported sporadic giant cell lesions of the jaws (GCLJs) novel, somatic, heterozygous, gain-of-function mutations , at Met713. Methods Here we report two unrelated women with a de novo p.Leu619Pro variant an overlapping systemic...
Recap of atopic eczema (RECAP) is a patient-reported outcome measure assessing control. This instrument has been developed and validated in the UK. There are self-reported proxy-reported versions English, Dutch German. However, it unclear whether version shows adequate content validity when completed by young people (8-16 years) these languages.To assess (comprehensibility, relevance comprehensiveness) German RECAP with to identify most appropriate age cutoff for self-completion.We conducted...
General practitioners (GPs) have an important role in managing patients with atopic dermatitis (AD). Although pivotal, adherence to dermatological guidelines general practice has not been assessed.To assess GPs' perceived and barriers the Dutch AD guideline.A survey was conducted among 391 GPs Netherlands between December 2021 May 2022. rated their concerning five key recommendations of guideline, following existing framework. The correlation investigated using Spearman's rank correlation.A...
Background: After excision surgery in patients with hidradenitis suppurativa (HS), wounds are usually left open for secondary intention healing. To evaluate wound healing, reliable measurement is important. However, digital tools measuring the surface area validated small located on flat or mildly convex body surfaces studies, often powered inadequately. Up until now, a tool to accurately measure all surfaces, including intertriginous areas, was not available. Objectives: The aim of this...
Abstract Background Increased Staphylococcus aureus (SA) colonization is considered an important factor in the pathogenesis of atopic dermatitis (AD). Antibacterial therapeutic clothing aims to reduce SA and AD inflammation; however, its role management remains poorly understood. Objectives To investigate effectiveness antibacterial + standard topical treatment patients with moderate-to-severe vs. treatment; and, if was demonstrated, demonstrate cost-effectiveness. Methods A pragmatic...
Topical corticosteroids (TCS) are the cornerstone of treatment for patients with atopic dermatitis (AD). Unfortunately, anxiety and misplaced beliefs on TCS, known as corticophobia, is common among health care professionals (HCPs) could influence their practices, resulting in suboptimal patient care.
Abstract Background Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10 to 20% of children and between 2 15% the adults in Western Europe. Since 2000, therapeutic clothing or functional textiles based on silver chitosan as antibacterial agents were introduced for AD. These aim reduce colonization with Staphylococcus ( S .) aureus . Increased S. correlated increased AD severity. The antimicrobial effects have been demonstrated before. At this point, there...
Infantile haemangiomas are common benign tumours of infancy, which can be treated effectively with beta-blockers such as propranolol and atenolol. Different types may result in different long-term aesthetic outcomes. This study evaluated the difference outcomes between infantile either or atenolol, including perspective physicians, parents, children. Children, aged ≥6 years, atenolol for haemangioma during participated this 2-centre cross-sectional study. The primary endpoint was change...
Secondary infections with Staphylococcus aureus (i.e. impetiginization) are common in patients atopic dermatitis (AD). However, a scale to assess the severity of impetiginization is lacking. This study aimed develop and investigate an Investigator Global Assessment (IGA) for AD (‘IGA impetiginization’). Consensus was achieved 3-point IGA containing description clinical signs extent affected area. Substantial inter-rater reliability [intraclass correlation coefficient (ICC) 0.68], good...
National prescription data for therapeutic clothing in atopic dermatitis was analysed to investigate the role of dermatitis. Therapeutic is most frequently prescribed by dermatologists a hospital setting. Most patients only receive one clothing, suggesting limited long-term management
Introduction Children with atopic dermatitis (AD) are more at risk for the neurodevelopmental disorders attention-deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD) parallel increases in global prevalences. afflicted these conditions appear to share similar problems sensory modulation but investigational studies on underlying aetiology scarce. This scoping review aims find knowledge gaps, collate hypotheses summarise available evidence shared pathophysiology of AD, ADHD ASD...
Netherton syndrome (NS; OMIM#256500) is a rare and severe disorder of epidermal maturation keratinization caused by pathogenic variants in the serine protease inhibitor Kazal type 5 (SPINK5), leading to skin barrier impairment. Although effective treatment crucial for NS patients, there lack knowledge on what best options are these patients. Large heterogeneity reported outcomes measurement instruments hinders accurate comparison results across studies development guideline. Therefore, we...
Background: Many healthcare professionals (HCPs) deliver care for patients with atopic dermatitis (AD). Although pivotal, management strategies and the relation corticophobia among HCPs have not been investigated. This study aimed to investigate AD its HCPs. Methods: Dutch general practitioners (GPs), youth physicians (YHPs), pediatricians, dermatologists, pharmacists, pharmacy assistants participated in a survey on corticophobia. The Topical Corticosteroid Phobia questionnaire (TOPICOP-P)...
Parents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed influence on outcome characteristics haemangioma, beta-blocker treatment, and infant. The included 103 children aged 6-12 years, (propranolol or atenolol) during infancy (age at treatment initiation ≤1 year) ≥6 months. Dermatologists parents scored Patient Observer Scar Assessment Scale, child a visual analogue scale....