A5004105586- Cardiac Ischemia and Reperfusion
- Galectins and Cancer Biology
- Mitochondrial Function and Pathology
- Organ Transplantation Techniques and Outcomes
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Chronic Kidney Disease and Diabetes
- Cancer Immunotherapy and Biomarkers
- Dialysis and Renal Disease Management
- Connexins and lens biology
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- Graphene and Nanomaterials Applications
- Macrophage Migration Inhibitory Factor
- Pancreatic and Hepatic Oncology Research
- Biochemical effects in animals
- Advanced Drug Delivery Systems
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- Ion Channels and Receptors
National Taiwan University Hospital
2022-2024
National Taiwan University
2012-2019
A recent study showed that the injection of mitochondria isolated from a nonischemic region mitigated myocardial injury. We tested protective effects infusing on reperfusion injury in liver rats. partial ischemia-reperfusion (I/R) model male Wistar rats was used. At 45th minute ischemia, recipient’s spleen infused with vehicle (I/R-vehicle group) or containing (7.7 × 106 ± 1.5 106/mL, I/R-mito group). After 240-min reperfusion, serum and livers were collected to assess tissue Our results...
A new core–shell nanostructure consisting of inorganic hydroxyapatite (HAP) nanoparticles as the core and organic alginate shell (denoted HAP@Alg) was successfully synthesized by a pre-gel method applied to pH-responsive drug delivery systems (DDS). HAP@Alg have advantages alginate, where provides degradability, excellent biocompatibility COOH functionality. Through subsequent addition CaCl2 phosphate solutions solution, with controllable particle sizes (ranging from 160 650 nm) were...
As a part of natural disease progression, acute kidney injury (AKI) can develop into chronic via renal fibrosis and inflammation. LTBP4 (latent transforming growth factor beta binding protein 4) regulates beta, which plays role in pathogenesis. We previously investigated the disease. Here, we examined AKI.LTBP4 expression was evaluated human tissues, obtained from healthy individuals patients with AKI, using immunohistochemistry. knocked down both C57BL/6 mice proximal tubular cell line...
Peritoneal fibrosis remains a problem in kidney failure patients treated with peritoneal dialysis. Severe encapsulation or encapsulating sclerosis is devastating and life-threatening. Although submesothelial fibroblasts as the major precursor of scar-producing myofibroblasts animal models M2 macrophage (Mϕ)-derived chemokines effluents before diagnosis have been identified, attenuation an unmet medical need partly because mechanism for cross talk between Mϕs unclear. We use sodium...
// Shin-Yun Liu 1 , Chia-Tung Shun 2 Kuan-Yu Hung 3 Hsueh-Fen Juan 5 Chia-Lang Hsu Min-Chuan Huang 1, 6 I-Rue Lai 4 Graduate Institute of Anatomy and Cell Biology College Medicine, National Taiwan University, Taipei, Department Pathology, University Hospital, Internal Hospital Hsin-Chu Branch, Surgery, Life Science Molecular Cellular Biology, Research Center for Developmental Regenerative Correspondence to: Huang, e-mail: mchuang@ntu.edu.tw Lai, iruelai@gmail.com Keywords: gastric cancer,...
Ischemic postconditioning (iPoC) is known to mitigate ischemia-reperfusion (IR) injury of the liver, mechanisms which remain be elucidated. This study explored role microRNA-183 (miR-183) in protective mechanism iPoC.Microarray analysis showed miR-183 was robustly expressed rats' livers with iPoC. repressed mRNA expression Apaf-1, an apoptosis promoting factor. Using oxygen-glucose deprivation (OGD) model Clone 9 cells, hypoxic (HPoC) and mimetic significantly decreased cell death after OGD,...
Postconditioning mitigates ischemia‐induced cellular damage via a modified reperfusion procedure. Mitochondrial permeability transition (MPT) is an important pathophysiological change in injury. This study explores the role of MPT modulation underlying hypoxic postconditioning (HPoC) PC12 cells and studies neuroprotective effects ischemic (IPoC) on rats. Oxygen‐glucose deprivation (OGD) was performed for 10 hr cells. HPoC induced by three cycles 10‐min reoxygenation/10‐min rehypoxia after...
Immune checkpoint inhibitors are effective to treat hepatocellular carcinoma (HCC) yet only successful in a small part of patients. This study aimed investigate whether poly-ICLC, an immune stimulant, can enhance the antitumor effects anti-PD-1 on mouse HCC.
Pannexin 1 (PANX1) forms cell-surface channels capable of releasing signaling metabolites for diverse patho-physiological processes. While inhibiting dysregulated PANX1 has been proposed as a therapeutic strategy many pathological conditions, including inflammatory bowel disease (IBD), low efficacy, or poor specificity classical inhibitors introduces uncertainty their applications in basic and translational research. Here, hit-to-lead optimization is performed naphthyridone, compound 12,...
Peritoneal lavage after cancer surgery is performed to reduce microscopic residual tumors in the peritoneum. This study evaluated effects and mechanism of dialysate reducing peritoneal implantation gastric cells.Gastric cells (MKN45 or AGS) were cultured with 1.5% (PD) normal saline (NS) for 30 min. The vitro cell susceptibility dialysate, including proliferation, death, cleaved PARP expression, mitochondrial membrane potential, was evaluated. A murine model seeding established test PD NS on...