A5015852910- Nanomaterials for catalytic reactions
- Bioinformatics and Genomic Networks
- Adsorption and biosorption for pollutant removal
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- Stroke Rehabilitation and Recovery
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Virology and Viral Diseases
- Extracellular vesicles in disease
- Membrane-based Ion Separation Techniques
- biodegradable polymer synthesis and properties
- Genomics and Phylogenetic Studies
- Chemical Synthesis and Characterization
- Lipid metabolism and disorders
- Herpesvirus Infections and Treatments
- Computational Drug Discovery Methods
- Polymer composites and self-healing
- Pancreatitis Pathology and Treatment
- Advanced Drug Delivery Systems
- Transcranial Magnetic Stimulation Studies
- Immunotherapy and Immune Responses
Taipei Medical University
2014-2025
Taipei Medical University-Shuang Ho Hospital
2012-2025
University of Vermont
2023
National Taiwan University
2012-2021
National Taiwan University of Science and Technology
2017-2019
Tunghai University
2015
Taichung Armed Forces General Hospital
2013
Academia Sinica
2011
National Chung Hsing University
2002-2009
Industrial Technology Research Institute
2008
Single nucleotide polymorphism (SNP) prioritization based on the phenotypic risk is essential for association studies. Assessment of requires access to a variety heterogeneous biological databases and analytical tools. FASTSNP (function analysis selection tool single polymorphisms) web server that allows users efficiently identify prioritize high-risk SNPs according their risks putative functional effects. A unique feature effect information used SNP always up-to-date, because extracts from...
A new core–shell nanostructure consisting of inorganic hydroxyapatite (HAP) nanoparticles as the core and organic alginate shell (denoted HAP@Alg) was successfully synthesized by a pre-gel method applied to pH-responsive drug delivery systems (DDS). HAP@Alg have advantages alginate, where provides degradability, excellent biocompatibility COOH functionality. Through subsequent addition CaCl2 phosphate solutions solution, with controllable particle sizes (ranging from 160 650 nm) were...
Over 70% of cancer metastasis from prostate develops bone metastases that are not sensitive to hormonal therapy, radiation or chemotherapy. The epithelial-to-mesenchymal transition (EMT) genetic program is implicated as a significant contributor progression. As such, targeting the EMT represents an important therapeutic strategy for preventing treating metastasis. Berberine natural alkaloid with antitumor activities against many types cells. In this study, we investigated molecular mechanism...
Pectin, a major component of the primary cell wall, is synthesized in Golgi apparatus and exported to wall highly methylesterified form, then partially demethylesterified by pectin methylesterases (PMEs; EC 3.1.1.11). PME activity on status methylesterification profoundly affects properties and, thereby, critical for plant development defense response, although roles PMEs under heat stress (HS) are poorly understood. Functional genome annotation predicts that at least 66 potential genes...
Functionalized gold nanorods were successfully synthesized for the effective photothermal therapy of oral cancer.
Chemotherapy of bladder cancer has limited efficacy because the short retention time drugs in during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting iron oxide (Fe3O4) as core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate corona cell targeting (with composite denoted...
Potassium ferrate (K2FeO4) is a multi-functional green reagent for water treatment with considerable combined effectiveness in oxidization, disinfection, coagulation, sterilization, adsorption, and deodorization, producing environment friendly Fe(III) end-products during the reactions. This study uses simple method to lower Fe(VI) preparation cost by recycling iron from spent steel pickling liquid as an source preparing potassium wet oxidation method. The recycled powder form of ferrous...
Nootkatone is one of the major active ingredients Alpiniae oxyphyllae, which has been used as both food and medicinal plants for treatment diarrhea, ulceration, enuresis. In this study, we aimed to investigate whether nootkatone ameliorated progression chronic kidney diseases (CKD) clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that preventively decreased pathological changes significantly mitigated...
Background The relationship between cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphisms and lung cancer risk has been investigated in many studies, with inconclusive findings. Objectives We performed a comprehensive meta-analysis to evaluate the effects of CTLA-4 (−318C/T, +49A/G, CT60 A/G) on susceptibility. Methods Eligible studies were searched from PubMed, EMBASE, Web Science, Cochrane Library. Odds ratios their 95% confidence intervals calculated assess combined effect sizes....
Abstract Hydrogel-functionalized surface-based transducers demonstrate fluid-like kinetics, non-fouling properties, and superior biocompatibility. The integration of such properties three-dimensional (3D) micro- or macrostructure hydrogels into a mesoporous platform provides favorable moiety for incorporating biomolecule adsorption hybridization with capture agent. Herein, we report novel κ-carrageenan hydrogel-coated gold (Au) electrode (abbreviated as MPGE/gel) chronocoulometric (CC)...
Abstract The prospective of percutaneous drug delivery (PDD) mechanisms to address the limitations oral and injectable treatment for rheumatoid arthritis (RA) is increasing. These encompass inadequate compliance among patients acute gastrointestinal side effects. However, skin’s intrinsic layer can frequently hinder dispersion RA medications, thus mitigating efficiency delivery. To circumvent this constraint, we developed a strontium ranelate (SrR)-loaded alginate (ALG) phototherapeutic...
In this paper, we present an analytical and experimental study of the pressure barrier developed in axisymmetric microchannel with sudden expansion working as a capillary valve for regulating liquid flow microfluidics. The analysis is based on variation free energy liquid–solid–gas interfaces volume. at meniscus obtained rather simple form valid both hydrophilic hydrophobic channel walls. maximum barrier, termed burst pressure, necessary to stop found be function geometry liquid-channel...
Abstract In this work, the mechanisms responsible for adsorption of molybdate ions on alumina are investigated using in-depth surface analyses specimens immersed in solutions containing different at pH values. The obtained results reveal that when is an acidic solution ions, hydroxyl groups present removed to generate positively charged sites, and (MoO42− or AlMo6O24H63−) adsorbed via electrostatic interaction. Alumina dissolves slightly form AlMo6O24H63−, which more easily desorbed than...