A5047403830- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Dermatologic Treatments and Research
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Hair Growth and Disorders
- Chemokine receptors and signaling
- Pharmacological Effects of Natural Compounds
- Pharmacovigilance and Adverse Drug Reactions
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Spondyloarthritis Studies and Treatments
- Virus-based gene therapy research
- Vascular Tumors and Angiosarcomas
- Reproductive tract infections research
- melanin and skin pigmentation
- Nonmelanoma Skin Cancer Studies
- Immune cells in cancer
Dana-Farber Cancer Institute
2024-2025
Harvard University
2025
Lehigh Valley Hospital-Pocono
2025
Tehran University of Medical Sciences
2020-2023
Razi Hospital
2020-2023
Minia University
1989
Frontal fibrosing alopecia (FFA) is a scarring with no promising treatment.To evaluate the additive efficacy of oral isotretinoin to topical treatments.Between November 2017 and August 2018, FFA patients were randomly assigned receive either (20 mg/d) plus treatments (clobetasol 0.05% tacrolimus 0.1%) or monotherapy treatments. Treatments' was evaluated through Fibrosing Alopecia Severity Index (FFASI) after two 6 months.From 38 participants, 28 completed study. Facial papules improved...
The ongoing COVID-19 pandemic has raised concerns regarding the outcome of this infection in patients with autoimmune bullous dermatoses (AIBDs) due to effect drugs used treat these disorders. This investigation was performed from onset June 1, 2021. Patients AIBDs who contracted were evaluated. A generalized linear model employed find predictors severe among AIBDs. Ninety-three a mean age 50.3 years most related symptoms tiredness (76.3%) myalgia (69%), and cough (63.4%). During follow-up,...
CAR T cell therapy has revolutionized the treatment of a spectrum blood-related malignancies. However, responses vary among cancer types and patients. Accurate monitoring dynamics is crucial for understanding evaluating efficacy. Positron emission tomography (PET) offers comprehensive view homing, especially in critical organs such as lymphoid structures bone marrow. This information will help assess response predict relapse risk. Current PET imaging methods require genetic modifications,...
Port Wine Stain (PWS) is a congenital capillary malformation. Although multiple treatments are required, the gold standard treatment for PWS Pulsed Dye Laser (PDL). Given its anti-angiogenic effects, sirolimus can be considered as an adjuvant to PDL in PWS.To evaluate efficacy and safety of topical (Rapamycin) 0.2% cream therapy PWS.In this randomized double-blind placebo-controlled trial, 15 patients with were enrolled. Each lesion was divided into upper lower parts, each part assigned...
Introduction: Pemphigus vulgaris (PV) is an intraepidermal autoimmune bullous disease (AIBD) characterized by autoantibodies against desmosomal adhesion proteins, most commonly desmoglein (Dsg)3, leading to the suprabasal cleft formation and acantholysis.Areas covered: Direct immunofluorescence (DIF) indirect (IIF) studies display intercellular deposition of IgG/C3 throughout epidermis presence circulating respectively, as a net-like pattern. However, target antigen remains unknown using...
Background and Aim There have been concerns regarding the potential exacerbation of autoimmune bullous diseases (AIBDs) following vaccination against COVID-19 during pandemic. In current study, vaccine safety was evaluated in patients with AIBDs. Methods this AIBDs were contacted via face-to-face visits or phone calls. Patient demographics, vaccine-related information, pre- post-vaccine disease status, complications recorded. The considered either relapse remission/controlled phase worsening...
Psoriasis is a common chronic skin condition, which an immune-related hyperproliferative disorder. Among the different treatments for psoriasis, statins have been found to reduce severity of disease. Accordingly, fluvastatin and simvastatin are known anti-inflammatory effects by inhibiting inflammatory cytokines lymphocyte function. Narrowband ultraviolet B (NB-UVB) as effective safe modality psoriasis treatment. In this double blind, randomized controlled trial, we investigated efficacy...
This study determines the healing time of lesions on different locations and contributing factors to in patients with pemphigus.In this prospective study, newly diagnosed mucosal were included. A dermatologist evaluated lesions, disease status, side effects assigned PDAI. Follow-up visits conducted monthly until patient reached complete remission every three months thereafter. Tzanck smear was performed clinically suspected be herpetic origin.Sixty enrolled a mean age 45.9 ± 11.7 years. The...
Pemphigus is a rare group of autoimmune diseases, which its exact molecular pathogenesis and therapeutic biomarkers remained unknown. In this regard the expressions eight immune-related genes was evalualted in pemphigus patients. Forty-six patients, either new case or on minimal therapy, were recruited. The IL22, IL9, IL21, EBI3, TNFSF13B, FCGR3A, CTLA4, PDCD1 analyzed at baseline, compared with 32 healthy controls, their changes monitored 3 months after rituximab (RTX) therapy through...
Actinic keratosis (AK) is a pre-cancerous skin lesion, associated with development of squamous cell carcinoma. Current treatment options are limited.To compare the efficacy and safety topical 5-fluorouracil cream (5-FU) potassium hydroxide 5% (KOH) in AK.Eighteen patients AK applied KOH solution or 5-FU on each side their scalp/face, randomly. The these treatments were compared.Thirteen (118 lesions) ten (83 successfully followed for one three months, respectively. After month, showed better...
Psoriasis and its treatments may predispose patients to various infections. This is considered one of the most significant complications in with psoriasis.In present study, we aimed determine prevalence infection hospitalized psoriasis relationship systemic biologic treatments.All from 2018 2020 Razi Hospital Tehran, Iran, were studied cases recorded.Overall, 516 25 types 111 found. The common pharyngitis cellulitis, followed by oral candida, urinary tract infections, cold, fever unknown...
Nail involvement in subepidermal autoimmune blistering diseases (SEABD) is not common. Although these changes can be transient, permanent also occur. This study addresses nail manifestations and their associated factors patients with SEABD.From March 2020 to 2021, we enrolled 56 SEABD who were being examined at a tertiary skin hospital checked changes. We investigated the association between subtypes treatments that receiving abnormalities. Additional including age, gender, duration since...
Abstract Over the past few decades, a number of scoring instruments have been developed to assess severity and activity autoimmune bullous diseases (AIBDs) (Daneshpazhooh et al., 2019; Nili 2020; 2021; 2022). The Pemphigus Disease Area Index (PDAI), by International Definitions Group, is an easy‐to‐use, quick, reliable method for determining pemphigus severity. As effective tool in clinical trials, PDAI may also some limitations might require revisions be used on daily basis. Here, we...
Background . Treatment resistance to biologic treatment at specific sites in the body is a challenging issue. However, there insufficient evidence for factors affecting of these areas biological therapies. Methods In this study, patients with moderate‐to‐severetreatment‐resistant psoriasis who were naïve and referred Razi hospital included. The relationship between different demographic clinical variables was investigated. Results A total 131 biologic‐naïve treated anti‐TNF‐ α included...