A5056148466- Wound Healing and Treatments
- Toxoplasma gondii Research Studies
- Burn Injury Management and Outcomes
- Bacterial biofilms and quorum sensing
- Microbial Community Ecology and Physiology
- Vibrio bacteria research studies
- Autophagy in Disease and Therapy
- Herpesvirus Infections and Treatments
- Marine Invertebrate Physiology and Ecology
- Pancreatic and Hepatic Oncology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Spinal Cord Injury Research
- Planarian Biology and Electrostimulation
- Zebrafish Biomedical Research Applications
- Mosquito-borne diseases and control
- Hedgehog Signaling Pathway Studies
- Tumors and Oncological Cases
- Cytomegalovirus and herpesvirus research
University of Wisconsin–Madison
2024-2025
University of Michigan
2021-2022
Michigan United
2022
Many of the world’s warm-blooded species are chronically infected with Toxoplasma gondii tissue cysts, including an estimated one-third global human population. The cellular processes that permit long-term persistence within cyst largely unknown for T. and related coccidian parasites impact animal health. Herein, we show genetic ablation TgATG9 substantially reduces canonical autophagy compromises bradyzoite viability. Transmission electron microscopy revealed numerous structural...
Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH drives pediatric and adult cancers. frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-promoting tumor-restraining functions reported. Notably, the GLI family of transcription factors (GLI1, GLI2, GLI3), remain largely unexplored cancer. We therefore investigated individual combined contributions GLI1-3 to cancer progression. At pre-cancerous stages,...
Biofilms are three-dimensional structures containing one or more bacterial species embedded in extracellular polymeric substances. Although most biofilms stationary, Flavobacterium johnsoniae forms a motile spherical biofilm called zorb, which is propelled by its base cells and contains polysaccharide core. Here, we report the formation of spatially organized, motile, multispecies biofilms, designated “co-zorbs,” that distinguished core–shell structure. F. zorbs whose collect other transport...
ABSTRACT Secondary fungal infections represent a major complication following thermal injuries. However, the mechanisms of colonization burn tissue and how host subsequently responds to fungi within this niche remain unclear. We have previously reported zebrafish model injury that recapitulates many features human wounds. Here, we characterize host-fungal interaction dynamics wound using two most common pathogens isolated from injuries, Aspergillus fumigatus Candida albicans . Both A. C....
Burn injuries undergo a complex healing process in which progressive spreading of epithelial damage can lead to secondary complications such as wound infection, is major driver mortality among burn patients. We recently reported that burning larval zebrafish triggers dysregulated keratinocyte dynamics compared mechanical injury. Here, we investigate behaviour following injury and the subsequent potential for microbial colonisation wounds over time. Real-time imaging, coupled with tracking...
Abstract Burn injuries undergo a complex healing process in which progressive spreading of epithelial damage can lead to secondary complications such as wound infection, is major driver mortality among burn patients. We recently reported that burning larval zebrafish triggers dysregulated keratinocyte dynamics compared mechanical injury. Here, we investigate behavior following injury and the subsequent potential for microbial colonization wounds over time. Real-time imaging, coupled with...
Abstract Biofilms are three-dimensional structures containing one or more bacterial species embedded in extracellular polymeric substances. Although most biofilms stationary, Flavobacterium johnsoniae forms a motile spherical biofilm called zorb, which is propelled by its base cells and contains polysaccharide core. Here, we report formation of spatially organized, motile, multispecies biofilms, designated “co-zorbs,” that distinguished core-shell structure. F. zorbs whose collect other...
Secondary fungal infections represent a major complication following thermal injuries. However, the mechanisms of colonization burn tissue and how host subsequently responds to fungi within this niche remain unclear. We have previously reported zebrafish model injury that recapitulates many features human wounds. Here, we characterize host-fungal interaction dynamics wound using two most common pathogens isolated from injuries,