A5079711254- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Nitric Oxide and Endothelin Effects
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Carcinogens and Genotoxicity Assessment
- Cancer Mechanisms and Therapy
- Microtubule and mitosis dynamics
- Advanced Proteomics Techniques and Applications
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- bioluminescence and chemiluminescence research
- Renin-Angiotensin System Studies
- Fungal and yeast genetics research
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Hormonal Regulation and Hypertension
- FOXO transcription factor regulation
- Peptidase Inhibition and Analysis
Instituto Maimónides de Investigación Biomédica de Córdoba
2015-2020
Centro de Investigación Biomédica en Red de Cáncer
2017-2019
University of Córdoba
2015-2016
Instituto de Salud Carlos III
2015-2016
Hospital Universitario Reina Sofía
2015-2016
Instituto de Biología Funcional y Genómica
2012
Universidad de Salamanca
2005-2012
Consejo Superior de Investigaciones Científicas
2008-2010
Abstract Genomic integrity is threatened by multiple sources of DNA damage. double-strand breaks (DSBs) are among the most dangerous types lesions and can be generated endogenous or exogenous agents, but they arise also during replication. Sister chromatid recombination (SCR) a key mechanism for repair DSBs replication it fundamental maintaining genomic stability. Proper relies on several factors, which histone modifications play important roles in response to DSBs. Here, we study role H3K79...
Regulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage eukaryotes. Although evolutionary conserved mechanism is well understood, deubiquitylation ubPCNA remains poorly characterized. Here, we show that histone H2B(K123) ubiquitin protease Ubp10 also deubiquitylates Saccharomyces cerevisiae. Our results sustain Ubp10-dependent sliding clamp normally takes place during S phase, likely response simple presence ubPCNA. In agreement with this, forms complex vivo....
Abstract Maintenance of genomic integrity relies on a proper response to DNA injuries integrated by the damage checkpoint; histone modifications play an important role in this response. Dot1 methylates lysine 79 H3. In Saccharomyces cerevisiae, is required for meiotic recombination checkpoint as well chromatin silencing and G1/S intra-S checkpoints vegetative cells. Here, we report analysis function alkylating damage. Unexpectedly, deletion DOT1 results increased resistance agent methyl...
Despite the demonstrated benefits of anti-EGFR/VEGF targeted therapies in metastatic colorectal cancer (mCRC), many patients initially respond, but then show evidence disease progression. New therapeutic strategies are needed to make action available drugs more efficient. Our study aimed explore whether simultaneous targeting EGFR/VEGF and cyclooxygenase-2 (COX-2) may aid treatment management mCRC patients. The dual tyrosine kinase inhibitor AEE788 celecoxib were used inhibit EGFR/VEGFR...
Nitric oxide (NO) has been highlighted as an important agent in cancer-related events. Although the inducible nitric synthase (iNOS) isoform received most attention, recent studies literature indicate that endothelial isoenzyme (eNOS) can also modulate different tumor processes including resistance, angiogenesis, invasion, and metastasis. However, role of eNOS cancer stem cell (CSC) biology mesenchymal tumors is unknown. Here, we show was significantly upregulated VilCre ERT2 Apc fl/+ fl/fl...
Currently, there are no predictive biomarkers for anti-angiogenic strategies in cancer, but response to drugs is associated with development of hypertension secondary treatment. Therefore, this study explored the clinical relevance genetic polymorphisms some components renin-angiotensin system (RAS).Genomic DNA was isolated from peripheral blood 95 metastatic breast or colorectal cancer patients treated bevacizumab, and AGTR1-A1166C (rs5186), AGT-M235T (rs699) SNPs ACE I/D (rs4646994) were...
// Araceli Valverde 1 , Jon Peñarando 1, 2 Amanda Cañas Laura M. López-Sánchez Francisco Conde Silvia Guil-Luna Vanessa Hernández Carlos Villar 3 Cristina Morales-Estévez 4 Juan de la Haba-Rodríguez 2, Enrique Aranda Antonio Rodríguez-Ariza Instituto Maimónides Investigación Biomédica Córdoba (IMIBIC), Córdoba, Spain Centro Investigacion en Red Cáncer, Madrid, Unidad Gestión Clínica Anatomía Patológica, Hospital Universitario Reina Sofía, Oncología, Correspondence to: Rodríguez-Ariza, email:...
Abstract Newly emerged proteomic methodologies, particularly data‐independent acquisition (DIA) analysis–related approaches, would improve current gene expression–based classifications of colorectal cancer (CRC). Therefore, this study was aimed to identify protein expression signatures using SWATH‐MS DIA and targeted data extraction, aid in the classification molecular subtypes CRC advance diagnosis development new drugs. For purpose, 40 human samples 7 healthy tissue were subjected...