A5105984434- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Random lasers and scattering media
- Immunotherapy and Immune Responses
- Impact of Technology on Adolescents
- Cancer-related gene regulation
- Exercise and Physiological Responses
- Lipid Membrane Structure and Behavior
- Peripheral Nerve Disorders
- RNA regulation and disease
- T-cell and B-cell Immunology
- Congenital heart defects research
- Inhalation and Respiratory Drug Delivery
- Digital Games and Media
- Ultrasound and Hyperthermia Applications
- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
Federazione Medico Sportiva Italiana
2023
ETH Zurich
2022-2023
Neuroscience Institute
2022
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022
University of Palermo
2020-2021
University of Münster
2004-2020
Max Planck Institute for Brain Research
2005-2020
Philipps University of Marburg
2014-2018
Heidelberg University
2007-2011
University Hospital Heidelberg
2007-2011
Previous studies have demonstrated that microribonucleic acids (miRs) are key regulators of protein expression in the brain and modulate dendritic spine morphology synaptic activity. To identify novel miRs involved neuronal plasticity, we exposed adult mice to chronic treatments with nicotine, cocaine, or amphetamine, which psychoactive drugs induce well-documented neuroadaptations. We observed region– drug-specific changes miR levels identified miR-29a/b as morphology. In vitro imaging...
The proper development and function of neuronal circuits rely on a tightly regulated balance between excitatory inhibitory (E/I) synaptic transmission, disrupting this can cause neurodevelopmental disorders, for example, schizophrenia. MicroRNA-dependent gene regulation in pyramidal neurons is important cognition, but its role interneurons poorly understood. Here, we identify miR138-5p as regulator short-term memory transmission the mouse hippocampus. Sponge-mediated inactivation...
Neuronal activity controls the correct establishment and refinement of neuronal circuits by regulating key aspects such as dendritogenesis spine development. Both transcriptional post-transcriptional gene expression programs induced have to be coordinated in a tight spatio-temporal manner order for proper functioning neuron. In this context microRNAs (miRNAs), which are implicated regulation, good candidates control dendritic recent study we demonstrated that induces myocyte enhancing factor...
The semaphorins are a large family of proteins involved in the patterning both vascular and nervous systems. In order to analyze function membrane-bound semaphorin 5A (Sema5A), we generated mice homozygous for null mutation Sema5a gene. Homozygous mutants die between embryonic development days 11.5 (E11.5) E12.5, indicating an essential role Sema5A during development. Mutant embryos did not show any morphological defects that could account lethality mutation. A detailed analysis system...
The secreted semaphorin 3A (Sema3A) is a member of large family proteins that act as guidance signals for axons and dendrites. While the receptors signaling pathways mediate repulsive effects semaphorins are beginning to be understood in some detail, mechanisms responsible ability Sema3A stimulate extension dendrites remain elucidated. Here we show PC12 cells, model widely used study neuronal differentiation, can dissect this pathway. effective nerve growth factor stimulating neurites from...
The reality of eSports is something much more complex than individual users playing video games. There are several characteristics that have in common with traditional sports: from the spirit competition to structural composition teams, including increase performance training and practice, up injuries physical psychological stress athlete. number scientific papers interested this still relatively low, although recent years there has been a significant regard. Probably lack knowledge world by...
Two novel HLA class I alleles, HLA-A*03:409 and -B*49:72 were characterized by next generation sequencing.
The currently available nebulization devices have a slow aerosol flow and produce vapor with large microdrops. Improved that achieve higher airflow smaller microdrops are needed to improve the clinical care of patients. To address this critical need, we developed novel system for molecular vaporization liquids. This device vaporizes an active pharmacological substance dissolved in water, alcohol, or mixture water alcohol using two energy sources at same time: high-frequency ultrasound...
Abstract Social deficits are frequently observed in patients suffering from neurodevelopmental disorders, but the molecular mechanisms regulating sociability still poorly understood. We recently reported that loss of microRNA cluster miR-379-410 leads to hypersocial behavior and anxiety mice. Here, we show ablating excitatory neurons postnatal mouse hippocampus recapitulates hypersociability, not anxiety. At cellular level, increased synaptic transmission upregulation an actomyosin gene...
We study the DVCS amplitude within color dipole approach employing a nonperturbative wave function for real photon. found that model is able to decribe absolute value of cross section and t‐slope, but predicts too steep Q2‐dependence in comparison with H1 data.