A5008745959- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Plant responses to water stress
- Sirtuins and Resveratrol in Medicine
- Genomics and Chromatin Dynamics
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- Spaceflight effects on biology
- Tryptophan and brain disorders
- Hedgehog Signaling Pathway Studies
- Advanced Glycation End Products research
- Nuclear Receptors and Signaling
- Cassava research and cyanide
- NF-κB Signaling Pathways
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- Circadian rhythm and melatonin
- Heat shock proteins research
National Yang Ming Chiao Tung University
2004-2022
The University of Texas Southwestern Medical Center
2016-2022
University of Michigan
2011-2012
Michigan United
2012
Autophagy, a lysosomal degradation pathway, plays crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension. Thus, pharmacological stimulation autophagy may be an effective approach for preventing or treating certain human diseases and/or aging. We sought to establish method developing new chemical compounds that specifically induce autophagy. To do this, we developed two assays identify target key...
Abstract Purpose: Head and neck squamous cell carcinoma (HNSCC) represents the sixth most frequent type of cancer worldwide. However, molecular genetic alterations underlying its malignant behavior progression are little known. We showed previously that c-MYC directly activates expression DNA double-strand break repair gene NBS1, NBS1 overexpression contributes to transformation. Here, we investigate role in HNSCC. Experimental Design: Immunohistochemistry analysis was done 81 locally...
FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses longevity. Here we show that the Caenorhabditis elegans SIR-2.4—homolog of mammalian SIRT6 SIRT7 proteins—promotes DAF-16–dependent stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, proteotoxicity. By contrast, largely dispensable localization function in response reduced...
Nijmegen breakage syndrome (NBS) is a chromosomal instability associated with cancer predisposition, radiosensitivity, microcephaly, and growth retardation. The NBS gene product, NBS1 (p95) or nibrin, part of the hMre11 complex, central player double strand break repair. We previously demonstrated that c-Myc directly activates expression. Here we have shown constitutive expression in Rat1a HeLa cells induces/enhances their transformation. Repression endogenous levels using short interference...
One goal of aging research is to develop interventions that combat age-related illnesses and slow aging. Although numerous mutations have been shown achieve this in various model organisms, only a handful chemicals identified Here, we report celecoxib, nonsteroidal anti-inflammatory drug widely used treat pain inflammation, extends Caenorhabditis elegans lifespan delays the age-associated physiological changes, such as motor activity decline. Celecoxib also progression proteotoxicity well...
Autophagy plays essential roles in a wide variety of physiological processes, such as cellular homeostasis, metabolism, development, differentiation, and immunity. Selective pharmacological modulation autophagy is considered valuable potential therapeutic approach to treat diverse human diseases. However, development therapies has been greatly impeded by the lack specific small molecule modulators. Here, we performed structure–activity relationship studies on previously discovered weak Bcl-2...