A5100398808- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Migraine and Headache Studies
- Cerebrospinal fluid and hydrocephalus
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Retinal Diseases and Treatments
- Neonatal and fetal brain pathology
- Photoreceptor and optogenetics research
- Ion Channels and Receptors
- Spinal Dysraphism and Malformations
- Radiomics and Machine Learning in Medical Imaging
- Neurological and metabolic disorders
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Phytochemicals and Antioxidant Activities
- Postharvest Quality and Shelf Life Management
- Laser Applications in Dentistry and Medicine
- Nitric Oxide and Endothelin Effects
- Lipid metabolism and disorders
- Organic Light-Emitting Diodes Research
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2025
Wenzhou Medical University
2017-2025
Zhoushan Hospital
2025
Jinhua Central Hospital
2025
Hebei General Hospital
2025
Tongde Hospital of Zhejiang Province
2025
Wenzhou Institute of Technology Testing & Calibration
2024-2025
Shandong University of Traditional Chinese Medicine
2024
Shanghai Maritime University
2024
Dalian University of Technology
2019-2022
Abstract Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since model cannot accurately describe coefficient of nerve fibre crossing region, we proposed a kurtosis ALPS (DKI-ALPS) Methods study included 29 healthy controls and 37 We data from 3T MRI scanner calculate DTI-ALPS DKI-ALPS indices two groups. compared between groups using two-sample t-test...
<h3>Background:</h3> Both depressive symptoms and neurotransmitter changes affect the characteristics of functional brain networks in clinical patients. We sought to explore how grading is organized among patients with mild cognitive impairment (D-MCI) whether organization are related distribution. <h3>Methods:</h3> Using 3 T magnetic resonance imaging (MRI) we acquired MRI (fMRI) data from D-MCI, without depression (nD-MCI), healthy controls. used resting-state fMRI diffusion embedding...
Abstract Background Depression is a common symptom of Alzheimer’s disease (AD), but the underlying neural mechanism unknown. The aim this study was to explore topological properties AD patients with depressive symptoms (D-AD) using graph theoretical analysis. Methods We obtained 3-Tesla rsfMRI data from 24 D-AD patients, 20 non-depressed (nD-AD), and normal controls (NC). Resting state networks were identified theory ANOVA two-sample t -test post hoc analysis in GRETNA used assess...
Objectives: The periaqueductal gray (PAG) is a key region in the descending pain modulatory system. We applied Granger causality analysis-based approach to examine resting-state effective connectivity of bilateral PAG regions migraine patients without aura (MwoA). Materials and Methods: Resting-state functional magnetic resonance imaging data were obtained from 28 MwoA 17 healthy controls. was characterized using voxel-wised analysis method. resulting measurements assessed for correlations...
Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while dynamic changes associated with onset and progression PD remain unclear. Herein, in metabolites were detected from initiation development 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced Parkinsonism model elucidate its potential metabolic mechanism. Ex vivo 1H nuclear magnetic resonance (NMR) spectroscopy was used measure metabolite striatum substantia nigra (SN) mice at 1, 7, 21 days...
Abstract Background The neurophysiological mechanisms underlying cognitive deficits in non-alcoholic fatty liver disease (NAFLD) remain unknown. Cognitive changes may be caused by brain alterations neural activity and functional connectivity (FC). Aim This study aims to investigate the between spontaneous FC male NAFLD patients relationship of with performance. Methods In this prospective study, 33 pre-cirrhosis subjects 20 controls matched for age, education level, body mass index. All...
INTRODUCTION: In metabolic dysfunction–associated steatotic liver disease, the diagnostic efficacy of controlled attenuation parameter (CAP) was not very accurate in evaluating fat content. The aim this study to develop a score, based on CAP and conventional clinical parameters, improve performance regarding METHODS: A total 373 participants from 2 independent Chinese cohorts were included divided into derivation (n = 191), internal validation 75), external 107) cohorts. Based significant...
This paper reviews the development history of electrodes and common types, addressing biocompatibility electrochemical performance issues their advances future directions.
The anterior cingulate gyrus (ACG) is an important regulatory region for pain-related information. However, the ACG composed of subregions with different functions. mechanisms underlying brain networks in patients migraine without aura (MwoA) are currently unclear.
Chronic alcohol consumption causes cognitive impairments accompanying with white matter atrophy. Recent evidence has shown that myelin dynamics remain active and are important for brain functions in adulthood. For example, new generation is required learning memory functions. However, it remains undetermined whether exposure can alter In this study, we examine the effect of chronic on by using genetic approaches to label newly generated (NG2-CreERt; mT/mG). Our results indicated (either 5%...
// Xue Wang 1, * , Yu Zhao 2, Yumin Hu 1 Yongjin Zhou Xinjian Ye Kun Liu Guanghui Bai Anna Guo Meimei Du Lezhen Jiang Jinhong 3, and Zhihan Yan Department of Radiology, The Second Affiliated Hospital Yuying Children′s Wenzhou Medical University, 325027, China 2 Gynecology Obstetrics, 3 Imaging, Shanghai Mental Health Center, Jiao Tong University School Medicine, 200030, These authors contributed equally to this work Correspondence to: Yan, email: yanzhihanwz@163.com Wang,...
In recent years, several functional imaging studies have shown that the hypothalamus is closely associated with migraine and suggested may be a potential site of generation. Studying characteristics network in persons migraines help to understand neural mechanisms migraine. We thus used resting-state magnetic resonance (rsfMRI) Granger causal analysis investigate effective connectivity (EC) migraines.
Increasing evidence has shown that astrocytes are implicated in regulating oligodendrocyte myelination, but the underlying mechanisms remain largely unknown. To understand whether microRNAs function oligodendroglial differentiation and myelination developing adult CNS, we generated inducible astrocyte-specific Dicer conditional knockout mice (hGFAP-CreERT; fl/fl). By using a reporter mouse line (mT/mG), confirmed hGFAP-CreERT drives an efficient recombination upon tamoxifen treatment from...
Object: Diabetes is associated with cerebral vascular dysfunction and increased cognitive impairment. The objective of this study was to use arterial spin labeling (ASL) perfusion-weighted magnetic resonance imaging investigate whether perfusion changed in newly-diagnosed children type 1 diabetes mellitus (T1DM) the possible relationship between aberrant blood flow (CBF) as well clinical variables. Methods: Between January 2017 February 2018, 34 T1DM age, gender, education-matched healthy...
Type 1 diabetes mellitus (T1DM) causes cognitive changes in children, which may be due to deficits brain functions. It is unclear whether T1DM children will have functional during the initial stage of disease. We aimed investigate network topology with new-onset T1DM. In this study, thirty-five and thirty-three age-, sex-matched healthy controls underwent resting-state fMRI. The whole connectivity density (FCD) analysis seed-based (FC) were performed networks when compared controls. Pearson...
Recent studies have shown that the reduction of sperm count is associated with sleep behaviors, including restricted/excessive duration, late time midpoint, and shift midpoint (social jetlag). Chronotype suggested to regulate behaviors; however, relationship between chronotype human unknown. The behaviors count, when as well are controlled also unclear. We performed a path analysis data obtained from 667 Chinese men recruited into MARHCS (Male Reproductive Health in Chongqing College...
ABSTRACT Transient receptor potential (TRP) channels have been found to play important roles in cellular physiology and hold promise as therapeutic targets. These activate response a variety of chemical or physical stimuli conduct non-selective cation currents (NSCC). Due their unique activation properties, application automated electrophysiology measure the channel activity has difficult. Using HEK293 cells stably expressing human TRP channels, hTRPC6 hTRPA1, we developed validated...