A5101794085- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- interferon and immune responses
- RNA modifications and cancer
- Boron Compounds in Chemistry
- Cancer, Lipids, and Metabolism
- Healthcare Systems and Public Health
- Tactile and Sensory Interactions
- Wnt/β-catenin signaling in development and cancer
- Distributed Control Multi-Agent Systems
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Dendrimers and Hyperbranched Polymers
- Phytoestrogen effects and research
- MicroRNA in disease regulation
- Cardiac Health and Mental Health
- Sirtuins and Resveratrol in Medicine
- Photoacoustic and Ultrasonic Imaging
- Adenosine and Purinergic Signaling
- Myasthenia Gravis and Thymoma
- Neuroblastoma Research and Treatments
- Antimicrobial Peptides and Activities
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
Bengbu Medical College
2014-2024
Sun Yat-sen University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Guangxi University of Chinese Medicine
2024
University of Electronic Science and Technology of China
2024
Nankai University
2023
First Affiliated Hospital of Bengbu Medical College
2016-2022
Heilongjiang University of Chinese Medicine
2022
Dalian Maritime University
2022
Wenzhou Medical University
2015-2016
Breast cancer is the most common female malignant disease, and second leading cause of cancer-related death in United States. Acquired resistance to chemotherapeutic drugs a pivotal reason that leads worse treatment outcome breast cancer. Therefore, it urgent elucidate mechanism drug cancer.To investigate underlying molecular basis acquired resistant cells paclitaxel cancer, we used multiple methods including real-time RT-PCR, western blotting analysis, migration invasion assays, wound...
// Zelai He 1,2 , Jingwen Huang 2 Yuanyuan Xu 3 Xiangyu Zhang Yanwei Teng Can Yufeng Wu 4 Xi Huijun 5 and Wenjie Sun 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Medical College, University, Shanghai, China The Second Affiliated Hospital Yuying Children's Wenzhou Wenzhou, State Key Laboratory Oncogenes Related Genes, Institute, Renji Hospital, School Medicine, Jiao Tong Internal Zhengzhou Henan Zhengzhou, Cardio-thoracic Surgery, Huashan Correspondence to:...
Prostate cancer is one of the most common cancers threatening public health worldwide. Although chemotherapy plays an important role in treating prostate cancer, it leads to many adverse effects and prone drug resistance. Quercetin, a natural product, used traditional Chinese medicine because its strong antitumor activity few side effects.In this study, we combined quercetin paclitaxel kill cells vivo vitro, investigated relevant mechanism combination treatment. After were treated with...
Background To investigate the role of microglia polarization in pathogenesis diabetic retinopathy, and study mechanism ALKBH5-mediated m 6 A modification A20 retinal polarization. Methods Diabetics rats were constructed M1/M2 was determined using immunofluorescence, flow cytometry, quantitative real-time PCR (qRT-PCR). Glucose at different concentrations added to treat microglia, rate detected. RNA sequencing performed identify differentially expressed gene glucose treated expression...
Introduction: Lung cancer's high incidence and dismal prognosis with traditional treatments like surgery radiotherapy necessitate innovative approaches. Despite advancements in nanotherapy, the limitations of single-treatment modalities significant side effects persist. To tackle lung cancer effectively, we devised a temperature-sensitive hydrogel-based local injection system near-infrared triggered drug release. Utilizing 2D MXene nanosheets as carriers loaded R837 cisplatin (DDP),...
CXC chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) have important roles in promoting tumour growth metastasis. Therefore, targeting CXCR4 could be a promising strategy for treatment of human cancer. To achieve this goal, we developed highly purified recombination polypeptide (GST-NT21MP), which is synthetic 21-mer peptide antagonist (NT21MP) derived from the viral macrophage inflammatory protein II by fermentation technology,...
Abstract Electronic skins are expected to replicate a human‐like tactile sense, which significantly detects surface information, including geometry, material, and temperature. Although most texture features can be sensed in the horizontal direction, lack of effective approaches for detecting vertical properties limits development artificial skin based on sensors. In this study, an all‐printed finger‐inspired sensor array is developed realize 3D detection reconstruction microscale structures....
<title>Abstract</title> RNA modification recognition proteins are crucial in cancer development and progression. Among all modification-related (RMRPs), Weighted Gene Co-expression Network Analysis (WGCNA), along with comprehensive thorough analysis, suggests that NAT10, the sole known writer of N4-acetylcysteine (ac4C), as a critical regulatory protein associated colorectal (CRC) NAT10 facilitates malignancy DNA damage repair CRC cells via its ac4C transferase activity regulation Peter Pan...
Long noncoding RNAs (lncRNAs) stand as indispensable regulators of initiation and development in melanoma (melanoma). However, the action molecular mechanisms linked to remain unclear. In current study, findings revealed that AGAP2-AS1 was considerably greater than healthy tissues level cancer tissue significantly cancerous TNM stage patients. Individuals with high had a shorter survival duration patients low AGAP2-AS1, regardless progression-free or overall survival. Functionally,...
// Zelai He 1, 3, * , Xiangyu Zhang 4, Jingwen Huang Yufeng Wu 5 Xuanzhang 1 Jie Chen Junyong Xia 6 Hao Jiang 3 Jing Ma 2 Jian The Second Affiliated Hospital and Yuying Children's of Wenzhou Medical University, Wenzhou, China Ultrasonic Department, Shanghai Songjiang Center Hospital, Shanghai, First Bengbu College, Bengbu, 4 Department Pathology, Jining No.1 Peoples' Jining, Internal Medicine, Cancer Zhengzhou Henan Zhengzhou, Nuclear Provincial Anhui Hefei, These authors contributed equally...
Exercise is a vital adjunct therapy for patients with hypertension comorbidities. However, medical personnel and face significant obstacles in implementing exercise prescription recommendations. AI has been developed as beneficial tool the healthcare field. The performance of intelligent tools such ChatGPT 4.0 Intelligent Health Promotion Systems (IHPS) issuing prescriptions comorbidities remains to be verified.
As there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies. Actually, interaction between cells and microenvironment plays important role in especially Sonic hedgehog protein (SHH) signaling microenvironment. The SHH promotes osteoblast maturation then secretes RANKL induce osteoclastogenesis. Herein, this study develops bone-targeting calcium phosphate lipid hybrid nanoparticles (NPs)...
Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy chemotherapy are modest. Although targeted therapy immunotherapy have been a topic of significant research in recent years, scientific developments not yet translated to for patients TNBC. In view these current treatment shortcomings, we designed silica nanosystem (SNS) Nano-Ag as the core complex MnO2 doxorubicin (Dox) surrounding mesoporous shell. This system was...
(Arginine-Glycine-Aspartic)-methoxy polyethylene glycol-(1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N) (abbreviation: RGD-PEG2000-DSPE or RGD-PD) was successfully synthesized and verified by 1H-NMR MALDI-TOF MS. Polyethylene glycol-poly-L-lysine/RGD-PD/phospholipid/calcium phosphate nanoparticles (PEG-PLL/RGD-PD/PL/CaP NPs MNPs) were prepared using a novel, simple method conducted at room temperature. Transmission electron microscopy (TEM) analysis showed that the MNPs spheres of...
Abstract: Type AB thymoma associated with multiple metastases is rarely encountered. This paper describes the therapeutic effect of new radiotherapy, helical tomotherapy (TOMO), in a patient metastases. A male aged 52 was diagnosed as type Two-cycle chemotherapy administered primary therapy. The efficacy evaluation indicated progressive disease (PD), so radiotherapy added to initial treatment. re-evaluation PD under and partial response (PR) area, latter treatment changed TOMO. TOMO...
Breast cancer (BC) is the most common type of among women worldwide, and about 30% males will have recurrent disease.In order to treat BC, we designed a silica nanodelivery system loaded with epirubicin curcumin (composite nanoparticles, CNPs). To promote CNPs clinical application, stability, blood, immune cell compatibility, skin stimulation experiments, anti-tumor activity in vivo vitro were studied.In our study, had particle size 73.9 nm uniform morphology; moreover, they maintained...
In the route planning of international multimodal transport, it is impossible to design optimal simply by taking minimum freight as standard. Under assumption rational economic man, considering increasingly high depreciation rate, yield rate and capital occupation goods, relationship between value goods transportation time close. Therefore, function model constructed empirical analysis Tokyo Duisburg carried out.
Abstract Toll-like receptor 8 (TLR8) is encoded by the TLR8 gene and belongs to family of toll-like receptors (TLRs). predominantly expressed in lung peripheral blood leukocytes. Close locus, another TLR member, TLR7, also located on chromosome X potentially can be manipulated TLR8. an endosomal that recognizes single-stranded RNA (ssRNA) viruses. After exogenous ssRNA infection, will recruit MyD88 activate downstream signaling. Similarly, miRNAs secreted from tumor cells lead activation...