A5067128983- Protein Tyrosine Phosphatases
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- interferon and immune responses
- Wnt/β-catenin signaling in development and cancer
- Phytochemicals and Antioxidant Activities
- Melanoma and MAPK Pathways
- Meat and Animal Product Quality
- Synthesis of heterocyclic compounds
- Galectins and Cancer Biology
- Animal Nutrition and Physiology
- Sulfur-Based Synthesis Techniques
- Protein Kinase Regulation and GTPase Signaling
- NF-κB Signaling Pathways
- Lymphatic System and Diseases
- Computational Drug Discovery Methods
- Congenital heart defects research
- Synthesis and Reactivity of Sulfur-Containing Compounds
Zoetis (United States)
2025
University of Kentucky
2017-2022
Shoc2 is a scaffold protein critical for regulating Raf-1 kinase activation and the amplitude of ERK1/2 signals. Hereditary mutations result in Noonan Syndrome with Loose anagen Hair (NSLH), debilitating congenital disorder associated lymphatic abnormalities. We demonstrate that zebrafish null larvae exhibit nearly complete loss vasculature, suggesting gene plays positive role during developmental lymphangiogenesis. The lymphatics caused by deficiency can be rescued endothelial autonomous...
The extracellular signal-related kinase 1 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essential functions in development. scaffold protein Shoc2 amplifies the activity of ERK1/2 an modulator variety inputs. Germline mutations are associated human developmental disease known as Noonan-like syndrome loose anagen hair. Clinical manifestations this include congenital heart defects, delays, distinctive facial abnormalities, reduced growth cognitive deficits along...
ABSTRACT The ERK1/2 (also known as MAPK3 and MAPK1, respectively) signaling pathway is critical in organismal development tissue morphogenesis. Deregulation of this leads to congenital abnormalities with severe developmental dysmorphisms. core cascade relies on scaffold proteins, such Shoc2 guide fine-tune its signals. Mutations SHOC2 lead the pathology termed Noonan-like Syndrome Loose Anagen Hair (NSLAH). However, mechanisms underlying functions contributions disease progression remain...
The ERK1/2 signaling pathway is critical in organismal development and tissue morphogenesis. Deregulation of this leads to congenital abnormalities with severe developmental dysmorphisms, i.e. RASopathies. core cascade relies on scaffold proteins such as Shoc2 guide fine-tune its signals. Mutations shoc2 lead the pathology termed Noonan-like Syndrome Loose Anagen Hair (NSLAH) RASopathy. However, mechanisms underlying functions contributions disease progression remain unclear. We found that...
The extracellularly‐regulated kinase ‐1 and ‐2 (ERK1/2) signaling pathway utilizes a network of proteins events to control many downstream effectors for cell proliferation, apoptosis, differentiation, motility. broad scope ERK1/2's branched capacity requires integrated fine‐tuning specific control. To this end, the scaffolding – essential regulatory facilitate activities enzymes in pathway. Shoc2, critical protein within ERK1/2 pathway, serves as platform create temporal spatial...
Dysregulation of the extracellular-signal-regulated kinase 1/2 (ERK1/2) pathway results in common developmental syndromes - RASopathies. Our lab studies a RASopathy called Noonan syndrome with loose anagen hair (NSLAH). This is caused by mutations critical regulator ERK1/2 pathway, Shoc2. Patients harboring shoc2mutations have structural deficiencies among RASopathies (e.g., altered pigmentation, craniofacial defects, valve disorders). Many NSLAH features could involve defects development...
ABSTRACT The extracellular signal-regulated kinase (ERK1/2) pathway is essential in embryonic development. scaffold protein Shoc2 a critical modulator of ERK1/2 signals, and mutations the shoc2 gene lead to human developmental disease known as Noonan-like syndrome with loose anagen hair (NSLH). loss NSLH-causing affect tissues neural crest (NC) origin. In this study, we utilized zebrafish model dissect role Shoc2-ERK1/2 signals development NC. These studies established that significantly...