A5102283938- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Breast Implant and Reconstruction
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Molecular Biology Techniques and Applications
- Kruppel-like factors research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Tannin, Tannase and Anticancer Activities
- Eosinophilic Disorders and Syndromes
- Cancer Research and Treatments
- Regulation of Appetite and Obesity
- Colorectal and Anal Carcinomas
- PARP inhibition in cancer therapy
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Fibroblast Growth Factor Research
First Affiliated Hospital of Bengbu Medical College
2009-2025
Bengbu Medical College
2012-2024
PURPOSE The global, phase 3, open-label, randomized TROPION-Breast01 study assessed the trophoblast cell surface antigen 2–directed antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) versus investigator's choice of chemotherapy (ICC) in hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–) breast cancer. METHODS Adult patients with inoperable/metastatic HR+/HER2‒ cancer, who had disease progression on endocrine therapy, for whom therapy was...
Background: Oxaliplatin (OXA)-based chemotherapy is critical in the management of advanced hepatocellular carcinoma (HCC); however, acquired drug resistance has largely restricted its clinical efficacy. This study aims to explore key mechanisms and regulatory factors determining chemosensitivity HCC. Methods: We developed OXA-resistant (OR) HCC cells used multiple methods, including real-time RT-PCR, Western blot, immunofluorescence, transwell invasion assay, wound-healing MTT gene...
1019 Background: TROP2 (trophoblast cell surface antigen 2) is highly expressed in TNBC and associated with poor survival. Sac-TMT (MK-2870/SKB264) a ADC developed novel linker to conjugate the payload, belotecan-derivative topoisomerase I inhibitor. It approved China for pts a/mTNBC who have received at least two prior chemotherapies, including one metastatic disease. The Phase II OptiTROP-Breast05 study (NCT05445908) evaluated sac-TMT as first-line treatment a/mTNBC. also explored impact...
Colorectal cancer (CRC) causes significant mortalities worldwide. Fibroblast growth factor (FGF) receptor (FGFR) signaling is frequently dysregulated and/or constitutively activated in CRCs, contributing to carcinogenesis and progression. Here, we studied the activity of AZD-4547, a novel potent FGFR kinase inhibitor, on CRC cells. AZD-4547 inhibited cell vitro, its correlated with FGFR-1/2 expression level. was cytotoxic pro-apoptotic FGFR-1/2-expressed lines (NCI-H716 HCT-116), but not...
The study aimed to culture organoids from tissues of patients with breast cancer (BC) and use the measure sensitivity quercetin its combination chemotherapeutic agents.
The aim of the present meta-analysis compared left colic artery (LCA) preservation with non-preservation in laparoscopic resection rectal cancer terms feasibility, efficacy and safety. PubMed, Ovid, Embase, Web Science, CBM, CNKI, VIP WanFang Data databases were searched prior to June 2017 for studies comparing LCA cancer. Two researchers screened literature independently, extracted data evaluated risk bias. study was performed using RevMan 5.3 software meta-analysis. A total 10 selected...
Objective:To explore the value of indocyanine green（ICG） combined with methylene blue in identification sentinel lymph nodes（SLNs） patients diagnosed papillary thyroid microcarcinoma（PTMC）. Methods:Ninety were enrolled and randomized into group A B 45 each group. ICG injected A, only B. Blue-stained or fluorescent nodes observed using near-infrared fluorescence imaging systems defined as SLNs. After SLNs removed, central nodes（CLNs） dissection was completed both groups. The pathological data...
Objective To explore the clinical value of Delphian node (DN) metastasis in papillary thyroid cancer(PTC).Method In this study,86 cases unilateral PTC proved by frozen pathology and initially undergoing surgical treatment were enrolled to evaluate nodes its correlation with age,sex,tumor size,extra-thyroid extension central lateral compartment nodes.Results All patients underwent homolateral thyroidectomy plus contralateral subtotal thyroidectomy,central region Ⅲ Ⅳ lymphadenectomy.There no...
Abstract Background: AKT inhibitor was reported to be a potential treatment for drug-resistant tumors by reducing activity, and synergistic agent of ICIs. Afuresertib is an oral pan-AKT that has shown clinical efficacy in multiple tumors. The phase I part this study assessed the safety, tolerability, anti-tumor activity combination therapy LAE005 (PD-L1 antibody) plus afuresertib nab-paclitaxel advanced solid tumors, primarily TNBC. Methods: This multi-center, open-label, dose-escalation...
Objective To explore the rule of central region lymph nodes metastasis in differentiated thyroid carcinoma (DTC) and significance neck dissection surgical operation for DTC.Methods The clinical pathological data 122 109 patients (31 female 78 male) with DTC undergoing ( included) from Jan.2003 to Jun.2007 our hospital were analyzed retrospectively.According preoperative physical examination imaging analysis,patients divided into cervical cN + ) group no (cNO) compared respectively their...
Objective To investigate the exposure and protection of recurrent laryngeal nerve (RLN) in reoperation for thyroid diseases.Methods Clinical data 214 cases undergoing were retrospectively analyzed.The patients with a short interval between 2 operations or external-infiltrated cancer approached at lateral strap muscles leading edge sternocleidomastoid.RLNs exposed region superior mediastinum tracheoesophageal groove point where RLN enters to throat.RLNs lymph node metastasis beside enlarged...
Objective To discuss the prevention and treatment of complications modified radical mastectomy with nipple-areola complex (NAC) sparing. Methods The clinical data 124 breast cancer patients who had a NAC sparing from January 1998 to December 2008 were analyzed retrospectively. causes evaluated proposal was put forward. Results Of patients, 18 nipple necrosis (14.52%), 9 skin infections (7.26%), 7 subcutaneous hydrops(5.65%), 5 upper extremity lymphedema (4.03%), 3 chest muscle contracture...