A5052810353- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Ion Channels and Receptors
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Pregnancy and preeclampsia studies
- Neuroscience and Neural Engineering
- Pulmonary Hypertension Research and Treatments
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Muscle Physiology and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
Seoul National University
2015-2024
New Generation University College
2011-2024
Yanbian University Hospital
2015-2024
University of Manchester
2015-2023
Manchester Academic Health Science Centre
2022
Hubei University of Medicine
2018
Taihe Hospital
2018
University of Oxford
2004-2018
Lanzhou University
2013
John Radcliffe Hospital
2003-2012
Human atrial fibrillation (AF) has been associated with increased oxidative stress. In animal models, inhibition of reactive oxygen species prevents remodeling induced by rapid pacing, suggesting that stress may play an important role in the pathophysiology AF. NAD(P)H oxidase is a major source superoxide cardiovascular system; however, whether this enzyme contributes to AF remains be elucidated. We investigated sources production (using inhibitors and substrates range oxidases, RT-PCR,...
Stimulation of nitric oxide (NO) release from the coronary endothelium facilitates myocardial relaxation via a cGMP-dependent reduction in myofilament Ca2+ sensitivity. Recent evidence suggests that NO released by neuronal synthase (nNOS) myocardium can also hasten left ventricular relaxation; however, mechanism underlying these findings is uncertain. Here we show both (TR50) and rate [Ca2+]i transient decay (tau) are significantly prolonged field-stimulated or voltage-clamped myocytes...
Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca2+ sensitivity. Mouse models exhibit increased buffering and arrhythmias, we hypothesized these changes are primary effects of the mutations (independent compensatory changes) altered handling contribute to HCM pathogenesis via activation Ca2+-dependent signaling. Here, determined on intracellular signaling a model system possessing Ca2+-handling mechanisms contractile protein...
AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting regulatory γ2 subunit have been shown to cause essentially cardiac-restricted phenotype hypertrophy conduction disease, suggesting a specific role for this
Neutrophil to lymphocyte ratio (NLR) in peripheral blood is established correlate with the morbidity and mortality of heart disease patients. We aimed define severity inflammation by observing association NLR cardiac functions or myocardial damage parameters patients acute infarction.Data from 715 who underwent percutaneous coronary intervention (PCI) within 72 hours incidence 2016 were analysed retrospectively.The ranges 0.50 46 (medium ± SD, 2.76 2.96) positively correlated (NLR vs. CK-mB:...
Pre-eclampsia (PE) is a pregnancy disorder that related to an enhanced immune response. Immune cell characteristics such as neutrophil or monocyte lymphocyte ratios (NLR, MLR) are known be kidney and liver dysfunction in hypertensive patients. Here, we aimed analyze the correlations between NLR, MLR platelet ratio (PLR) liver, renal coagulation functional parameters impacts of these profiles prognostic significance PE patients.Pre-delivery hematological biochemical 320 first-time pregnant...
<ns4:p>Nitric oxide (NO) is an imperative regulator of the cardiovascular system and a critical mechanism in preventing pathogenesis progression diseased heart. The scenario bioavailable NO myocardium complex: 1) derived from both endogenous synthases (endothelial, neuronal, and/or inducible NOSs [eNOS, nNOS, iNOS]) exogenous sources (entero-salivary pathway) amount varies significantly; 2) are located at discrete compartments cardiac myocytes regulated by distinctive mechanisms under...
Abstract Mitochondrial dysfunction is a feature of type I and II diabetes, but there lack consistency between reports links to disease development. We aimed investigate if mitochondrial structure–function remodelling occurs in the early stages diabetes by employing mouse model (GENA348) Maturity Onset Diabetes Young, exhibiting hyperglycemia, not hyperinsulinemia, with mild left ventricular dysfunction. Employing 3-D electron microscopy (SBF-SEM) we determined that compared wild-type, WT,...
Abstract Obesity has been linked with the impairment of spatial memory and synaptic plasticity but molecular mechanisms remained unidentified. Since glutamatergic transmission NMDA receptor neural pathways in hippocampal dentate gyrus (DG) are essential learning memory, we aimed to investigate glutamate (Glu) signaling DG diet-induced obesity (DIO) rats. Spatial were assessed via Morris water maze (MWM) test on control (Ctr) DIO Extracellular concentration Glu was determined using vivo...
Neuronal nitric oxide synthase (NOS1 or nNOS) exerts negative inotropic and positive lusitropic effects through Ca(2+) handling processes in cardiac myocytes from healthy hearts. However, underlying mechanisms of NOS1 diseased hearts remain unclear. The present study aims to investigate this question angiotensin II (Ang II)-induced hypertensive rat (HP). Our results showed that the systolic function left ventricle (LV) was reduced diastolic unaltered (echocardiographic assessment) HP...
The role of constitutive nitric oxide (NO) production in the regulation beta-adrenergic and muscarinic responses remains controversial. Conflicting data left ventricular (LV) myocytes from eNOS knockout mice (eNOS-/-) have been ascribed to inconsistent experimental conditions (i.e., differences choice controls, age mice, myocytes' stimulation frequency, level stimulation); however, recent identification a neuronal-like NO synthase (nNOS) LV myocardium has raised possibility that this isoform...
The endothelial nitric oxide synthase (eNOS) has been implicated in the rapid (Frank–Starling) and slow (Anrep) cardiac response to stretch. Our work that of others have demonstrated a neuronal (nNOS) localized myocardium plays an important role regulation function calcium handling. However, effect nNOS on myocardial stretch yet be investigated. Recent evidence suggests stretch-induced release angiotensin II (Ang II) endothelin 1 (ET-1) stimulates superoxide production from NADPH oxidases...
The general consensus is that immune cells are exposed to physiological hypoxia in vivo (PhyO2, 2-5% P(O2)). However, functional studies of B hypoxic conditions sparse. Recently, we reported the expression mouse TASK-2, a member pH-sensitive two-pore domain K(+) channels with background activity. In this study, investigated response sustained PhyO2 (sustained [SH], 3% P(O2) for 24 h) WEHI-231 cells. SH induced voltage-independent conductance (SH-K(bg)) and hyperpolarized membrane potential....
Hypoxia-induced pulmonary vasoconstriction (HPV) is critical for matching of ventilation/perfusion in lungs. Although hypoxic inhibition K(+) channels has been a leading hypothesis depolarization arterial smooth muscle cells (PASMCs) under hypoxia, pharmacological does not induce significant contraction rat arteries. Because partial by thromboxane A(2) (TXA(2)) required induction HPV, we hypothesize that TXA(2) receptor (TP) stimulation might activate depolarizing nonselective cation (NSCs)....
Hypertension is critical risk factor of fatal cardiovascular diseases and multiple organ damage. Early detection hypertension even at pre-hypertension stage helpful in preventing the forthcoming complications. Electrocardiogram (ECG) has been attempted to observe changes electrical activities hearts hypertensive patients. To automate ECG assessment hypertension, an interpretable hybrid model proposed this paper. The framework consists one dimensional - Convolutional Neural Network...
LPSs are widely used to stimulate TLR4, but their effects on ion channels in immune cells poorly known. In THP-1 and human blood monocytes treated with LPS, inwardly rectifying K(+) channel current (IKir,LPS) newly emerged at 1 h, peaked 4 h (-119 ± 8.6 pA/pF), decayed afterward (-32 6.7 pA/pF 24 h). Whereas both the Kir2.1 Kir2.2 mRNAs proteins were observed, single-channel conductance (38 pS) of IKir,LPS small interfering RNA-induced knockdown commonly indicated than Kir2.1. LPS-induced...