A5007818052- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Redox biology and oxidative stress
- Anodic Oxide Films and Nanostructures
- S100 Proteins and Annexins
- RNA regulation and disease
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- RNA Research and Splicing
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Cardiac Arrhythmias and Treatments
- Conducting polymers and applications
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Adhesion Molecules Research
- Cardiac and Coronary Surgery Techniques
University of Oxford
2016-2025
John Radcliffe Hospital
2015-2025
British Heart Foundation
2020-2024
Swansea University
2017
Maastricht University
2011-2015
Universitätsklinikum des Saarlandes
2015
Athens State University
2013
University of Leeds
2013
National and Kapodistrian University of Athens
2010-2011
Hippocration General Hospital
2010
Background— Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin cross-talk between adipose tissue and vascular redox state patients atherosclerosis. Methods Results— The study included 677 undergoing coronary artery bypass graft surgery. Endothelial function was evaluated by flow-mediated dilation brachial vivo vasomotor studies saphenous vein segments ex vivo. Vascular superoxide (O 2 − ) endothelial nitric...
Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined effect diabetes on NADPH oxidase human vessels and explored mechanisms this interaction. Segments internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) thoracic were obtained from 386 patients undergoing coronary bypass surgery (127 diabetes). Type was strongly correlated hypoadiponectinemia increased oxidase–derived superoxide anions (O2˙−). The genetic variability...
An altered nitric oxide-redox balance has been implicated in the pathogenesis of atrial fibrillation (AF). Statins inhibit NOX2-NADPH oxidases and prevent postoperative AF but are less effective secondary prevention; mechanisms underlying these findings poorly understood.By using goat models pacing-induced or structural remodeling to atrioventricular block right samples from 130 patients undergoing cardiac surgery, we found that responsible for NO-redox imbalance differ between atria with...
Statins improve clinical outcome of patients with atherosclerosis, but their perioperative role in undergoing coronary artery bypass grafting (CABG) is unclear. We hypothesized that short-term treatment atorvastatin before CABG would the redox state saphenous vein grafts (SVGs), independently low-density lipoprotein cholesterol (LDL)-lowering.In a randomized, double-blind controlled trial, 42 statin-naïve elective received 40 mg/d or placebo for 3 days surgery. Circulating inflammatory...
Atrial fibrillation (AF) is a growing public health burden, and its treatment remains challenge. AF leads to electrical remodeling of the atria, which in turn promotes maintenance resistance treatment. Although has long been therapeutic target AF, causes remain poorly understood. We show that atrial-specific up-regulation microRNA-31 (miR-31) goat human depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay alters nNOS subcellular localization repressing dystrophin...
Heart failure with preserved ejection fraction (HFPEF) evolves the accumulation of risk factors. Relevant animal models to identify potential therapeutic targets and test novel therapies for HFPEF are missing. We induced hypertension hyperlipidemia in landrace pigs ( n = 8) by deoxycorticosteroneacetate (DOCA, 100 mg/kg, 90-day-release subcutaneous depot) a Western diet (WD) containing high amounts salt, fat, cholesterol, sugar 12 wk. Compared weight-matched controls 8), DOCA/WD-treated...
Atrial fibrillation (AF) leads to structural and neural remodeling in the atrium, which enhances AF complexity perpetuation. Renal denervation (RDN) can reduce renal whole-body sympathetic activity. Aim of this study was determine effect nervous system modulation by RDN on atrial arrhythmogenesis.Eighteen goats were instrumented with an endocardial pacemaker lead a burst pacemaker. Percutaneous catheter-based performed 8 (RDN-AF). Ten undergoing sham procedure served as control (SHAM-AF)....
Renal fibrosis is the common outcome in all progressive forms of chronic kidney disease. Unfortunately, pathogenesis renal remains largely unexplored, among which metabolic reprogramming plays an extremely crucial role evolution fibrosis. Ceria nanoparticles (CeNP-PEG) with strong ROS scavenging and anti-inflammatory activities have been applied for mitochondrial oxidative stress inflammatory diseases. The present study aims to determine whether CeNP-PEG has therapeutic value fibrosis.The...
Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthases (NOS). Oral BH4 supplementation preserves cardiac function in animal models disease; however, the mechanisms underlying these findings are not completely understood.To study effect myocardial transgenic overexpression rate-limiting enzyme biosynthesis, GTP cyclohydrolase 1 (GCH1), on NOS activity, function, and Ca2+ handling.GCH1overexpression significantly increased biopterins level left ventricular (LV) myocytes...
Background and aims: Renal damage in severe coronavirus disease 2019 (COVID-19) is highly associated with mortality. Finding relevant therapeutic candidates that can alleviate it crucial. Angiotensin-converting enzyme inhibitors (ACEIs) angiotensin-receptor blockers (ARBs) have been shown to be harmless COVID-19 patients, but remains elusive whether ACEIs/ARBs protective benefits them. We wished determine if had a effect on the renal COVID-19, investigate mechanism. Methods: used envelope...
Abstract The dysregulation of gene expression programs in the human atria during persistent atrial fibrillation (AF) is not completely understood. Here, we reanalyze bulk RNA-sequencing datasets from two studies ( N = 242) and identified 755 differentially expressed genes left appendages individuals with AF non-AF controls. We combined a appendage single-nucleus multi-omics dataset to assign specific cell types. found noncoding at IFNG locus LINC01479 , IFNG-AS1 ) strongly dysregulated...
Offspring of hypertensive pregnancies are at increased risk developing hypertension in adulthood. In the neonatal period they display endothelial cell dysfunction and altered microvascular development. MicroRNAs, as important cellular regulators, may play a role this early dysfunction. Therefore we identified differential microRNA patterns cells from offspring determined their postnatal vascular function. Studies were performed on human umbilical vein (HUVECs) samples 57 pregnancies....
Osteopenia and osteoporosis are among the most common metabolic bone diseases represent major public health problems, with sufferers having an increased fracture risk. Diabetes is one of contributing to osteopenia osteoporosis. However, mechanisms underlying diabetes-induced remain unclear. Bone reconstruction, including formation absorption, a dynamic process. Large-conductance Ca
In diabetic patients, heart failure with predominant left ventricular (LV) diastolic dysfunction is a common complication for which there no effective treatment. Oxidation of the NOS (nitric oxide synthase) cofactor tetrahydrobiopterin (BH4) and dysfunctional activity have been implicated in pathogenesis vascular cardiomyopathic phenotype.Using mice models human myocardial samples, we evaluated whether by mechanism increasing BH4 availability prevented or reversed LV induced diabetes.In...
AimsIn healthy hearts, the neuronal nitric oxide synthase (nNOS) is predominantly localized to sarcoplasmic reticulum (SR), where it regulates ryanodine receptor Ca2+ release channel (RyR2) and phospholamban (PLB) phosphorylation, a lesser extent sarcolemmal membrane inhibits L-type current (ICa). However, in failing impaired relaxation depressed inotropy are associated with larger proportion of nNOS being membrane. Whether there causal relationship between altered myocardial function...