A5005613099- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Minimally Invasive Surgical Techniques
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microscopic Colitis
- Tracheal and airway disorders
- Inflammatory Bowel Disease
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Neuroendocrine Tumor Research Advances
- Diagnosis and treatment of tuberculosis
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Diverticular Disease and Complications
- Medical Imaging and Pathology Studies
- Dysphagia Assessment and Management
- Celiac Disease Research and Management
University Hospital Schleswig-Holstein
2010-2019
University of Lübeck
2010-2019
Kiel University
2012-2019
Clinical Research Center Kiel
2012-2016
Homerton University Hospital
2005-2013
State of The Art
2004-2012
Schmerzklinik Kiel
2012
Optica
2012
Catalina Scientific (United States)
2012
Homerton University Hospital NHS Foundation Trust
2011
Despite improvements of diagnostic modalities differentiation between benign and malignant hilar strictures remains a challenge. Hilar neoplasia requires preoperative tissue diagnosis to avoid risk inappropriate extensive surgery. This is commonly attempted using various techniques at ERCP, which have variable sensitivity accuracy. We used endosonography-guided fine-needle aspiration (EUS-FNA) for the cholangiocarcinoma (HC).Prospective evaluation 44 patients (31 male, mean age: 59 yr) with...
Major leakage from an esophageal anastomosis is a life-threatening surgical complication. Endoscopically guided endoluminal vacuum therapy using polyurethane sponges new method for treating such leakage.Between June 2007 and 2009, five patients (mean age 68 years) who developed anastomotic after surgery were prospectively evaluated. After endoscopic diagnosis of major leakage, endoscopically positioned in the wound cavity anastomosis. Continuous suction was applied via drainage tubes fixed...
Phosphorylated alpha-synuclein (p-α-syn) containing Lewy bodies (LBs) and neurites (LNs) are neuropathological hallmarks of Parkinson’s disease (PD) in the central nervous system (CNS). Since they have been also demonstrated enteric (ENS) PD patients, aim study was to analyze p-α-syn positive aggregates intestinal gene expression. Submucosal rectal biopsies were obtained from patients with controls processed for dual-label-immunohistochemistry PGP 9.5. nerve fibers neuronal somata subjected...
Mediastinal lymphadenopathy (ML) is a cause for concern, especially in patients with previous malignancy. The investigation of choice thoracic CT variable sensitivity and specificity requiring tissue diagnosis. We used endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytodiagnosis ML without cause, distribution lesions, incidence second cancers were investigated.Linear echoendoscopes 22-gauge needles cytology EUS-FNA. A cytological diagnosis malignancy was accepted, histology or...
Resectional surgery offers a curative intent and survival benefit for patients with hilar cholangiocarcinoma, but is associated high morbidity. Since morphological imaging cannot solve differential diagnosis preoperatively, in order to exclude inappropriate this aggressive surgery, we evaluated the impact of functional using fluorodeoxyglucose positron emission tomography (FDG PET) detection cholangiocarcinoma its usefulness differentiation from benign Klatskin tumour-mimicking lesions....
Optical coherence tomography (OCT) is a new technique for high-resolution cross-sectional imaging using infrared light. It has over 10 times the resolution of currently available ultrasonography. Although in vitro studies have suggested its potential gastrointestinal imaging, vivo not been possible so far on account technical limitations.We describe here first clinical study OCT during routine endoscopy obtaining high images normal esophageal, gastric, and colonic mucosa. Portable equipment...
Natural orifice transluminal endoscopic surgery (NOTES) within the peritoneal cavity is rapidly evolving, using transgastric, transcolonic, or transvaginal access. There little experience with transesophageal NOTES access to mediastinum. This prospective long-term animal survival study was performed explore feasibility and safety of intrathoracic procedures including minor surgery.Nine pigs were used for acute (n = 2) up 6-week studies 7), followed by autopsy histological investigation. The...
Small bowel disease in the paediatric population is varied and to date has relied on indirect l modalities such as small follow-through with attendant radiation exposure. Wireless capsule endoscopy (WCE) potential provide a safer more effective means of investigating bowel. The aim our study was prospectively assess diagnostic yield WCE compared standard investigation children suspected disease.Twenty-eight consecutive patients, median age 12.5 y (range, 9.4-15.9) were investigated WCE. This...
Insertion of a percutaneous endoscopic gastrostomy (PEG) is standard care for many patients with oropharyngeal (ENT) and esophageal malignancies in order to ensure enteral feeding. The current pull-through insertion technique involves direct contact the tumor case reports have demonstrated presence metastases at sites. aim study was prospectively evaluate risk malignant cell seeding development abdominal wall after PEG placement.A total 50 consecutive ENT/esophageal tumors were included....
Summary Background Diagnosis of inflammatory bowel disease ( IBD ) is based on clinical presentation, colonoscopy and histology. Differentiation Crohn's CD ulcerative colitis UC can be difficult in some patients. Endoscopic ultrasound EUS provides high resolution images the gastrointestinal wall GI may an alternative to differentiate / . Aim layers patients with healthy controls HC for differential diagnosis a prospective, blinded study. Methods Consecutive , or underwent mid sigmoid colon...
Background and Study Aims: We studied the feasibility of endoscopic optical coherence tomography imaging in esophageal disorders, including Barrett's esophagus Barrett-related adenocarcinoma. Optical is a high-resolution cross-sectional technique with resolution almost 10 μm.