A5051206441- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Gut microbiota and health
- Blood Coagulation and Thrombosis Mechanisms
- Oral Health Pathology and Treatment
- Infective Endocarditis Diagnosis and Management
- Proteoglycans and glycosaminoglycans research
- HIV/AIDS oral health manifestations
Jagiellonian University
2019-2025
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil traps (NETs), are recognized a physiological microbicidal mechanism innate immunity. The formation NETs is also classified model cell death called NETosis. Despite intensive research on the in response pathogens, role specific bacteria-derived virulence factors this process, although postulated, still poorly understood. aim our study was determine gingipains,...
Neutrophil extracellular traps (NETs) are associated with diseases linked to aberrant coagulation. The blood clotting cascade involves a series of proteases, some which induce NET formation via yet unknown mechanism. We hypothesized that this signaling factor Xa (FXa) activation the protease-activated receptor 2 (PAR2). Our findings revealed NETs can be triggered in vitro by enzymatically active proteases and PAR2 agonists. Intravital microscopy liver vasculature both FXa infusion endogenous...
Vascular endothelial growth factor‐A (VEGF‐A) plays a pivotal role in inflammatory rheumatic diseases, including spondyloarthritis (SpA). Recently, we have demonstrated that the expression of VEGF‐A human classical monocytes is positively associated with number swollen and painful joints SpA patients. Therefore, tested whether anti‐VEGF‐A therapy can affect hallmarks SKG mouse model. When initiated at disease onset, administration monoclonal antibodies (mAbs) significantly reduced objective...
Periodontitis is a highly prevalent disease caused by accumulation of bacterial biofilm. Periodontal pathogens use number virulence strategies that are under intensive study to find optimal therapeutic approaches against bone loss.
Background Three-dimensional (3D) tissue models bridge the gap between conventional two-dimensional cell cultures and animal models. The aim of this study was to develop an organotypic 3D gingival (OTG) model provide a tool investigate bacterial viral pathogens in periodontitis.
Abstract Chronic periodontitis (CP) is an inflammatory disease of the tooth supporting tissue developed in response to formation dysbiotic biofilm on subgingival surface. Although exacerbated inflammation leads alveolar bone destruction and may cause loss molecular basis CP initiation progression remains elusive. The control over reaction homeostasis can be efficiently restored by negative regulators TLRs signaling pathways, such as MCPIP-1, which constitutively expressed gingival...