A5103043563- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- MicroRNA in disease regulation
- Regulation of Appetite and Obesity
- Frailty in Older Adults
- Thyroid Disorders and Treatments
- Vitamin D Research Studies
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Erythrocyte Function and Pathophysiology
- Parathyroid Disorders and Treatments
- Sirtuins and Resveratrol in Medicine
- Hormonal and reproductive studies
- Stress Responses and Cortisol
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Ophthalmology and Eye Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
Mossakowski Medical Research Institute, Polish Academy of Sciences
2007-2025
Polish Academy of Sciences
2007-2024
Wojskowy Instytut Medyczny
2006
Düsseldorf University Hospital
2005
Heinrich Heine University Düsseldorf
2005
Medizinische Hochschule Hannover
1986
In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years older, we investigated whether serum levels two proinflammatory factors, interleukin-6 (IL-6) C-reactive protein (CRP), were associated with physical cognitive performance, could predict mortality in successfully aging elderly.IL-6 CRP systematically increased an age-dependent manner entire study...
Impaired thermogenesis can promote obesity. Therefore, the aim of this study was to investigate whether expression thermogenesis-related genes is altered in adipose tissues obese individuals and excessive methylation their promoters involved phenomenon. The encoding β adrenergic receptors (ADRBs), thyroid hormone (THRs), 5’-iodothyronine deiodinases (DIOs), uncoupling proteins (UCPs) measured by real-time PCR visceral subcutaneous 58 (BMI >40 kg/m2) 50 slim 20-24.9 individuals. status these...
Both obesity and weight loss may cause molecular changes in adipose tissue. This study aimed to characterize tissue miRNome order identify pathways affected by changes. Next generation sequencing (NGS) was applied microRNAs (miRNAs) differentially expressed 47 samples of visceral (VAT) subcutaneous (SAT) tissues from normal-weight (N), obese (O) after surgery-induced (PO) individuals. Subsequently miRNA expression validated real-time PCR 197 bioinformatics analysis performed obesity-related...
Excess adiposity is associated with chronic inflammation, which takes part in the development of obesity-related complications. The aim this study was to establish whether subcutaneous (SAT) or visceral (VAT) adipose tissue plays a major role synthesis pro-inflammatory cytokines. Concentrations interleukins (IL): 1β, 6, 8 and 15 were measured at protein level by an ELISA-based method on mRNA real-time PCR VAT SAT samples obtained from 49 obese (BMI > 40 kg/m2) 16 normal-weight 20–24.9...
The interplay between adiponectin and resistin, the two adipokines of opposite effects, may determine metabolic profile obese individuals development obesity-related complications. current study was conducted to assess how adiponectin/resistin in sera adipose tissues influence normal-weight subjects.Concentrations resistin were measured on protein level by immunoassay visceral subcutaneous from 50 (body mass index > 40 kg/m2) 28 20-24.9 individuals. Simultaneously expression ADIPOQ RETN...
Clinical and biochemical predictors of extreme longevity would be useful in geriatric practice but have still not been clearly defined. To identify the best nongenetic survival centenarians, we examined 340 individuals aged 100+ years. A detailed questionnaire was completed, comprehensive assessment blood analyses were performed. Survival study participants checked annually over period 10 In univariate Cox proportional hazards model, a longer centenarians correlated with higher adjusted...
Background: Given the role that vitamin D (VD) plays in regulation of inflammatory activity adipocytes, we aimed to assess whether obesity changes expression VD-related genes adipose tissue and, if so, investigate this phenomenon depends on microRNA interference and how it may influence local milieu. Methods: The encoding VD 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) receptor (VDR), selected interleukins microRNAs was evaluated by real-time PCR visceral (VAT) subcutaneous (SAT)...
Frailty is a major geriatric problem leading to an increased risk of disability and death. Prevention, identification, treatment frailty are important challenges in gerontology public health. The study aimed estimate the prevalence phenotype (FP) among oldest-old Polish Caucasians investigate relationship between FP mortality. Baseline data were collected from 289 long-lived individuals, including 87 centenarians 202 subjects aged 94–99. Mortality was obtained population registers over...
<title>Abstract</title> Adipose tissue-derived microRNAs are recognized as key players in the development of obesity-related complications. The aim this study was to investigate whether expression genes critical for both insulin sensitivity and neuronal metabolism (<italic>APP</italic>, <italic>SOCS3</italic>, <italic>PTPN1</italic>, <italic>PTPN2</italic>) is altered by microRNA interference adipose tissue obese patients, predisposing them metabolic inflammation possibly cognitive decline....
Estrogen affects adipose tissue function. Therefore, this study aimed at assessing changes in the transcriptional activity of estrogen receptor (ER) α and β genes (ESR1 ESR2, respectively) tissues obese individuals before after weight loss verifying whether epigenetic mechanisms were involved phenomenon. ESR1 ESR2 mRNA miRNA levels evaluated using real-time PCR visceral (VAT) subcutaneous (SAT) 78 (BMI > 40 kg/m2) 31 normal-weight = 20−24.9 19 SAT samples from post-bariatric patients....
Aim Aging is usually associated with hyperleptinemia and leptin resistance, both increasing the risk of age‐related diseases. It was relevant to establish if healthily aging, non‐obese individuals develop changes in leptin, soluble receptor ( OB ‐ R e), free index FLI ), methylation gene LEPR ) promoter, expression long b) short a) isoforms. Methods We analyzed these parameters 38 young (aged 26.8 ± 3.6 years), 37 elderly 64.7 3.1 years) 39 long‐lived 94.2 3.7 healthy, Polish Caucasians....
The similarity of the clinical picture metabolic syndrome and hypercortisolemia supports hypothesis that obesity may be associated with impaired expression genes related to cortisol action metabolism in adipose tissue. encoding glucocorticoid receptor alpha (GR), metabolizing enzymes (HSD11B1, HSD11B2, H6PDH), adipokines, as well selected microRNAs, was measured by real-time PCR tissue from 75 patients obesity, 19 following surgery, 25 normal-weight subjects. Cortisol levels were analyzed...
The advanced glycosylation end-product receptor (AGER) is involved in the development of metabolic inflammation and related complications type 2 diabetes mellitus (T2DM). Tissue expression AGER gene regulated by epigenetic mediators, including a long non-coding RNA AGER-1 (lncAGER-1). This study aimed to investigate whether human obesity T2DM are associated with an altered lncAGER-1 adipose tissue and, if so, these changes affect local inflammatory milieu. genes encoding AGER, selected...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)