A5051319556- Animal testing and alternatives
- Pharmacological Effects of Natural Compounds
- Biosimilars and Bioanalytical Methods
- Immunotoxicology and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Neurological Disorders and Treatments
- Medicinal Plants and Bioactive Compounds
- Clinical Laboratory Practices and Quality Control
- Coenzyme Q10 studies and effects
- Computational Drug Discovery Methods
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Neurotoxicity Research
- Human Health and Disease
- Antimicrobial Peptides and Activities
- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Chemical Reactions and Isotopes
- Biochemical effects in animals
- Phytochemistry and Bioactivity Studies
- Yersinia bacterium, plague, ectoparasites research
- Seaweed-derived Bioactive Compounds
- Electrolyte and hormonal disorders
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Pediatric health and respiratory diseases
North-Western State Medical University named after I.I. Mechnikov
2012-2024
CS Diagnostics
2023
ME Association
2020-2022
Saint - Petersburg State Chemical Pharmaceutical Academy
2008-2021
Home Depot (United States)
2020-2021
St. Petersburg Department of Steklov Institute of Mathematics
2021
Udmurt State University
2018
First Pavlov State Medical University of St. Petersburg
2018
Institute of Experimental Medicine
2017
Northwestern State University
2012
This study was undertaken to evaluate possible antiallergic effects of an extract pigments from green sea urchin (<i>Strongylocentrotus droebachiensis</i>) shells. Effects were studied on animal models – guinea pig ileum contraction, rabbit eyes allergic conjunctivitis, and local skin irritation. The significantly reduced, in a dose-dependent manner, the histamine-induced contractions isolated with ID<sub>50</sub> = 1.2 µg/mL (in equivalents spinochrome B), had inhibitory effect model ocular...
One of the major obstacles to effective translational medicine is challenge translating animal research results into clinical studies. Scientific literature mainly addresses selection drug dose at initiation trials (Phase 1). Appropriate doses also essential for preclinical toxicology and pharmacology Some basic principles that are used when dosages from models humans applicable justification planning conducting The paper provides an overview main methods can be in studies, e.g....
Lithium salts are known to treat bipolar disorder. Their high potential as neuroprotective agents in cerebral ischemia determines relevance for preclinical studies the registration of new drugs based on them. Aim study was investigate toxic properties and local tolerability with an assessment toxicokinetics developed lithium chloride preparation injection dwarf pigs repeated intravenous administration. Material methods . (solution, administration 4.2 %) has been administered minipigs...
INTRODUCTION. Currently, the Eurasian Economic Union (EAEU) lacks guidelines for documenting preclinical studies. At same time, proper registration of raw data is necessary to confirm quality results obtained. AIM. This study aimed at introducing a documentation procedure studies that would cover documents from initial application final report and provide transfer marketing authorisation dossier. MATERIALS AND METHODS. The authors opted information analysis as method research. All...
Relevance . During 2021 and early 2022, the prevalence of COVID-19 in child population was 9.5%, frequency hospitalizations children adolescents increased, fatal outcomes began to be recorded. And 2022–2023, proportion infected with increased 18%. At same time, vaccination remains most effective way protect against infection. Studying safety vaccines for prevention coronavirus infection is an urgent task. Objective study To a vaccine new immature animals. Materials methods The conducted on...
INTRODUCTION . Quality by design (QbD) is a systematic approach to pharmaceutical development that begins with predefined objectives and emphasises product process understanding control, based on sound science quality risk management. The QbD facilitates the production of medicinal products target characteristics profiles. There are currently no specific guidelines for application principles individual dosage forms. AIM This study aimed evaluate possibility propose an algorithm using at...
Introduction. The prevalence of new coronavirus infection (COVID-19) in 2021-2022 the pediatric population was 9.5%, and fatal outcomes began to be recorded. In 2022–2023, proportion children infected with COVID-19 increased 18%. Developing a vaccine for is an urgent task. aim study explore effect on parameters general biochemical blood tests immature rats. Materials methods. performed 112 rats (60 females, 52 males) Wistar line. Animals were randomized into groups that received CoviVac at...
The majority of seasonal influenza vaccines are trivalent, containing two A virus strains (H1N1 and H3N2) one B strain. co-circulation distinct lineages viruses can lead to mismatch between the strain recommended for trivalent vaccine circulating virus. This has led some manufacturers produce quadrivalent from each lineage in addition H1N1 H3N2 strains. However, it is also important know whether a single provide cross-protectivity against antigenically lineage. aim this study was assess...
Introduction. Pharmaceutical development of an innovative highly effective and competitive drug is a long expensive process, the result which quite difficult to predict in advance. To speed up entry new treatment reduce developer's material costs, it advisable include preclinical experiments process creating drug. Text. The purpose this work create justified approach implementation laboratory pharmaceutical involving vivo studies. inclusion studies will eliminate negative impact factors on...
Context: Potentilla alba L. (Rosaceae) rhizomes have anti-inflammatory, antioxidant, and adaptogenic effects are used for the treatment of diarrhea intestinal colic. However, data concerning central nervous system activities P. fragmentary.Objectives: To determine effect oral administration dried extract on swimming endurance, light/dark exploration, open-field tests mice.Materials methods: The mice were orally administered Rhodiola rosea (RR group); dry at doses 12, 36, or 72 mg/kg (groups:...
The lipids from gonads and polyhydroxynaphthoquinone pigments body walls of sea urchins are intensively studied. However, little is known about the wall (BW) lipids. Ethanol extract (55 °C) contained equal amounts saturated (SaFA) monounsaturated fatty acids (MUFA) representing 60% total acids, with myristic, palmitic eicosenoic as major SaFAs MUFAs, respectively. Non-methylene-interrupted dienes (13%) were composed eicosadienoic docosadienoic acids. Long-chain polyunsaturated (LC-PUFA)...