A5102849296- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- vaccines and immunoinformatics approaches
- Trypanosoma species research and implications
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Hepatitis C virus research
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Isotope Analysis in Ecology
- Lung Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Antibiotic Resistance in Bacteria
- Genomics and Chromatin Dynamics
- Congenital heart defects research
- COVID-19 Clinical Research Studies
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
National Institute of Biological Sciences, Beijing
2024-2025
Tsinghua University
2025
Sun Yat-sen University
2012-2025
Sun Yat-sen University Cancer Center
2012-2025
China University of Petroleum, East China
2025
Origin Quantum Computing Technology Company (China)
2024
Chinese Academy of Sciences
2004-2023
Jiangxi University of Traditional Chinese Medicine
2010-2023
Center for Excellence in Molecular Cell Science
2005-2023
Weatherford College
2023
Host cellular receptors play key roles in the determination of virus tropism and pathogenesis. However, little is known about SARS-CoV-2 host with exception ACE2. Furthermore, ACE2 alone cannot explain multi-organ nor clinical differences between SARS-CoV, suggesting involvement other receptor(s). Here, we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction capsid spike (S) protein. Twelve proteins, including ACE2, ASGR1, KREMEN1, were...
The WRKY transcription factor family plays significant roles in biotic and abiotic stress responses, which has been associated with various biological processes higher plants. However, very little is known regarding the structure function of genes maize.
Human MRG15 is a transcription factor that plays vital role in embryonic development, cell proliferation and cellular senescence. It comprises putative chromo domain the N-terminal part has been shown to participate chromatin remodeling regulation. We report here crystal structure of human at 2.2 Å resolution. The consists β-barrel long α-helix assumes more similar Drosophila MOF barrel than typical HP1/Pc domains. core contains hydrophobic pocket formed by three conserved aromatic residues...
Nestin is a molecular marker for neural progenitor cells. Rat and human nestin genes possess central nervous system-specific enhancer within their second introns. However, the transcription factors that bind to have not been fully elucidated. Here, we show intron of mouse gene sufficient drive reporter expression in developing system. The core sequence this localizes 3' 320-bp region. cis-elements Sox POU family hormone-responsive element are essential during embryonic carcinoma P19 cell...
SUMMARY Host cellular receptors are key determinants of virus tropism and pathogenesis. Virus utilizes multiple for attachment, entry, or specific host responses. However, other than ACE2, little is known about SARS-CoV-2 receptors. Furthermore, ACE2 cannot easily interpret the multi-organ tropisms nor clinical differences between SARS-CoV. To identify cell involved in interactions, we performed genomic receptor profiling to screen almost all human membrane proteins, with capsid spike (S)...
Abstract 8-Oxo-7,8-dihydro-2′-deoxyguanosine (OG), one of the most common oxidative DNA damages, causes genome instability and is associated with cancer, neurological diseases aging. In addition, OG its repair intermediates can regulate gene transcription, thus play a role in sensing cellular stress. However, lack methods to precisely map has hindered study biological roles. Here, we developed single-nucleotide resolution OG-sequencing method, named CLAPS-seq (Chemical Labeling And...
Mammalian lung development consists of a series precisely choreographed events that drive the progression from simple buds to elaborately branched organ fulfills vital function gas exchange. Strict transcriptional control is essential for development. Among large number transcription factors encoded in mouse genome, only small portion them are known be expressed and developing lung. Thus systematic investigation warranted.
Human respiratory syncytial virus can cause severe infections, which is recognized as one of the highest priority pathogen by World Health Organization. Although vaccines play an important role in disease prevention and transmission, wild-type usually prone to immune escape due high mutation rate biological macromolecular proteins. Therefore, designing a broad-spectrum hRSV vaccine essential provide extensive protection against multiple viral variants. Here, with consensus sequence approach,...
Stage 1 rectal neuroendocrine tumors (NETs) are best treated with endoscopic submucosal dissection (ESD) or transanal microsurgery (TEM) for local resection. To investigate the safety and efficacy of ESD TEM resection stage NETs. This retrospective observational analysis included patients clinical NETs (cT1N0M0, less than 20 mm) who underwent TEM. The groups were matched to ensure that they had comparable lesion sizes, locations, pathological grades. We assessed differences between in terms...
Fractured-vuggy marine carbonate reservoirs, as an unconventional energy resource, hold significant potential for exploration and development. In this study, the Manshen block of Furman oilfield in Tarim Basin, China, was selected research object. A systematic investigation conducted on types reservoir bodies, production characteristics, both static dynamic connectivity. Static connectivity analysis performed using heat diffusion equation multi-source field method. Dynamic evaluation carried...
Abstract We propose a novel method for frequency trimming of superconducting qubits via RF-biased ICP annealing. Junction resistance increases with RF bias power, achieving maximum increase approximately 40% under O2 plasma and up to 180% Ar conditions. Specifically, oxygen-based annealing notably improves qubit coherence, extending both relaxation coherence times. TEM analysis indicates that the observed in junction corresponds structural changes barrier thickening. Our results demonstrate...
Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved human 2q23.1 microdeletion syndrome. To investigate physiological role Mbd5, we generated knockout mice. Mbd5-deficient mice showed growth retardation, wasting pre-weaning lethality. observed retardation was associated with impairment...
Abstract We investigated a new chemoradiotherapy (CRT) regimen for locoregionally advanced nasopharyngeal carcinoma (NPC). A total of 240 patients were randomly assigned to three different CRT regimens: sequential [1 cycle chemotherapy + Phase I radiotherapy (RT) 1 II RT 2 cycles chemotherapy] with cisplatin–gemcitabine (GC) (800 mg/m gemcitabine on Days and 8 20 cisplatin 1–5, every 4 weeks) (sGC‐RT); cisplatin–fluorouracil (PF) (20 DDP 500 5‐FU (sPF‐RT) cisplatin‐based concurrent plus...
Atherosclerosis‑induced cardiovascular diseases (CVDs) are accompanied by substantial morbidity and mortality. The loss injury of endothelial cells is the primary cause atherosclerosis. Rosuvastatin an alternative agent used to reduce risk disease. Subsequently, present study aimed investigate protective effects rosuvastatin on oxidized‑low‑density lipoprotein (ox‑LDL)‑induced human umbilical vein cell (HUVEC) injury. viability ox‑LDL‑cultured HUVECs with or without (0.01, 0.1 1 µmol/l)...