A5035758532- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Dermatology and Skin Diseases
- Hydrogels: synthesis, properties, applications
- Lipid Membrane Structure and Behavior
- Drug Solubulity and Delivery Systems
- Contact Dermatitis and Allergies
- Bee Products Chemical Analysis
- Magnetic Properties and Synthesis of Ferrites
- Virus-based gene therapy research
- Essential Oils and Antimicrobial Activity
- Analytical Methods in Pharmaceuticals
- Protein purification and stability
- Microbial Inactivation Methods
- Supramolecular Self-Assembly in Materials
- Alzheimer's disease research and treatments
- Toxin Mechanisms and Immunotoxins
- Iron oxide chemistry and applications
- Multiferroics and related materials
- Nerve injury and regeneration
- biodegradable polymer synthesis and properties
- Transgenic Plants and Applications
North Dakota State University
2016-2025
Dakota State University
2020-2025
Sri Guru Granth Sahib World University
2024
Brown University
2024
Sawai ManSingh Medical College and Hospital
1994-2022
Mayo Clinic in Florida
2020
Indian Institute of Vegetable Research
2020
Indian Institute of Pulses Research
2015-2018
University of California, San Francisco
1993-2015
Indian Institute of Technology Roorkee
2005-2015
Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Anti-cancer chemotherapeutic agents have limited access into the due presence of blood barrier (BBB). In this study, we designed dual functionalized liposomal delivery system, surface modified transferrin (Tf) for receptor mediated transcytosis and cell penetrating peptide-penetratin (Pen) enhanced penetration. We loaded doxorubicin erlotinib liposomes enhance their translocation across BBB...
Targeting gene-based therapeutics to the brain is a strategy actively sought treat Alzheimer's disease (AD). Recent findings discovered role of apolipoprotein E (ApoE) isoforms in clearance toxic amyloid beta proteins from brain. ApoE2 isoform beneficial for preventing AD development, whereas ApoE4 major contributing factor disease. In this paper, we demonstrated efficient brain-targeted delivery encoding plasmid DNA (pApoE2) using glucose transporter-1 (glut-1) targeted liposomes. Liposomes...
Alzheimer's disease (AD), the most common cause of dementia, inflicts enormous suffering to patients and their family members. It is third deadliest disease, affecting 46.8 million people worldwide. Brain-derived neurotrophic factor (BDNF) involved in development, maintenance, plasticity central nervous system. This crucial protein significantly reduced AD leading neuronal death. In this study, we demonstrate targeted delivery BDNF gene brain using liposome nanoparticles. These liposomes...
To develop a safe, effective, and biocompatible gene delivery vector, series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization AGC polymers was performed NMR elemental analysis. demonstrated excellent blood compatibility cell viability, as evaluated hemolysis MTT assay, respectively. could effectively bind condense plasmid DNA (pDNA) to form polyplexes in the size range 161–263 nm possessed net...