A5031582028- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Leptospirosis research and findings
- Vector-borne infectious diseases
- Insect and Pesticide Research
- Intellectual Capital and Performance Analysis
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Bone health and treatments
- Catalytic C–H Functionalization Methods
- Plant-derived Lignans Synthesis and Bioactivity
- Business and Management Studies
- Synthesis and biological activity
- Information Science and Libraries
- Organophosphorus compounds synthesis
- Genomics, phytochemicals, and oxidative stress
Ezequiel Dias Foundation
2018-2025
Centro de Desenvolvimento da Tecnologia Nuclear
2011-2015
National Nuclear Energy Commission
2012
Universidade Federal de Minas Gerais
2010-2012
Fundação Oswaldo Cruz
2006-2008
Universidade de São Paulo
2005
The efficacy of conjunctival swab (CS) as a sampling method for visceral leishmaniasis (VL) diagnosis by PCR asymptomatic dogs was evaluated. CS compared to blood samples (B) and skin biopsies (SB), two less invasive potentially useful massive screening dogs. Thirty dogs, with serological parasitological positive tests, were used. analyzed methods: kDNA PCR-hybridization ITS-1 nPCR. DNA sample volume used 1.0 microL 10.0 respectively. Using the able detected parasite in 24/30 (80%) using...
Background We evaluated kDNA PCR/hybridization and quantitative real-time PCR (qPCR) targeting the gene of DNA polymerase Leishmania infantum for CVL diagnosis assessment parasite load in clinical samples obtained invasively non-invasively. Methodology/Principal Findings Eighty naturally infected dogs from an endemic urban area Brazil were used. Animals divided into two groups based on presence or absence sings. Skin biopsies, bone marrow, blood conjunctival swabs collected submitted to L....
PHARMACOLOGICAL APPLICATIONS.Bisphosphonates are drugs that have been widely used in different bone diseases, and recently successfully against many parasites.Various synthetic routes to prepare types of bisphosphonates described, with distinct potency pharmacological activity.A number analytical techniques currently being analyze these drugs; among these, the high performance liquid chromatography (HPLC), systems detection, is worth highlighting.However, development more sensitive methods...
TRYPANOTHIONE REDUCTASE INHIBITORS.Trypanosoma cruzi is a protozoan parasite that causes severe disease (Chagas'disease) in Central and South America.The currently available chemotherapeutic agents against this are still inadequate.The enzyme trypanothione reductase (TR) considered validated molecular target for the development of new drugs parasite.In regard, series arylfurans based on 2,5-bis-(4-acetamidophenyl)furan was synthesized tested their vitro inhibitory activity TR.Molecular...
The polymerase chain reaction (PCR) has been shown to provide a rapid and sensitive technique for Leishmania detection. aim of this study was evaluate the noninvasive conjunctival swabs (CS) as sampling method molecular screening visceral leishmaniasis (VL) in group 42 police dogs, all them vaccinated against VL, compare results with those obtained by serological tests. assays were performed independently three laboratories. Laboratories 1 2 private laboratories laboratory 3 National...
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O presente artigo tem por objetivo construir um diagnóstico da propriedade intelectual produzida pelos Institutos de Ciência e Tecnologia (ICT), vinculados à Rede Mineira Propriedade Intelectual (RMPI), no Estado Minas Gerais. Buscou-se mapear os depósitos realizados pelas ICTs, junto ao Instituto Nacional Industrial (INPI), apresentar a produção dessas instituições, além identificar tipos Propriedades Intelectuais mais recorrentes Estado. Serão descritas frequência das ocorrências dos...
Visceral leishmaniasis (VL) is a vector-borne disease that caused by the protozoan Leishmania infantum and transmitted to humans other mammals through bites of infected female sandflies. VL has been prevalent in Minas Gerais, Brazil, since 1940s. As vector completes its reproductive cycle soil with organic matter, association between occurrence unimproved solid waste disposal sites investigated. Thus, this study, we analyzed relationship conditions, inadequacies disposal, collection rates...