A5015273113- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Smoking Behavior and Cessation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Pharmaceutical Economics and Policy
- Celiac Disease Research and Management
- Diabetes Management and Research
- Health disparities and outcomes
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Biosimilars and Bioanalytical Methods
- Atherosclerosis and Cardiovascular Diseases
- Physical Activity and Health
- Breastfeeding Practices and Influences
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Promotion and Cardiovascular Prevention
- Eosinophilic Esophagitis
- Acute Myocardial Infarction Research
- Diet and metabolism studies
- Obesity and Health Practices
- Pneumonia and Respiratory Infections
- Cardiovascular Health and Risk Factors
Amgen (United States)
2022-2025
Amgen (United Kingdom)
2021-2024
Target (United States)
2023-2024
AbbVie (United States)
2024
University of Alabama at Birmingham
2023
Leicester General Hospital
2016-2022
University of Leicester
2016-2022
EVRAZ (United Kingdom)
2018-2021
Diagnostics for the Real World (United Kingdom)
2019
Nottingham City Hospital
2013-2018
Whether a healthy lifestyle impacts longevity in the presence of multimorbidity is unclear. We investigated associations between and life expectancy people with without multimorbidity.A total 480,940 middle-aged adults (median age 58 years [range 38-73], 46% male, 95% white) were analysed UK Biobank; this longitudinal study collected data 2006 2010, participants followed up until 2016. extracted 36 chronic conditions defined as 2 or more conditions. Four factors, based on national...
Multimorbidity is an emerging public health priority. Physical activity (PA) recommended as one of the main lifestyle behaviours, yet benefits PA for people with multimorbidity are unclear. We assessed on mortality and life expectancy in without multimorbidity. Using UK Biobank dataset, we extracted data 36 chronic conditions defined (a) 2 or more conditions, (b) combined self-reported overall health, (c) top-10 most common comorbidities. Leisure-time (LTPA) total (TPA) were measured by...
To estimate the risk of acute myocardial infarction (AMI) or stroke in adults with non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH).Matched cohort study.Population based, electronic primary healthcare databases before 31 December 2015 from four European countries: Italy (n=1 542 672), Netherlands (n=2 225 925), Spain (n=5 488 397), and UK (n=12 695 046).120 795 a recorded diagnosis NAFLD NASH no other diseases, matched at time (index date) by age, sex, practice site, visit,...
Objectives Assess the longitudinal association between polypharmacy and falls examine differences in this by different thresholds for definitions a nationally representative sample of adults aged over 60 years from England. Design Longitudinal cohort study. Setting The English Study Ageing waves 6 7. Participants 5213 or older. Main outcome measures Rates, incidence rate ratio (IRR) 95% CI people with without polypharmacy. Results A total participants contributed 10 502 person-years...
To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, cancer mortality. A total 230 670 women 190 057 men free from prevalent cardiovascular disease were included UK Biobank. Usual was self-defined as slow, steady/average or brisk. Handgrip assessed by dynamometer. Cox-proportional hazard models adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, television viewing time....
Multimorbidity has become one of the main challenges in recent years for patients, health care providers and systems globally. However, literature describing burden multimorbidity elderly population, especially longitudinal trends is very limited. Physical activity recommended as lifestyle changes prevention management multiple chronic diseases worldwide; however, evidence on its association with remains inconclusive. Therefore, we aimed to assess between physical a nationally representative...
Evidence on the role of lifestyle factors in relation to multimorbidity, especially elderly populations, is scarce. We assessed association between five and incident multimorbidity (presence ≥2 chronic conditions) an English cohort aged ≥50 years. used data from waves 4, 5, 6 Longitudinal Study Ageing. Data smoking, alcohol consumption, physical activity, fruit vegetable body mass index were extracted combined generate a sum unhealthy for each individual. examined whether these individually...
Background and aimsVariability in low-density lipoprotein-cholesterol (LDL-C) level control at a population is associated with poor cardiovascular outcomes. Limited data exist on LDL-C variability or long-term persistence the monoclonal antibody evolocumab routine clinical practice. Using from HEYMANS registry, this analysis aimed to assess discontinuation over 30 months of treatment evaluate reductions during study period.MethodsHEYMANS was prospective registry adults initiating practice 12...
Abstract Aims To describe the characteristics of patients receiving evolocumab in clinical practice across 12 European countries and simulate association between low-density lipoprotein cholesterol (LDL-C) reduction cardiovascular (CV) risk reduction. Methods results The hyperlipidaemic at initiation treatment patterns study—HEYMANS (n = 1952) is a prospective registry ≥18 years old who initiated from 1 August 2015 onwards. Mean (standard deviation) age was 60 (10.8), 85% had prior CV event,...
Conflicting findings and knowledge gaps exist regarding links between anemia, physical activity, health-related quality of life (HRQOL), chronic kidney disease (CKD) progression, mortality in moderate-to-advanced CKD. Using the CKD Outcomes Practice Patterns Study, we report associations hemoglobin (Hgb) with HRQOL Hgb activity progression stage 3-5 nondialysis (ND)-CKD patients.Prospectively collected data were analyzed from 2,121 ND-CKD patients, aged ≥18 years, at 43 nephrologist-run US...
Studies have associated infertility with celiac disease. However, these included small numbers of women attending specialist services and subsequently screened for disease, therefore may not been representative the general population. We performed a large population-based study disease in from United Kingdom.We identified 2,426,225 prospective UK primary care records between 1990 2013 during their child-bearing years The Health Improvement Network database. estimated age-specific rates new...
Nicotine replacement therapy (NRT) is now being used as a smoking cessation aid during pregnancy, although little known about fetal safety. We assessed the relationship between early pregnancy exposure to NRT or with major congenital anomalies (MCA) in offspring.We studied 192,498 children born United Kingdom 2001 and 2012 linked mother-child primary care records. The absolute risks of MCAs group (women prescribed first trimester 1 month before conception [and therefore likely consumed...
Whether and to what extent leisure-time physical activity at the recommended levels of 150-min moderate is associated with survival in people cardiometabolic multimorbidity depression unknown.UK Biobank participants were classified into groups: (i) no disease; (ii) diabetes; (iii) cardiovascular disease (CVD); (iv) depression; (v) diabetes CVD; (vi) (vii) CVD (viii) diabetes, depression. Leisure-time was categorized as active (meeting recommendations) or inactive. Survival models applied...
In the context of increasing prevalence diabetes in elderly people with multimorbidity, intensive glucose control may increase risk severe hypoglycaemia, potentially leading to death. While rising trends hypoglycaemia rates have been reported some European, North American and Asian countries, global burden hypoglycaemia-related mortality is unknown. We aimed investigate differences mortality.We used WHO database extract information on death certificates reporting or as underlying cause...
Rationale & ObjectivePrevious studies of inflammation and anemia management in hemodialysis (HD) patients may be biased due to patient differences. We used a self-matched longitudinal design test whether new inflammation, defined as an acute increase C-reactive protein (CRP) level, reduces hemoglobin response erythropoiesis-stimulating agent (ESA) treatment.Study DesignSelf-matched design.Setting Participants3,568 events, CRP level > 10 mg/L following 3-month period with ≤ 5 mg/L, were...
Licensing arrangements for nicotine replacement therapy (NRT) in the UK were broadened 2005 to allow prescribing pregnant smokers. However, estimates of NRT females are currently lacking.To assess trends around pregnancy, and variation by maternal characteristics.Population-based descriptive study using pregnancy data from The Health Improvement Network primary care database, 2001-2012.NRT prescriptions identified during 9 months before after. Annual prevalence was calculated. Logistic...
STUDY QUESTIONWhat are the age-specific incident rates of clinically recorded fertility problems in women aged 15–49 years and how do they vary by socioeconomic group geographic area.