- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Neonatal Health and Biochemistry
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Bone and Joint Diseases
- Venous Thromboembolism Diagnosis and Management
- Hematopoietic Stem Cell Transplantation
- Blood properties and coagulation
- Chronic Lymphocytic Leukemia Research
- Pharmacogenetics and Drug Metabolism
- Blood disorders and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related gene regulation
Sultan Qaboos University Hospital
2016-2025
Sultan Qaboos University
2012-2024
University of Tartu
2024
Competence Centre on Health Technologies (Estonia)
2024
Muscat College
2007-2023
Ceinge Biotecnologie Avanzate (Italy)
2021
Marymount University
2013
Institute of Child Health
2012
Planetary Science Institute
2012
Laboratoire Dr Renaud
2006
The aim of our study was to assess the cytokine profile sickle cell disease (SCD) patients in steady state and vaso-occlusive crisis (VOC). VOC has a complex nature, involving interactions between red blood cells (RBC), endothelium, leucocytes. Endothelial damage due recurrent adhesion RBCs may disrupt endothelial function, leading altered release. It is therefore pertinent SCD prior exploring its contribution manifestations, since it believed that an balance proinflammatory...
To evaluate the incidence of hemoglobinopathies in Omani subjects and to forecast its future burden on health resources, we initiated a prospective neonatal screening program two major cities Sultanate Oman. Consecutive cord blood samples from total 7,837 neonates were analyzed for complete counts hemoglobin (Hb) profile by high performance liquid chromatography (HPLC). No case with Hb H (β4) was detected. We observed that overall α-thalassemia (α-thal) 48.5% [based presence Bart's (γ4)]...
The goal of this article is to study the association known markers thrombophilia with venous thrombosis in young patients (< 45 years) from Western part India. A prospective 432 (252 males and 180 females, age 1-45 was conducted between 1994 2000 (6 years). diagnosis confirmed all by ultrasound Doppler or a computed tomograph (CT) scan brain without contrast depending on case. Detailed clinical examination, family history taken establish recurrent familial occurrence thrombosis. studied...
This subgroup analysis evaluated the effect of once-daily oral deferasirox on labile plasma iron (LPI) levels in patients from prospective, 1-yr, multicentre ESCALATOR study. Mean baseline liver concentration and median serum ferritin were 28.6 +/- 10.3 mg Fe/g dry weight 6334 ng/mL respectively, indicating high burden despite prior chelation therapy. Baseline LPI (0.98 0.82 micromol/L) decreased significantly to 0.12 0.16 micromol/L, 2 h after first dose (P = 0.0006). Reductions pre-...
Noninvasive measurement of tissue iron levels can be assessed using T2* magnetic resonance imaging (MRI) to identify and monitor patients with overload. This study monitored cardiac siderosis MRI in a cohort 19 heavily iron-overloaded β-thalassemia major receiving chelation therapy deferasirox over an 18-month period. Overall, significantly improved mean ± standard deviation from baseline 17.2 10.8 21.5 12.8 ms (+25.0%; P = 0.02). A concomitant reduction median serum ferritin 5,497 4,235...
ObjectivesThe study aimed to assess COVID-19 impact on the morbidity and mortality of vasooclusive crisis (VOC) in sickle cell anaemia (SCA) patients.MethodsA prospective cohort 100 SCA patients; 50 with (COVID group) without (non-COVID group). All patients signed written informed consent.ResultsThe COVID group had a significantly higher VOC episode median per year; 3 (IQR,1-6) vs 2 (IQR,2-12) (P < 0.05). The need for hospitalisation was similar both groups. non-COVID more history...
Abstract Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and leading cause for hospital admissions death. We aimed to study the spectrum clinical laboratory features ACS assess predisposing factors predictors severity. A retrospective case-control cohort was studied by retrieving patient information from electronic medical records after ethical approval. One hundred adolescents adults with SCA were identified through discharge summaries, along 20 additional...
Abstract Sickle cell disease (SCD) is a major public health burden worldwide with increasing morbidity and mortality. The study evaluates the risk factors associated mortality in SCD patients, between years 2006 2020 at three hospitals Oman. analysis includes clinical manifestations, haematological, biochemical, radiological parameters, use of antibiotics, blood exchange transfusions. Our cohort included 123 patients (82 males, 41 females), median age 27 (Interquartile Range 21–35 years)....
X-linked sideroblastic anemia (XLSA) (MIM 300752) is the most common genetic form of anemia, a heterogeneous group disorders characterized by iron deposits in mitochondria erythroid precursors. It due to mutations erythroid-specific enzyme ALAS2 , first heme biosynthetic pathway. Herein, we report novel 11-bp deletion exon 11 leading frameshift C-terminal region gene with non-functional longer polypeptide 614 amino acids loss-of-function mutation manifested as an phenotype. The proband was...
Abstract Mutations in the anion exchanger 1 ( AE1 ) gene encoding erythroid and kidney (chloride–bicarbonate) may result familial distal renal tubular acidosis (dRTA) association with membrane defect hemolytic anemia. Seven children presenting hyperchloremic normal gap metabolic acidosis, failure to thrive, compensated anemia were studied. Analysis of red cell /Band 3 surface expression by Eosin 5′‐maleimide (E5M) was performed patients their family members using flow cytometry. Genetic...
Abstract Background: Sickle cell disease (SCD) is characterized by intermittent episodes of vascular occlusion and end‐organ damage. Neurologic symptoms are frequent auditory involvement not unexpected. Aim: To study the prevalence pattern hearing loss in Omani patients with SCD. Methods: We conducted a prospective case control on SCD attending outpatient department. Age sex matched normal volunteer blood donor controls were recruited after an informed consent Medical Ethics Committee...
Chronic granulomatous disease (CGD), a rare inherited disorder of the innate immune system, results from mutations in any one five genes encoding subunits nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) oxidase enzyme, and is characterized by recurrent life-threatening bacterial fungal infections. Molecular analysis 14 Omani CGD patients 10 families, diagnosed to have on clinical (recurrent infections) biochemical grounds (positive for both nitroblue tetrazolium (NBT) test...
Blood transfusion is an integral part of the supportive care for patients with sickle cell disease (SCD) and thalassaemia. The hazard red alloimmunization, however, one main complications this therapy.The aim study was to evaluate prevalence alloimmunization in Omani anaemia thalassemia.This included 262 whose historical records were available. One hundred twenty-nine thalassaemia who attending day unit regular transfusions, 133 SCD admitted at our hospital study. Diamed® gel system used...