A5064456725- Liquid Crystal Research Advancements
- Pickering emulsions and particle stabilization
- Gold and Silver Nanoparticles Synthesis and Applications
- Surfactants and Colloidal Systems
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Veterinary Oncology Research
- Analytical Chemistry and Sensors
- Nonlinear Dynamics and Pattern Formation
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Photonic Crystals and Applications
- Advanced Materials and Mechanics
- Photochromic and Fluorescence Chemistry
- Quantum Dots Synthesis And Properties
- Micro and Nano Robotics
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticles: synthesis and applications
- Reproductive Biology and Fertility
- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Nanocluster Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Nonlinear Optical Materials Studies
University of Warsaw
2015-2024
Wrocław University of Science and Technology
2019
Silesian University of Technology
2016
// Ewelina Zielinska 1 , Agata Zauszkiewicz-Pawlak 2 Michal Wojcik 3 and Iwona Inkielewicz-Stepniak Department of Medical Chemistry, University Gdansk, Debinki 1, 80-211 Poland Histology, Faculty Warsaw, Pasteura 02-093 Correspondence to: Inkielewicz-Stepniak, email: iinkiel@gumed.edu.pl Keywords: pancreas ductal adenocarcinoma cells; silver nanoparticles; autophagy; necroptosis; mitotic catastrophe Received: July 20, 2017 Accepted: October 13, Published: November ABSTRACT Pancreatic...
Spontaneous formation of smectic and columnar structures was observed when spherical gold nanoparticles were functionalized with mesogenic thiols (see layered structure X-ray pattern a sample in phase). The particle ordering is stimulated by softening the interparticle potential flexibility for deformation grafting layer.
The availability of helical assemblies plasmonic nanoparticles with precisely controlled and tunable structures can play a key role in the future development chiral plasmonics metamaterials. Here, strategy to efficiently yield based on cooperative interactions liquid crystals gold thin films is developed. These nanocomposites exhibit exceptional long-range hierarchical order across length scales, which results from growth mechanism nanoparticle-coated twisted nanoribbons their ability form...
The ability of gold nanoparticles grafted with soft, adaptive organic layers made two types thiol molecules, n-alkyl and mesogenic ones, to form spontaneously long-range positionally ordered structures is shown. It was found that molecular structure thiols as well the can affect type phase. A number structures, smectic, undulated smectic columnar phases, were obtained thanks self-segregation simple ligands at nanoparticle surface.
Background Feline injection-site sarcomas are malignant skin tumors of mesenchymal origin, the treatment which is a challenge for veterinary practitioners. Methods include radical surgery, radiotherapy and chemotherapy. The most commonly used cytostatic drugs cyclophosphamide, doxorubicin vincristine. However, use cytostatics as adjunctive limited due to their adverse side-effects, low biodistribution after intravenous administration multidrug resistance. Colloid gold nanoparticles promising...
Composite structures exhibiting a periodic arrangement of building blocks can be found in natural systems at different length scales. Recreating such artificial composites using the principles self-assembly has been great challenge, especially for 1D microscale systems. Here, we present purposely designed composite material consisting gold nanoparticles and nematic liquid crystal matrix that ability to self-create structure form one-dimensional photonic lattice through phase separation...
We studied the effects of silver nanoparticles (AgNPs) on human blood platelet function. hypothesized that AgNPs, a known antimicrobial agent, can be used as blood-compatible, "ideal material'' in medical devices or drug delivery system. Therefore, aim current study was to investigate if functionalized AgNPs affect function and platelets well endothelial cell viability vitro.AgNPs, with reduced glutathione (GSH), polyethylene glycol (PEG) lipoic acid (LA) were synthesized. Quartz crystal...
We describe the fabrication of dual-responsive (thermo/light) chiral plasmonic films. The idea is based on using photoswitchable achiral liquid crystal (LCs) forming nanotubes for templating helical assemblies Au NPs. Circular dichroism spectroscopy (CD) confirms chiroptical properties coming from arrangement organic and inorganic components, with up to 0.2 dissymmetry factor (g-factor). Upon exposure UV light, molecules isomerize, resulting in controlled melting and/or nanohelices. process...
Gold nanoparticles grafted with promesogenic ligands show temperature induced liquid crystalline polymorphism unique phase sequence: from smectic to columnar structure. The transition is entropy driven; increasing attached nanoparticle surface require more space fluctuate. In result layer becomes deformed ('peristaltic mode') and voids between metal particles filled organic molecules form a hexagonal
Blue phase liquid crystals (BPLCs) are chiral mesophases with 3D order, which makes them a promising template for doping nanoparticles (NPs), yielding tunable nanomaterials attractive microlasers and numerous microsensor applications. However, NPs to BPLCs causes BP lattice extension, translates elongation of operating wavelengths light reflection. Here, it is demonstrated that small (2.4 nm diameter) achiral gold (Au) decorated designed LC-like ligands can enhance the twist (i.e., reduce...
For the first time, application of a membrane composed gold nanoparticles decorated with complexing ligand for potentiometric sensing is shown. Gold drop cast from solution form porous structure on substrate electrode surface. Sample cations can penetrate layer and interact acting as charged ionophore, resulting in Nernstian responses. Anchoring surface abolishes necessity ionophore application. Moreover, it opens possibility preparation sensors using chelators significantly different...
Due to the high toxicity of currently used chemotherapeutics, novel methods cancer treatment are needed.Gold nanoparticles (AuNPs) seem be an interesting alternative due penetration through biological membranes and systemic barriers.AuNPs as carriers chemotherapeutics allow for reduced concentrations whilst maintaining expected effect, thus reducing costs therapy adverse effects.We synthesized AuNPs stabilized with glutathione (GSH) conjugated doxorubicin (DOX), gemcitabine (GEM) or...
In this Letter, we show how advanced hierarchical structures of topological defects in the so-called smectic oily streaks can be used to sequentially transfer their geometrical features gold nanospheres. We use two kinds defects, 1D dislocations and 2D ribbon-like defects. The large trapping efficiency dislocation cores not only surpasses that elastically distorted zones around but also one defect. This enables formation a number aligned NP chains within quasi-fully filled without any...
Purpose: To study and compare the antibacterial properties potential cytotoxic effects of commercially available uncoated silver nanoparticles (AgNPs) with lipoic acid coated (AgNPsLA) developed by our group. The antibacterial, cytotoxic, hemolytic those NPs were assessed main objective investigating if AgNPsLA could maintain their while improving biosafety profile over AgNPs within blood vessel's microenvironment. Methods: Comercially 2.6 nm 2.5 synthesized characterized as previously...
For rod-like molecules with two chiral centers de-racemization results in formation of a tetragonal mesophase instead cubic one.
The properties of liquid-crystalline (LC) hybrid systems made inorganic nanoparticles grafted with photosensitive azo compounds are presented. For materials a large density ligands at the surface, LC structure can be reversibly melted by UV light, and return to state does not require absorption visible light. lower ligands, light causes shortening distance between metal sublayers in lamellar phase. Interestingly, derivatives attached nanoparticle surface show very different kinetics...
Feline injection-site sarcomas are malignant skin tumours with a high local recurrence rate, ranging from 14% to 28%. The treatment of feline includes radical surgery, radiotherapy and/or chemotherapy. In our previous study it has been demonstrated that doxorubicin conjugated glutathione-stabilized gold nanoparticles (Au-GSH-Dox) higher cytotoxic effects than free for fibrosarcoma cell lines glycoprotein P activity (FFS1, FFS3). aim the present was assess effectiveness intratumoural...
3D nanoparticle-based materials with reconfigurable structure have gained vast attention due to the unique possibility of tailoring nanoparticle-related quantum confinement effects. These properties make active nanoparticle assemblies promising candidates for future optoelectronic and metamaterial technologies; however, integration these into real-world applications is still challenging. In this context, use stimuli responsive liquid-crystals (LCs) offers a fascinating industrially feasible...
Osteosarcoma (OSA) is the most common malignant bone neoplasia in humans and dogs. In dogs, treatment consists of surgery combination with chemotherapy (mostly carboplatin and/or doxorubicin (Dox)). Chemotherapy often rendered ineffective by multidrug resistance. Previous studies have revealed that Dox conjugated 4 nm glutathione-stabilized gold nanoparticles (Au-GSH-Dox) enhanced anti-tumor activity cytotoxicity Dox-resistant feline fibrosarcoma cell lines exhibiting high P-glycoprotein...
Abstract Gold nanoparticles surface modified with dithizone were applied as dedicated transducer in ion‐selective electrodes. The presence of a gold nanoparticle layer beneath the membrane enables tailoring copper ion fluxes all‐solid‐state selective potentiometric Thus, depending on pretreatment layer, different responses can be obtained: from typical for systems lowered activity primary ions at back side (with super‐Nernstian slope region), through low detection limit to classical ones.
Abstract Embedding nanoparticles in a responsive polymer matrix is formidable way to fabricate hybrid materials with predesigned properties and prospective applications actuators, mechanically tunable optical elements, electroclinic films. However, achieving chemical compatibility between organic matter not trivial often results disordered structures. Herein, it shown that using as exclusive cross‐linkers the preparation of liquid‐crystalline polymers can yield long‐range‐ordered elastomers...
Feline injection site sarcomas (FISS) are malignant skin tumors with high recurrence rates despite the primary treatment of radical surgical resections. Adjunctive radiotherapy or chemotherapy doxorubicin is mostly ineffective. Cellular and molecular causes multidrug resistance, specific physio-chemical properties solid impairing drug transport, tumor microenvironment have been indicated for causing standard failure. Gold nanoparticles promising imaging tools, nanotherapeutics, delivery...