A5001511212- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Luminescence and Fluorescent Materials
- Nuclear Structure and Function
- Ferroptosis and cancer prognosis
- Photodynamic Therapy Research Studies
- Inflammasome and immune disorders
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- RNA Research and Splicing
- Redox biology and oxidative stress
- Immune Response and Inflammation
- Diabetes and associated disorders
- Molecular Junctions and Nanostructures
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- interferon and immune responses
- Autophagy in Disease and Therapy
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Genomics and Chromatin Dynamics
New York University
2021-2025
NYU Langone Health
2024
Indian Institute of Technology Jodhpur
2017-2022
Gliomas are the most prevalent primary brain tumors with immense clinical heterogeneity, poor prognosis and survival. The nucleotide-binding domain, leucine-rich repeat containing receptors (NLRs) absent-in-melanoma 2 (AIM2) innate immune crucial for initiation progression of several cancers. There is a dearth reports linking NLRs AIM2 to glioma pathology. expressed by cells immunity, including monocytes, macrophages, dendritic cells, endothelial neutrophils, as well adaptive system....
BODIPY (Boron-Dipyrromethene) dyes have emerged as versatile fluorescent probes in cellular imaging and therapeutic applications, owing to their unique chemical properties, including high fluorescence quantum yield, strong extinction coefficients, remarkable photostability. This review synthesizes the recent advancements dyes, focusing on deployment biological therapy. The exceptional ability of selectively stain structures enables precise visualization lipids, proteins, nucleic acids within...
BODIPY (Boron-Dipyrromethene) dyes have emerged as versatile fluorescent probes in cellular imaging and therapeutic applications owing to their unique chemical properties, including high fluorescence quantum yield, strong extinction coefficients, remarkable photostability. This review synthesizes the recent advancements dyes, focusing on deployment biological therapy. The exceptional ability of selectively stain structures enables precise visualization lipids, proteins, nucleic acids within...
Dopamine (DA) plays many roles in the brain, especially movement, motivation, and reinforcement of behavior; however, its role regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps primary, adult, human microglia BV2 cell line. These are formed independent reactive oxygen species, actin polymerization, death. functional capture fluorescein (FITC)-tagged Escherichia coli even when species production or polymerization inhibited. We microglial...
Abstract The cell interior is highly crowded and far from thermodynamic equilibrium. This environment can dramatically impact molecular motion assembly, therefore influence subcellular organization biochemical reaction rates. These effects depend strongly on length-scale, with the least information available at important mesoscale (10-100 nanometers), which corresponds to size of crucial regulatory molecules such as RNA polymerase II. It has been challenging study physical properties...
Abstract Hypoxia is a pathological condition known to occur in several diseases including stroke and certain cancers. The development testing of portable hypoxia chamber remains challenge. simulating devices typically consist sealed that placed inside the existing laboratory incubator at 37°C. Existing for hypoxic environments are cost space inefficient. This study describes portable, cost‐efficient with small footprint low running cost. Performance was validated through cell microbial...
Microglia are resident innate immune cells of the central nervous system (CNS). play a critical role during development, in maintaining homeostasis, and infection or injury. Several independent research groups have highlighted that microglia autoimmune diseases, autoinflammatory syndromes cancers. The activation some neurological diseases may directly participate pathogenic processes. Primary powerful tool to understand responses brain, cell-cell interactions dysregulated phenotypes disease....
Extracellular traps (ETs) are composed of decondensed chromatin and embedded with various antimicrobial proteins like myeloperoxidase histones. Recently, we reported that dopamine (DA) induces ETs in BV2 microglia cell line primary adult human a manner independent death, reactive oxygen species, actin polymerization. This protocol details how to characterize DA-induced microglia. The protocols for characterization may also be used other adherent lines. For complete on the use execution this...
Dopamine plays many roles in the brain, especially in; movement, motivation, and reinforcement of behavior, however, its role regulating innate immunity is not clear. Here we show for first time that dopamine can induce DNA based extracellular traps primary, adult, human microglia BV2 cell line. These are formed independent reactive oxygen species, actin polymerization death. functional capture FITC tagged Escherichia coli even when species production or inhibited. We present Glioblastoma...
Microglia are resident innate immune cells of the central nervous system (CNS). play a critical role during development, in maintaining homeostasis, and infection or injury. Several independent research groups have highlighted that microglia autoimmune diseases, autoinflammatory syndromes cancers. The activation some neurological diseases may directly participate pathogenic processes. Primary powerful tool to understand responses brain, cell-cell interactions dysregulated phenotypes disease....
Abstract Gliomas are the most prevalent primary brain tumors with immense clinical heterogeneity, poor prognosis and survival. arise from glial cells heavily infiltrated innate immune cells. In India high-grade gliomas or Glioblastomas (GBM) account for 59.5% of CNS tumours. A key challenge management GBM is its highly heterogeneous nature-between patients within a single tumour-making current therapies ineffective. The nucleotide-binding domain, leucine-rich repeat containing receptors...
Abstract Dopamine (DA) is central to neurological functions like motivation, movement and reward (Klein et al. 2019). While its role in diseases Parkinson’s, Alzheimer’s schizophrenia are well studied, regulating immune have just started unfold. DA receptors present on almost all cells they regulate innate adaptive immunity (Matt Gaskill 2020). We investigated the of formation extracellular traps (ETs) microglia. report that can induce ETs BV2 microglia cell line primary adult human composed...