A5062847422- Neuroscience and Neuropharmacology Research
- Magnolia and Illicium research
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Neurotoxicity Research
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Treatment of Major Depression
- Oxidative Organic Chemistry Reactions
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Ion channel regulation and function
- Nuclear Receptors and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Nitric Oxide and Endothelin Effects
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Neuroscience and Neural Engineering
- Zebrafish Biomedical Research Applications
- Stress Responses and Cortisol
- Animal testing and alternatives
- Receptor Mechanisms and Signaling
- Prenatal Substance Exposure Effects
- Molecular Sensors and Ion Detection
National Chengchi University
2015-2024
China Medical University Hospital
2020-2024
China Medical University
2020-2024
Tzu Chi University
2003-2020
Taipei Institute of Pathology
2020
University of Missouri
2013
National Dong Hwa University
2012
Institute of Pharmacology
2007
Zero to Three
2007
Kyoto University
2007
The bark of magnolia has been used in Oriental medicine to treat a variety remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers polyphenolic compounds from the Magnolia officinalis, have identified as major active components exhibiting anti-oxidative, anti-inflammatory, neuroprotective effects. In this study, we investigate ability these suppress oxidative stress neurons stimulated by ionotropic glutamate receptor agonist N-methyl-D-aspartate (NMDA)...
Abstract: Plasma membranes of animal cells are generally impermeable to macromolecules. Protein transduction mediated by protein domains (PTDs) covalently cross‐linked cargoes for cellular internalization has previously been demonstrated. Peptides with PTDs could be an effective way deliver proteins into living or tissues in vitro . In this report, we demonstrate that arginine‐rich intracellular delivery (AID) peptides able facilitate the and penetrate skin rapidly. This transdermal is...
Abstract The antinociceptive effects of honokiol and magnolol, two major bioactive constituents the bark Magnolia officinalis , were investigated on animal paw licking responses thermal hyperalgesia induced by glutamate receptor agonists including glutamate, N-methyl-D-aspartate (NMDA), metabotropic 5 (mGluR5) activator (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), as well inflammatory mediators such substance P prostaglandin E 2 (PGE ) in mice. actions magnolol glutamate-induced c-Fos...
Tanshinone IIA is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that used to treat cardiovascular and inflammatory diseases. Recently, tanshinone was demonstrated induce cell death apoptosis variety of tumors. However, effect on human colon cancer cells not clearly understood yet. In this study, antigrowth apoptosis-eliciting effects IIA, as well its cellular mechanisms actions, were investigated Colo-205 cells....
Abstract Background In order to understand the interaction between metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, influence of mGluR5 positive modulators in inhibition NMDA receptors by noncompetitive antagonist ketamine, competitive D-APV selective NR2B inhibitor ifenprodil was investigated. Methods This study used multi-electrode dish (MED) system observe field potentials hippocampal slices mice. Results Data showed that agonist...
In this study, we examine whether an anti‐inflammatory thiourea derivative, compound #326, actions on ion channels. The effects of #326 Ca 2+ ‐activated K + channels were evaluated by patch‐clamp recordings obtained in cell‐attached, inside‐out or whole‐cell configuration. pituitary GH 3 cells, increased the amplitude currents ( I K(Ca) ) with EC 50 value 11.6 μM, which was reversed verruculogen, but not tolbutamide TRAM‐34. Under configuration, a bath application raised probability...
Magnolol and honokiol are the two major phenolic constituents of plant medicine "Houpo" (Magnolia obovata), which is used in treatment chest tightness asthma. The aim this study was to investigate influence magnolol on smooth muscle tone porcine trachea. (0.1 - 100 μM) inhibited carbachol- high K+-induced contractions a concentration-dependent fashion, but did not affect basal tension. After washout these pretreatments, K+-evoked were still abolished, suggesting that inhibition irreversible....
The repeated administration of methamphetamine (MA) to animals in a single-day 'binge' dosing regimen produces damage dopamine and serotonin terminals psychosis-like behaviours similar those observed MA abusers. present study aimed examine the effects binge exposure on 5-HT 2A receptors, subtype receptors putatively involved psychosis. ICR male mice were treated with (4 × 5 mg/kg) or saline at 2 h intervals. Recognition memory social sequentially evaluated by novel location recognition test,...
Abstract Hair cells are highly sensitive to environmental insults and other therapeutic drugs. The adverse effects of drugs such as aminoglycosides can cause hair cell death lead hearing loss imbalance. objective the present study was evaluate protective activity L‐ascorbic acid, N ‐acetylcysteine (NAC) apocynin on neomycin‐induced damage in zebrafish ( Danio rerio ) larvae at 5 days post fertilization (dpf). Results showed that within neuromasts lateral lines after neomycin exposure...