A5013951741- Pancreatic function and diabetes
- Nerve injury and regeneration
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Spinal Cord Injury Research
- Nutrition, Genetics, and Disease
- Biosimilars and Bioanalytical Methods
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Pluripotent Stem Cells Research
- Protein Kinase Regulation and GTPase Signaling
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Developmental Biology and Gene Regulation
- Liver physiology and pathology
- Neuropeptides and Animal Physiology
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Bowel Disease
- Nerve Injury and Rehabilitation
- Cancer, Stress, Anesthesia, and Immune Response
University of California, San Diego
2021-2024
Vellore Institute of Technology University
1969-2019
Molecular Theranostics (United States)
2018-2019
Single-cell studies have revealed that intestinal macrophages maintain gut homeostasis through the balanced actions of reactive (inflammatory "accelerators") and tolerant (non-inflammatory "brakes") subpopulations. How these populations function in inflammatory bowel diseases (IBD), including Crohns disease (CD) ulcerative colitis (UC), remains unresolved. Using multi-omics data computational tools, here we define colon-specific macrophage states reveal critical role non-inflammatory...
Although neural stem cells (NSCs) have potential applications in treating neurological disorders, much still needs to be understood about the differentiation biology for their successful clinical translation. In this study, we aimed at deriving NSCs from human umbilical cord blood-derived mesenchymal (hUCB-MSCs) and explored role of Notch signaling process. The hUCB-MSCs were characterized as per guidelines International Society Cellular Therapy. successfully generated by using epidermal...
Despite advances in artificial intelligence (AI), target-based drug development remains costly, complex, and imprecise. We introduce F.O.R.W.A.R.D [Framework for Outcome-based Research Drug Development], a network-based target prioritization platform, demonstrate its utility the challenging landscape of Inflammatory Bowel Diseases (IBD), chronic, multifactorial condition. uses real-world clinical outcomes, machine-learning classifier trained on transcriptomic data from seven prospective...
Human mesenchymal stem cells (hMSCs) although being potent in repairing injured or ischemic tissues, their success regarding tissue-regenerative approaches are hindered by the paucity viability. The elevated levels of reactive oxygen species (ROS) damaged sites provoke pernicious effects donor MSC survival. In present study, effect delta-opioid receptor (DOR) activation on human umbilical cord-blood borne fibroblasts (hUCB-BFs) survival under oxidative stress (H2O2) was evaluated. Oxidative...
Background: The Fat mass and obesity-associated gene (FTO) its involvement in weight gain obesity is well-known. However, no reports have been published on the Indian population regarding relationship between single nucleotide polymorphisms (SNPs) intronic region obesity. aim of this pilot study was to evaluate frequency association SNPs intron-1 FTO obese overweight adults. Methods: This group consisted 80 adults, aged 23.5 ± 8.9 yr, with a mean BMI 28.8 6.2 kg/m2. Genomic DNA isolated,...
ABSTRACT/SUMMARY Sensing of pathogens by Nucleotide oligomerization domain (NOD)-like 2 receptor (NOD2) induces a protective inflammatory response that coordinates bacterial clearance. Polymorphisms in NOD2 impair clearance, leading to chronic gut inflammation Crohn’s disease (CD) via mechanisms remain incompletely understood. We identify GIV/Girdin (CCDC88A) as NOD2-interactor shapes sensing-and-signaling macrophages. Myeloid-specific GIV depletion exacerbated and protracted infectious...